Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Acute Coronary Syndrome D054058 11 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Restenosis D023903 10 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Circoviridae Infections D018173 2 associated lipids
Glucose Intolerance D018149 13 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Hyperpigmentation D017495 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Helicobacter Infections D016481 21 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Lasa A et al. The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. 2011 Sep-Oct Nutr Hosp pmid:22072344
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Ramandi NF et al. Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. 2011 Nov-Dec J. Food Sci. pmid:22416687
Olszewska MA Variation in the phenolic content and in vitro antioxidant activity of Sorbus aucuparia leaf extracts during vegetation. 2011 Nov-Dec Acta Pol Pharm pmid:22125960
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Kezutyte T et al. Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo. 2011 Nov-Dec Acta Pol Pharm pmid:22125963
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Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Monfregola L et al. Physical and water sorption properties of chemically modified pectin with an environmentally friendly process. 2011 Biomacromolecules pmid:21553919
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
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Palmieri-Thiers C et al. Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. 2011 Arch. Biochem. Biophys. pmid:21345329
Royan M et al. Effects of conjugated linoleic acid, fish oil and soybean oil on PPARs (α & γ) mRNA expression in broiler chickens and their relation to body fat deposits. 2011 Int J Mol Sci pmid:22272093
Prasad A and Pospíšil P Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. 2011 PLoS ONE pmid:21799835
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Vedtofte MS et al. Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. 2011 Am. J. Clin. Nutr. pmid:21865326
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Banta JP et al. Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. 2011 J. Anim. Sci. pmid:21788431
Končić MZ et al. Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. 2011 Molecules pmid:21788931
Ramsden CE et al. All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. 2011 World Rev Nutr Diet pmid:21865817
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Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Simon E et al. Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression. 2011 Exp. Eye Res. pmid:21821023
Arawwawala M et al. In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. 2011 Acta. Biol. Hung. pmid:21840826
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Ogawa E et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. 2011 J. Invest. Dermatol. pmid:21068754
Arciniega JC et al. Effects of free fatty acids on meibomian lipid films. 2011 Exp. Eye Res. pmid:21718696
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Göçer H and Gülçin I Caffeic acid phenethyl ester (CAPE): correlation of structure and antioxidant properties. 2011 Int J Food Sci Nutr pmid:21631390
Lautenslager GT et al. Effects of nonenzymatic glycation and fatty acids on functional properties of human albumin. 2011 Metab. Clin. Exp. pmid:21632076
Aewsiri T et al. Surface activity and molecular characteristics of cuttlefish skin gelatin modified by oxidized linoleic acid. 2011 Int. J. Biol. Macromol. pmid:21334373
You Q et al. Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. 2011 Bioprocess Biosyst Eng pmid:21340675
Serratosa MP et al. Changes in hydrophilic and lipophilic antioxidant activity in relation to their phenolic composition during the chamber drying of red grapes at a controlled temperature. 2011 J. Agric. Food Chem. pmid:21319807
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Perona JS et al. Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. 2011 Metab. Clin. Exp. pmid:20934731
Pan Z et al. Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21295151
Tsubura A et al. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. 2011 Anticancer Agents Med Chem pmid:21269259
Chohany LE et al. Cationic substrates of soybean lipoxygenase-1. 2011 Bioorg. Chem. pmid:21257189
Liu WM et al. Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes. 2011 Mol. Cell. Biochem. pmid:21274596
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381