Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jung S et al. | Effect of dietary mixture of gallic acid and linoleic acid on antioxidative potential and quality of breast meat from broilers. | 2010 | Meat Sci. | pmid:20609528 |
| Ross RA et al. | Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20647558 |
| Ohmori H et al. | Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. | 2010 | Pathobiology | pmid:20616616 |
| Bartók T et al. | Identification of the first fumonisin mycotoxins with three acyl groups by ESI-ITMS and ESI-TOFMS following RP-HPLC separation: palmitoyl, linoleoyl and oleoyl EFB₠fumonisin isomers from a solid culture of Fusarium verticillioides. | 2010 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21108092 |
| Zaman MM et al. | Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20656894 |
| Frangioudakis G et al. | Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. | 2010 | Endocrinology | pmid:20660065 |
| Ivanova L et al. | Phomenins and fatty acids from Alternaria infectoria. | 2010 | Toxicon | pmid:20060014 |
| Won JC et al. | Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19965780 |
| Jernerén F et al. | Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. | 2010 | Biochim. Biophys. Acta | pmid:20045744 |
| Paraszkiewicz K et al. | Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. | 2010 | Arch. Microbiol. | pmid:20047047 |
| Esmaeili MA and Sonboli A | Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. | 2010 | Food Chem. Toxicol. | pmid:20036303 |
| Jernerén F et al. | Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. | 2010 | Arch. Biochem. Biophys. | pmid:20043865 |
| Bradbury KE et al. | The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. | 2010 | Am. J. Clin. Nutr. | pmid:19955401 |
| Lábaque MC et al. | Effect of age and body weight of Greater Rhea (Rhea americana) females on egg number, size and composition. | 2010 | Br. Poult. Sci. | pmid:21161792 |
| Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
| Zidi A et al. | Pleiotropic effects of the goat prolactin receptor genotype on milk fatty acid composition. | 2010 | Domest. Anim. Endocrinol. | pmid:20399061 |
| Peoples GE and McLennan PL | Dietary fish oil reduces skeletal muscle oxygen consumption, provides fatigue resistance and improves contractile recovery in the rat in vivo hindlimb. | 2010 | Br. J. Nutr. | pmid:20691135 |
| Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
| Köse EO et al. | Chemical composition, antimicrobial and antioxidant activities of the essential oils of Sideritis erythrantha Boiss. and Heldr. (var. erythrantha and var. cedretorum P.H. Davis) endemic in Turkey. | 2010 | Food Chem. Toxicol. | pmid:20670669 |
| Strandvik B | Fatty acid metabolism in cystic fibrosis. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20673710 |
| Takahashi S et al. | The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20699562 |
| Vij N | Linoleic acid supplement in cystic fibrosis: friend or foe? | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20709729 |
| Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
| Noel JT et al. | Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. | 2010 | PLoS ONE | pmid:20824208 |
| Macouzet M et al. | Genetic and structural comparison of linoleate isomerases from selected food-grade bacteria. | 2010 | J. Appl. Microbiol. | pmid:20825518 |
| Collin F et al. | Experimental evidence of the reciprocal oxidation of Bovine Serum Albumin and Linoleate in aqueous solution, initiated by HO* free radicals. | 2010 | Biochimie | pmid:20685376 |
| Calder PC | The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? | 2010 | Br. J. Nutr. | pmid:21118616 |
| Ramsden CE et al. | n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. | 2010 | Br. J. Nutr. | pmid:21118617 |
| Guo JJ and Hu CH | Mechanism of chain termination in lipid peroxidation by carotenes: a theoretical study. | 2010 | J Phys Chem B | pmid:21105679 |
| Safarinejad MR et al. | Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. | 2010 | Clin Nutr | pmid:19666200 |
| Demir AS and Talpur FN | Chemoenzymatic conversion of linoleic acid into conjugated linoleic acid. | 2010 | J. Agric. Food Chem. | pmid:20058923 |
| Tume RK et al. | Enriching M. sternomandibularis with alpha-tocopherol by dietary means does not protect against the lipid oxidation caused by high-pressure processing. | 2010 | Meat Sci. | pmid:20374755 |
| Berthelot V et al. | Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. | 2010 | Meat Sci. | pmid:20374762 |
| Della Casa G et al. | Performance and fat quality of heavy pigs fed maize differing in linoleic acid content. | 2010 | Meat Sci. | pmid:20374768 |
| Aldai N et al. | Double-muscling character influences the trans-18:1 and conjugated linoleic acid profiles in concentrate-fed yearling bulls. | 2010 | Meat Sci. | pmid:20374865 |
| Bitis L et al. | Flavonoids and antioxidant activity of Rosa agrestis leaves. | 2010 | Nat. Prod. Res. | pmid:20397108 |
| Kamkar A et al. | The antioxidative effect of Iranian Mentha pulegium extracts and essential oil in sunflower oil. | 2010 | Food Chem. Toxicol. | pmid:20385193 |
| Sarikurkcu C et al. | Essential oil composition and antioxidant activity of Thymus longicaulis C. Presl subsp. longicaulis var. longicaulis. | 2010 | Food Chem. Toxicol. | pmid:20385197 |
| Litvinov D et al. | Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. | 2010 | Atherosclerosis | pmid:19880116 |
| Friesen RW and Innis SM | Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. | 2010 | Am. J. Clin. Nutr. | pmid:19923368 |
| Runyon JB et al. | Parasitism by Cuscuta pentagona sequentially induces JA and SA defence pathways in tomato. | 2010 | Plant Cell Environ. | pmid:19930126 |
| Matsuoka T et al. | Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. | 2010 | Br. J. Cancer | pmid:20842125 |
| Benammar C et al. | Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation. | 2010 | BMC Complement Altern Med | pmid:20868496 |
| Lu X et al. | Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. | 2010 | Lipids Health Dis | pmid:20868498 |
| Cannata S et al. | Effect of visual marbling on sensory properties and quality traits of pork loin. | 2010 | Meat Sci. | pmid:20416803 |
| Habermann N et al. | Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. | 2009 Sep-Oct | Biofactors | pmid:19798733 |
| Yu C et al. | Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19648018 |
| Kawakami Y et al. | Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. | 2009 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19457650 |
| Parnas M et al. | Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action. | 2009 May-Jun | Channels (Austin) | pmid:19535910 |
| Zeng Z et al. | Identification of lactic acid bacterial strains with high conjugated linoleic acid-producing ability from natural sauerkraut fermentations. | 2009 May-Jul | J. Food Sci. | pmid:19490332 |