Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Andreu I et al. | Probing lipid peroxidation by using linoleic acid and benzophenone. | 2011 | Chemistry | pmid:21793062 |
Shibata H et al. | Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. | 2011 | Anim. Sci. J. | pmid:21794014 |
Gibson R and Makrides M | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22019216 |
Subbaiah PV et al. | Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. | 2011 | Biochim. Biophys. Acta | pmid:20920595 |
Liou AP et al. | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | 2011 | Gastroenterology | pmid:20955703 |
Das R et al. | Synthesis of linoleic acid capped copper nanoparticles and their fluorescence study. | 2011 | J Fluoresc | pmid:21221748 |
McCusker MM and Grant-Kels JM | Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. | 2010 Jul-Aug | Clin. Dermatol. | pmid:20620762 |
Zovko Koncić M et al. | Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20488218 |
Hajlaoui H et al. | Chemical composition and biological activities of Tunisian Cuminum cyminum L. essential oil: a high effectiveness against Vibrio spp. strains. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20488223 |
Frangioudakis G et al. | Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. | 2010 | Endocrinology | pmid:20660065 |
Castellanos P et al. | Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. | 2010 | Reprod. Toxicol. | pmid:20096347 |
Beevi SS et al. | Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. | 2010 | Plant Foods Hum Nutr | pmid:20072818 |
Ivanova L et al. | Phomenins and fatty acids from Alternaria infectoria. | 2010 | Toxicon | pmid:20060014 |
Won JC et al. | Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19965780 |
Dimri M et al. | Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. | 2010 | Carcinogenesis | pmid:19969553 |
Jernerén F et al. | Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. | 2010 | Biochim. Biophys. Acta | pmid:20045744 |
Paraszkiewicz K et al. | Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. | 2010 | Arch. Microbiol. | pmid:20047047 |
Esmaeili MA and Sonboli A | Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. | 2010 | Food Chem. Toxicol. | pmid:20036303 |
Li Y et al. | Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats. | 2010 | Br. J. Nutr. | pmid:20420751 |
Jernerén F et al. | Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. | 2010 | Arch. Biochem. Biophys. | pmid:20043865 |
Bradbury KE et al. | The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. | 2010 | Am. J. Clin. Nutr. | pmid:19955401 |
Lábaque MC et al. | Effect of age and body weight of Greater Rhea (Rhea americana) females on egg number, size and composition. | 2010 | Br. Poult. Sci. | pmid:21161792 |
Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
Zidi A et al. | Pleiotropic effects of the goat prolactin receptor genotype on milk fatty acid composition. | 2010 | Domest. Anim. Endocrinol. | pmid:20399061 |
Peoples GE and McLennan PL | Dietary fish oil reduces skeletal muscle oxygen consumption, provides fatigue resistance and improves contractile recovery in the rat in vivo hindlimb. | 2010 | Br. J. Nutr. | pmid:20691135 |
Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
Köse EO et al. | Chemical composition, antimicrobial and antioxidant activities of the essential oils of Sideritis erythrantha Boiss. and Heldr. (var. erythrantha and var. cedretorum P.H. Davis) endemic in Turkey. | 2010 | Food Chem. Toxicol. | pmid:20670669 |
Strandvik B | Fatty acid metabolism in cystic fibrosis. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20673710 |
Takahashi S et al. | The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20699562 |
Vij N | Linoleic acid supplement in cystic fibrosis: friend or foe? | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20709729 |
Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
Serhan Z et al. | Complete determination of natural site-specific enantio-isotopomeric excesses in linoleic acid using natural abundance deuterium 2D NMR in polypeptide mesophases. | 2010 | Chem. Commun. (Camb.) | pmid:20721385 |
Noel JT et al. | Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. | 2010 | PLoS ONE | pmid:20824208 |
Macouzet M et al. | Genetic and structural comparison of linoleate isomerases from selected food-grade bacteria. | 2010 | J. Appl. Microbiol. | pmid:20825518 |
Collin F et al. | Experimental evidence of the reciprocal oxidation of Bovine Serum Albumin and Linoleate in aqueous solution, initiated by HO* free radicals. | 2010 | Biochimie | pmid:20685376 |
Calder PC | The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? | 2010 | Br. J. Nutr. | pmid:21118616 |
Ramsden CE et al. | n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. | 2010 | Br. J. Nutr. | pmid:21118617 |
Safarinejad MR et al. | Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. | 2010 | Clin Nutr | pmid:19666200 |
Demir AS and Talpur FN | Chemoenzymatic conversion of linoleic acid into conjugated linoleic acid. | 2010 | J. Agric. Food Chem. | pmid:20058923 |
Aldai N et al. | Double-muscling character influences the trans-18:1 and conjugated linoleic acid profiles in concentrate-fed yearling bulls. | 2010 | Meat Sci. | pmid:20374865 |
Bitis L et al. | Flavonoids and antioxidant activity of Rosa agrestis leaves. | 2010 | Nat. Prod. Res. | pmid:20397108 |
Kamkar A et al. | The antioxidative effect of Iranian Mentha pulegium extracts and essential oil in sunflower oil. | 2010 | Food Chem. Toxicol. | pmid:20385193 |
Sarikurkcu C et al. | Essential oil composition and antioxidant activity of Thymus longicaulis C. Presl subsp. longicaulis var. longicaulis. | 2010 | Food Chem. Toxicol. | pmid:20385197 |
Litvinov D et al. | Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. | 2010 | Atherosclerosis | pmid:19880116 |
Friesen RW and Innis SM | Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. | 2010 | Am. J. Clin. Nutr. | pmid:19923368 |
Runyon JB et al. | Parasitism by Cuscuta pentagona sequentially induces JA and SA defence pathways in tomato. | 2010 | Plant Cell Environ. | pmid:19930126 |
Matsuoka T et al. | Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. | 2010 | Br. J. Cancer | pmid:20842125 |
Benammar C et al. | Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation. | 2010 | BMC Complement Altern Med | pmid:20868496 |
Lu X et al. | Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. | 2010 | Lipids Health Dis | pmid:20868498 |
Cannata S et al. | Effect of visual marbling on sensory properties and quality traits of pork loin. | 2010 | Meat Sci. | pmid:20416803 |