Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Oh JM et al. | Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells. | 2012 | Toxicol In Vitro | pmid:22683933 |
| Matsubara T et al. | TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. | 2012 | J. Lipid Res. | pmid:23034213 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| Harvey KA et al. | Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. | 2012 | Lipids | pmid:22684911 |
| Montaño M et al. | New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. | 2012 | Toxicol. Sci. | pmid:22859314 |
| Ebba S et al. | The examination of fatty acid taste with edible strips. | 2012 | Physiol. Behav. | pmid:22521910 |
| Ruparel S et al. | Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. | 2012 | Pain | pmid:22633978 |
| Dramane G et al. | STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. | 2012 | J. Clin. Invest. | pmid:22546859 |
| Naqvi AZ et al. | Dietary fatty acids and peripheral artery disease in adults. | 2012 | Atherosclerosis | pmid:22552117 |
| Joshi S et al. | Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | 2012 | Org. Biomol. Chem. | pmid:22986997 |
| Perdriau S et al. | Selective conversion of polyenes to monoenes by RuCl(3) -catalyzed transfer hydrogenation: the case of cashew nutshell liquid. | 2012 | ChemSusChem | pmid:23060315 |
| O'Donnell-Megaro AM et al. | Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. | 2012 | J. Dairy Sci. | pmid:23063161 |
| Coimbra MC and Jorge N | Fatty acids and bioactive compounds of the pulps and kernels of Brazilian palm species, guariroba (Syagrus oleraces), jerivá (Syagrus romanzoffiana) and macaúba (Acrocomia aculeata). | 2012 | J. Sci. Food Agric. | pmid:21922463 |
| Shah BP et al. | TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:21998136 |
| Marincola FC et al. | A metabolomic study of preterm human and formula milk by high resolution NMR and GC/MS analysis: preliminary results. | 2012 | J. Matern. Fetal. Neonatal. Med. | pmid:23025771 |
| Kanter JE et al. | Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. | 2012 | Biochim. Biophys. Acta | pmid:22020260 |
| Poompachee K and Chudapongse N | Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. | 2012 | Med Princ Pract | pmid:22024634 |
| de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
| Rasic-Milutinovic Z et al. | Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. | 2012 | Arch. Med. Res. | pmid:22222492 |
| Stachowska E et al. | Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. | 2012 | Int J Food Sci Nutr | pmid:21721848 |
| Gursoy O et al. | The effect of using different probiotic cultures on conjugated linoleic acid (CLA) concentration and fatty acid composition of white pickle cheese. | 2012 | Int J Food Sci Nutr | pmid:22166042 |
| Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
| Levitan EB et al. | α-Linolenic acid, linoleic acid and heart failure in women. | 2012 | Br. J. Nutr. | pmid:22172525 |
| Taârit MB et al. | Physiological changes, phenolic content and antioxidant activity of Salvia officinalis L. grown under saline conditions. | 2012 | J. Sci. Food Agric. | pmid:22173568 |
| Byun HJ et al. | Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. | 2012 | J. Dermatol. Sci. | pmid:22209282 |
| Cheguru P et al. | Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. | 2012 | Pflugers Arch. | pmid:22218833 |
| Ramos Morales E et al. | Ricinoleic acid inhibits methanogenesis and fatty acid biohydrogenation in ruminal digesta from sheep and in bacterial cultures. | 2012 | J. Anim. Sci. | pmid:22829608 |
| Manzoor M et al. | Variation in minerals, phenolics and antioxidant activity of peel and pulp of different varieties of peach (Prunus persica L.) fruit from Pakistan. | 2012 | Molecules | pmid:22728349 |
| Ogawa N et al. | Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. | 2012 | Metab. Clin. Exp. | pmid:22445513 |
| Beevi SS et al. | Polyphenolics profile and antioxidant properties of Raphanus sativus L. | 2012 | Nat. Prod. Res. | pmid:21714734 |
| Shen J et al. | Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. | 2012 | Lipids Health Dis | pmid:22781401 |
| Zengin G et al. | Composition of essential oil and antioxidant capacity of Centaurea drabifolia Sm. subsp. detonsa (Bornm.) Wagenitz, endemic to Turkey. | 2012 | Nat. Prod. Res. | pmid:21714737 |
| Amoo SO et al. | Antioxidant and acetylcholinesterase-inhibitory properties of long-term stored medicinal plants. | 2012 | BMC Complement Altern Med | pmid:22769046 |
| Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
| Zein CO et al. | Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. | 2012 | Hepatology | pmid:22505276 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
| Zened A et al. | In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. | 2012 | Animal | pmid:22436225 |
| Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
| Jarvis MF | Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. | 2012 | Pain | pmid:22681878 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Wu J et al. | Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. | 2012 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:22687573 |
| Reynolds CM et al. | Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. | 2012 | Mol Nutr Food Res | pmid:22700321 |
| Ladeira MM et al. | Lipids in the diet and the fatty acid profile in beef: a review and recent patents on the topic. | 2012 | Recent Pat Food Nutr Agric | pmid:22702746 |
| de Freitas JM et al. | Influence of cellular fatty acid composition on the response of Saccharomyces cerevisiae to hydrostatic pressure stress. | 2012 | FEMS Yeast Res. | pmid:22846157 |
| Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
| Yu T et al. | Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. | 2012 | Pflugers Arch. | pmid:22644615 |
| de Sousa Ferreira Soares G et al. | Spectroscopic and thermooxidative analysis of organic okra oil and seeds from Abelmoschus esculentus. | 2012 | ScientificWorldJournal | pmid:22645459 |
| Xie J et al. | Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. | 2012 | Nat. Prod. Res. | pmid:21707231 |
| Wakabayashi K et al. | Species differences in toxicokinetic parameters of glycidol after a single dose of glycidol or glycidol linoleate in rats and monkeys. | 2012 | J Toxicol Sci | pmid:22863850 |