Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pareja A et al. | Unsaturated fatty acids alter the insulin secretion response of the islets of Langerhans in vitro. | 1997 | Diabetes Res. Clin. Pract. | pmid:9483379 |
Bogdanov KY et al. | Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. | 1998 | Am. J. Physiol. | pmid:9486261 |
Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
Bremmer DR et al. | Effects of chain length and unsaturation of fatty acid mixtures infused into the abomasum of lactating dairy cows. | 1998 | J. Dairy Sci. | pmid:9493093 |
Yehuda S et al. | Fatty acids and brain peptides. | 1998 | Peptides | pmid:9493877 |
Saha SK et al. | Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. | 1997 | Jpn. J. Physiol. | pmid:9504135 |
Dänicke S et al. | Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. | 1997 | Br. Poult. Sci. | pmid:9511000 |
Freyaldenhoven MA et al. | Retinoic acid-dependent stimulation of 2,2'-azobis(2-amidinopropane)-initiated autoxidation of linoleic acid in sodium dodecyl sulfate micelles: a novel prooxidant effect of retinoic acid. | 1998 | Chem. Res. Toxicol. | pmid:9511901 |
Jiang WG et al. | The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. | 1998 | Br. J. Cancer | pmid:9514051 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Böhmer S et al. | Oxidation of phenanthrene by a fungal laccase in the presence of 1-hydroxybenzotriazole and unsaturated lipids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514895 |
Jiang WG et al. | Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514943 |
Oh-hashi K et al. | Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9524928 |
Liang JF and Akaike T | Protective effect of linoleic acid on IFN gamma-induced cellular injury in primary culture hepatocytes. | 1998 | J. Biochem. | pmid:9538194 |
Herrera JA et al. | Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. | 1998 | Obstet Gynecol | pmid:9540946 |
Voskuyl RA et al. | Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. | 1998 | Eur. J. Pharmacol. | pmid:9543232 |
Matthys LA and Widmaier EP | Fatty acids inhibit adrenocorticotropin-induced adrenal steroidogenesis. | 1998 | Horm. Metab. Res. | pmid:9543689 |
Liu SX et al. | Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. | 1998 | Atherosclerosis | pmid:9544730 |
Li-Stiles B et al. | Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes. | 1998 | J. Lipid Res. | pmid:9548589 |
Kataoka K et al. | Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. | 1998 | Pancreas | pmid:9548669 |