Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
KmonÃcková E et al. | Differences in heart phospholipids in two inbred rat strains differing in sensitivity to the development of heart lesions. | 1998 | Physiol Res | pmid:9706993 |
Ondrias K et al. | Antioxidant and pro-oxidant effects of epinephrine and isoprenaline on peroxidation of LDL and lipid liposomes. | 1998 | Physiol Res | pmid:9706995 |
Butovich IA et al. | Oxidation of linoleyl alcohol by potato tuber lipoxygenase: possible mechanism and the role of carboxylic group in substrate binding. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9712698 |
Konrad SD et al. | Use of deuterium oxide to measure de novo fatty acid synthesis in normal subjects consuming different dietary fatty acid composition1. | 1998 | Biochim. Biophys. Acta | pmid:9714781 |
Ryu SB and Wang X | Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. | 1998 | Biochim. Biophys. Acta | pmid:9714802 |
West DB et al. | Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. | 1998 | Am. J. Physiol. | pmid:9728060 |
Wilson TA et al. | Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: beyond linoleate. | 1998 | Atherosclerosis | pmid:9733225 |
Sentex E et al. | Is the cytoprotective effect of trimetazidine associated with lipid metabolism? | 1998 | Am. J. Cardiol. | pmid:9737482 |
Fidler N et al. | Effects of human milk pasteurization and sterilization on available fat content and fatty acid composition. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9740204 |
Liu JH et al. | Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. | 1998 | Planta Med. | pmid:9741298 |
Rodriguez A et al. | Delta6- and delta5-desaturase activities in the human fetal liver: kinetic aspects. | 1998 | J. Lipid Res. | pmid:9741695 |
Sluse FE et al. | Free fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria. | 1998 | FEBS Lett. | pmid:9744802 |
Romijn D et al. | A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. | 1998 | Ann. Nutr. Metab. | pmid:9745111 |
Berdeaux O et al. | In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes. | 1998 | Mol. Cell. Biochem. | pmid:9746207 |
Kanazawa K and Ashida H | Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. | 1998 | Biochim. Biophys. Acta | pmid:9748647 |
Kanazawa K and Ashida H | Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. | 1998 | Biochim. Biophys. Acta | pmid:9748650 |
Kuratko CN and Constante BJ | Linoleic acid and tumor necrosis factor-alpha increase manganese superoxide dismutase activity in intestinal cells. | 1998 | Cancer Lett. | pmid:9751273 |
Spalinger JH et al. | Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. | 1998 | Am. J. Physiol. | pmid:9756493 |
Obukowicz MG et al. | Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9765335 |
Iwamoto S et al. | Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. | 1998 | Nutr Cancer | pmid:9770727 |