Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Sánchez-Vioque R et al. Interaction of chickpea (Cicer arietinum L.) legumin with oxidized linoleic acid. 1999 J. Agric. Food Chem. pmid:10552371
Domingo N et al. Effects of dexamethasone and linoleic acid on hepatic secretion of biliary lipids and anionic polypeptide factor: In vivo and in vitro studies. 1999 Nov-Dec Digestion pmid:10545720
Kulkarni AP and Sajan M Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. 1999 Arch. Biochem. Biophys. pmid:10545208
Murphy J et al. Fat malabsorption in cystic fibrosis patients. 1999 Am. J. Clin. Nutr. pmid:10539762
Rose DP and Connolly JM Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice. 1999 Int. J. Oncol. pmid:10536186
Dhiman TR et al. Conjugated linoleic acid content of milk from cows fed different diets. 1999 J. Dairy Sci. pmid:10531600
Howard FA and Henderson C Hydrogenation of polyunsaturated fatty acids by human colonic bacteria. 1999 Lett. Appl. Microbiol. pmid:10530040
Filley SJ et al. Prostaglandin f(2alpha) concentrations, fatty acid profiles, and fertility in lipid-infused postpartum beef heifers. 1999 Biol. Reprod. pmid:10529280
Dauchy RT et al. Dim light during darkness stimulates tumor progression by enhancing tumor fatty acid uptake and metabolism. 1999 Cancer Lett. pmid:10529012
Minich DM et al. Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. 1999 Biochim. Biophys. Acta pmid:10526224
Arutselvan N et al. Antioxidative activity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. 1999 Arzneimittelforschung pmid:10514898
Xu M and Dashwood RH Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. 1999 Cancer Lett. pmid:10503900
Masella R et al. Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. 1999 Redox Rep. pmid:10496414
Tamatani T et al. Neoplastic conversion of human urothelial cells in vitro by overexpression of H2O2-generating peroxisomal fatty acyl CoA oxidase. 1999 Int. J. Oncol. pmid:10493957
Rickert KW and Klinman JP Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. 1999 Biochemistry pmid:10493789
Blask DE et al. Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. 1999 Cancer Res. pmid:10493527
Sauer LA et al. 13-Hydroxyoctadecadienoic acid is the mitogenic signal for linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo. 1999 Cancer Res. pmid:10493526
Precht D and Molkentin J C18:1, C18:2 and C18:3 trans and cis fatty acid isomers including conjugated cis delta 9, trans delta 11 linoleic acid (CLA) as well as total fat composition of German human milk lipids. 1999 Nahrung pmid:10481820
Kankaanpää P et al. Dietary fatty acids and allergy. 1999 Ann. Med. pmid:10480759
Lin MY and Yen CL Reactive oxygen species and lipid peroxidation product-scavenging ability of yogurt organisms. 1999 J. Dairy Sci. pmid:10480088