Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
Rosenfield RL et al. | Mechanisms of androgen induction of sebocyte differentiation. | 1998 | Dermatology (Basel) | pmid:9557223 |
Akamatsu H and Horio T | The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. | 1998 | Dermatology (Basel) | pmid:9557235 |
Kowaltowski AJ et al. | Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. | 1998 | FEBS Lett. | pmid:9559650 |
Yehuda S et al. | Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. | 1998 | Neurochem. Res. | pmid:9566600 |
Marra F et al. | Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. | 1998 | J. Hepatol. | pmid:9566835 |
Kelly ML et al. | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. | 1998 | J. Nutr. | pmid:9566998 |
Hill EM et al. | Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9569236 |
Lee M et al. | Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation. | 1998 | Science | pmid:9572738 |
Hamberg M et al. | Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction. | 1998 | J. Biol. Chem. | pmid:9582346 |
Peterson DB | Long-chain fatty acids and cardiovascular disease risk in non-insulin-dependent diabetes. | 1998 | Nutrition | pmid:9583379 |
Kambayashi Y et al. | Preferential hydrolysis of oxidized phosphatidylcholine in cholesterol-containing phosphatidylcholine liposome by phospholipase A2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9588178 |
Dokko RC et al. | Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. | 1998 | Int. J. Biochem. Cell Biol. | pmid:9597754 |
Schaloske R et al. | Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum. | 1998 | Biochem. J. | pmid:9601085 |
Geetha T et al. | Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats. | 1998 | Pharmacol. Res. | pmid:9602466 |
Kleinfeld AM et al. | Transport of long-chain native fatty acids across human erythrocyte ghost membranes. | 1998 | Biochemistry | pmid:9609694 |
Das I and Khan NS | Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610837 |
Kikuchi S et al. | Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610849 |
Ohnishi M et al. | Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. | 1998 | Phytochemistry | pmid:9611825 |
Liu KL and Belury MA | Conjugated linoleic acid reduces arachidonic acid content and PGE2 synthesis in murine keratinocytes. | 1998 | Cancer Lett. | pmid:9619853 |