| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Baykousheva S | Metabolism of [1-14C]linoleic acid in human promyelocytic leukemia HL-60 cells grown and differentiated in serum-free medium. | 1993 | Cancer Lett. | pmid:8402565 |
| Hatala MA et al. | Characterization of phospholipase A2 activity in MDA-MB-435 human breast cancer cells. | 1993 | Cancer Lett. | pmid:8402571 |
| Toborek M and Hennig B | Vitamin E attenuates induction of elastase-like activity by tumor necrosis factor-alpha, cholestan-3 beta,5 alpha,6 beta-triol and linoleic acid in cultured endothelial cells. | 1993 | Clin. Chim. Acta | pmid:8403435 |
| Kleinveld HA et al. | Oxidation resistance, oxidation rate, and extent of oxidation of human low-density lipoprotein depend on the ratio of oleic acid content to linoleic acid content: studies in vitamin E deficient subjects. | 1993 | Free Radic. Biol. Med. | pmid:8406127 |
| Keler T and Sorof S | Growth promotion of transfected hepatoma cells by liver fatty acid binding protein. | 1993 | J. Cell. Physiol. | pmid:8408240 |
| Seidelin KN et al. | Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease. | 1993 | Am. J. Clin. Nutr. | pmid:8416668 |
| de Waard P et al. | Heteronuclear NMR analysis of unsaturated fatty acids in poly(3-hydroxyalkanoates). Study of beta-oxidation in Pseudomonas putida. | 1993 | J. Biol. Chem. | pmid:8416939 |
| Cominacini L et al. | Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. | 1993 | Biochim. Biophys. Acta | pmid:8418885 |
| Blair IA et al. | Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. | 1993 | Am. J. Clin. Nutr. | pmid:8424383 |
| Oliw EH et al. | Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids. | 1993 | Arch. Biochem. Biophys. | pmid:8424677 |
| Deigner HP and Dresel HA | Effect of platelet activating factor on the kinetics of LDL oxidation in vitro. | 1993 | FEBS Lett. | pmid:8425606 |
| Reaven P et al. | Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects. | 1993 | J. Clin. Invest. | pmid:8432867 |
| Callaghan R et al. | Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. | 1993 | Biochim. Biophys. Acta | pmid:8435444 |
| Abbey M et al. | Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. | 1993 | Am. J. Clin. Nutr. | pmid:8438773 |
| Jones AL et al. | Temperature-induced membrane-lipid adaptation in Acanthamoeba castellanii. | 1993 | Biochem. J. | pmid:8439295 |
| Terada N et al. | Definition of the roles for iron and essential fatty acids in cell cycle progression of normal human T lymphocytes. | 1993 | Exp. Cell Res. | pmid:8440323 |
| Batna A et al. | The occurrence of furan fatty acids in Isochrysis sp. and Phaeodactylum tricornutum. | 1993 | Biochim. Biophys. Acta | pmid:8443233 |
| Oliw EH | bis-Allylic hydroxylation of linoleic acid and arachidonic acid by human hepatic monooxygenases. | 1993 | Biochim. Biophys. Acta | pmid:8443245 |
| Band AM et al. | The mechanism of arachidonic acid-induced insulin secretion from rat islets of Langerhans. | 1993 | Biochim. Biophys. Acta | pmid:8452880 |
| Vaughan PF et al. | Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y. | 1993 | J. Neurochem. | pmid:8455030 |
| Lecerf J et al. | Variations in the fatty acid composition of lipid classes from lipoproteins in elderly women. | 1993 | Atherosclerosis | pmid:8457263 |
| van Haaster CM et al. | Formation of prostanoids and hydroxy fatty acids by stimulated peritoneal mast cells: role of the dietary fat type in rat. | 1993 | Biochim. Biophys. Acta | pmid:8466942 |
| Lomnitski L et al. | The interaction between beta-carotene and lipoxygenase in plant and animal systems. | 1993 | Biochim. Biophys. Acta | pmid:8481396 |
| Püttmann M et al. | Fast HPLC determination of serum free fatty acids in the picomole range. | 1993 | Clin. Chem. | pmid:8485873 |
| Sugano M and Koba K | Dietary protein and lipid metabolism: a multifunctional effect. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8489133 |
| Bafor M et al. | Biosynthesis of vernoleate (cis-12-epoxyoctadeca-cis-9-enoate) in microsomal preparations from developing endosperm of Euphorbia lagascae. | 1993 | Arch. Biochem. Biophys. | pmid:8489257 |
| Naval J et al. | Alternative route for the biosynthesis of polyunsaturated fatty acids in K562 cells. | 1993 | Biochem. J. | pmid:8489510 |
| Wey HE et al. | Essential fatty acid deficiency in cultured human keratinocytes attenuates toxicity due to lipid peroxidation. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8511784 |
| Thompson RL et al. | Cigarette smoking, polyunsaturated fats, and coronary heart disease. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8512244 |
| Hudson EA et al. | Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid. | 1993 | Biochem. Pharmacol. | pmid:8517859 |
| Osawa T et al. | Antioxidative activity of tetrahydrocurcuminoids. | 1995 | Biosci. Biotechnol. Biochem. | pmid:8520105 |
| Nishio H and Mori K | Reinvestigation of the structure of the esterified cerebroside in the epidermis of guinea pigs. | 1995 | Biosci. Biotechnol. Biochem. | pmid:8520108 |
| Arnhold J et al. | The action of hypochlorous acid on phosphatidylcholine liposomes in dependence on the content of double bonds. Stoichiometry and NMR analysis. | 1995 | Chem. Phys. Lipids | pmid:8521532 |
| Abushufa R et al. | Essential fatty acid status in patients on long-term home parenteral nutrition. | 1995 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:8523627 |
| Shen J et al. | Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme. | 1995 | FASEB J. | pmid:8529842 |
| Wiseman SA et al. | Comparison of the effects of dietary vitamin E on in vivo and in vitro parameters of lipid peroxidation in the rabbit. | 1995 | Free Radic. Biol. Med. | pmid:8529921 |
| Groves BA | Exit linoleic acid too? | 1996 | Lancet | pmid:8531562 |
| Antras-Ferry J et al. | Fatty acids and fibrates are potent inducers of transcription of the phosphenolpyruvate carboxykinase gene in adipocytes. | 1995 | Eur. J. Biochem. | pmid:8536680 |
| Siguel EN and Lerman RH | Prevalence of essential fatty acid deficiency in patients with chronic gastrointestinal disorders. | 1996 | Metab. Clin. Exp. | pmid:8544768 |
| Ivanetich KM et al. | Delta 6-desaturase: improved methodology and analysis of the kinetics in a multi-enzyme system. | 1996 | Biochim. Biophys. Acta | pmid:8547334 |
| Mirzoeva OK et al. | Competitive inhibition of the 5-lipoxygenase-catalysed linoleate oxidation by arachidonic and 5-hydroperoxy-eicosatetraenoic acids. | 1995 | FEBS Lett. | pmid:8549743 |
| Bauldry SA et al. | Activation of cytosolic phospholipase A2 in permeabilized human neutrophils. | 1996 | Biochim. Biophys. Acta | pmid:8555268 |
| Luthria DL and Sprecher H | Metabolism of deuterium-labeled linoleic, 6,9,12-octadecatrienoic, 8,11,14-eicosatrienoic, and arachidonic acids in the rat. | 1995 | J. Lipid Res. | pmid:8558078 |
| Heiskanen K et al. | Interactions of cis-fatty acids and their anilides with formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate and dioctanoyl-s,n-glycerol in human leukocytes. | 1995 | Toxicology | pmid:8560489 |
| Ghusain-Choueiri AA and Rath EA | Effect of carbohydrate source on lipid metabolism in lactating mice and on pup development. | 1995 | Br. J. Nutr. | pmid:8562569 |
| Demmelmair H et al. | Estimation of arachidonic acid synthesis in full term neonates using natural variation of 13C content. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:8576811 |
| Abdel Baset H et al. | Characterization of arachidonic-acid-metabolizing enzymes in adult Schistisoma mansoni. | 1995 | Mol. Biochem. Parasitol. | pmid:8577345 |
| Ritenbaugh C et al. | Risk factors for Barrett's oesophagus: a life history approach to behavioural assessment in the distant past. | 1995 | Eur. J. Cancer Prev. | pmid:8580781 |
| Boscá F et al. | Evaluation of ketoprofen (R,S and R/S) phototoxicity by a battery of in vitro assays. | 1995 | J. Photochem. Photobiol. B, Biol. | pmid:8583281 |
| Fuhrmann H and Sallmann HP | Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:8585700 |