| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rosenthal MD and Whitehurst MC | Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. | 1983 | Biochim. Biophys. Acta | pmid:6297606 |
| Oliw EH | Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6301473 |
| Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
| Rustin P et al. | Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mitochondria. | 1983 | Arch. Biochem. Biophys. | pmid:6414377 |
| Campbell TB and Lueking DR | Long-chain fatty acid assimilation By rhodopseudomonas sphaeroides. | 1983 | J. Bacteriol. | pmid:6600450 |
| Nicholson T and Omer SA | The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. | 1983 | Zentralbl Veterinarmed A | pmid:6318476 |
| Spector AA et al. | Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells. | 1983 | J. Lipid Res. | pmid:6321621 |
| Sanders TA | Dietary fat and platelet function. | 1983 | Clin. Sci. | pmid:6309463 |
| Goldmacher VS | Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. | 1983 | Biochem. Pharmacol. | pmid:6189496 |
| Gerzer R et al. | Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6134818 |
| Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
| Lloyd D et al. | Adaptive changes in yeast membranes: catabolite repression and oxygen. | 1983 | Biochem. Soc. Trans. | pmid:6617968 |
| Kreutter D et al. | The effect of essential fatty acid deficiency on the stimulation of intestinal calcium transport by 1,25-dihydroxyvitamin D3. | 1983 | J. Biol. Chem. | pmid:6687596 |
| Rapp JH et al. | Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression. | 1983 | J. Lipid Res. | pmid:6644183 |
| MacDonald ML et al. | Role of linoleate as an essential fatty acid for the cat independent of arachidonate synthesis. | 1983 | J. Nutr. | pmid:6408230 |
| Gavigan SJ and Knight BL | The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. | 1983 | Biochem. J. | pmid:6651782 |
| Hoover RL et al. | Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes. | 1983 | J. Cell Biol. | pmid:6223042 |
| Greenway DL and Dyke KG | The effect of membrane-bound beta-lactamase on linoleic acid sensitivity in Staphylococcus aureus. | 1983 | J. Gen. Microbiol. | pmid:6605415 |
| Shultz TD and Leklem JE | Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. | 1983 | Am. J. Clin. Nutr. | pmid:6849273 |
| Arudi RL et al. | Purification of oleic acid and linoleic acid. | 1983 | J. Lipid Res. | pmid:6854155 |
| Ookhtens M and Baker N | Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. | 1983 | Am. J. Physiol. | pmid:6295191 |
| Hoffmann P et al. | Impaired catecholamine inactivation. A prohypertensive stimulus after dietary linoleate deficiency in salt-loaded rats? | 1983 Nov-Dec | Hypertension | pmid:6581124 |
| Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
| Dworkin RH et al. | Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. | 1984 | Neurology | pmid:6387534 |
| Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
| Sakaguchi M et al. | Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. | 1984 | Cancer Res. | pmid:6704963 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Van Alstine JM and Brooks DE | Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. | 1984 | Clin. Chem. | pmid:6199135 |
| Benaim G et al. | Different conformational states of the purified Ca2+-ATPase of the erythrocyte plasma membrane revealed by controlled trypsin proteolysis. | 1984 | J. Biol. Chem. | pmid:6234313 |
| Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
| Schick PK et al. | Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. | 1984 | Biochim. Biophys. Acta | pmid:6433984 |
| Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
| Inouye S | Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid. | 1984 | FEBS Lett. | pmid:6430718 |
| Ramesha CS and Thompson GA | The mechanism of membrane response to chilling. Effect of temperature on phospholipid deacylation and reacylation reactions in the cell surface membrane. | 1984 | J. Biol. Chem. | pmid:6430890 |
| Kitagawa S et al. | Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. | 1984 | Biochim. Biophys. Acta | pmid:6435686 |
| Becker W | Distribution of 14C after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. | 1984 | J. Nutr. | pmid:6470826 |
| Neufeld EJ et al. | A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase. | 1984 | J. Biol. Chem. | pmid:6420417 |
| Heine RJ et al. | The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. | 1984 | Ann. Nutr. Metab. | pmid:6476785 |
| Adam O and Wolfram G | Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man. | 1984 | Am. J. Clin. Nutr. | pmid:6486083 |
| Badwey JA et al. | Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. | 1984 | J. Biol. Chem. | pmid:6330088 |
| Jacobs JM and Jacobs NJ | Effect of unsaturated fatty acids on protoporphyrinogen oxidation, a step in heme and chlorophyll synthesis in plant organelles. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6487324 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Arslan P et al. | cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. | 1984 | Biochem. J. | pmid:6696740 |
| Stymne S and Stobart AK | The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). | 1984 | Biochem. J. | pmid:6743281 |
| Colard O et al. | 1-Acyl-lysolecithin acyltransferase and synthesis of biliary lecithins in rat liver. | 1984 | Biochimie | pmid:6743697 |
| Margetts BM et al. | Dietary fats and blood pressure. | 1984 | Aust N Z J Med | pmid:6596055 |
| Eyssen H and Verhulst A | Biotransformation of linoleic acid and bile acids by Eubacterium lentum. | 1984 | Appl. Environ. Microbiol. | pmid:6582800 |
| Chapkin RS and Ziboh VA | Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6439197 |
| Iversen SA et al. | Identification of a diene conjugated component of human lipid as octadeca-9,11-dienoic acid. | 1984 | FEBS Lett. | pmid:6723989 |
| Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |