Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Genetic Diseases, X-Linked D040181 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Melanosis D008548 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Otitis Externa D010032 8 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Aortic Diseases D001018 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Glucose Intolerance D018149 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Alopecia D000505 14 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Tuberculosis D014376 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Birth Weight D001724 23 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Diseases D008107 31 associated lipids
Heart Failure D006333 36 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Fatty Liver D005234 48 associated lipids
Precancerous Conditions D011230 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
CHRISTAKIS GJ et al. EFFECT OF A SERUM CHOLESTEROL-LOWERING DIET ON COMPOSITION OF DEPOT FAT IN MAN. 1965 Am. J. Clin. Nutr. pmid:14253897
ZUKEL MC FAT-CONTROLLED DIETS. 1965 Am. J. Clin. Nutr. pmid:14253901
Brynes AE et al. Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. 2000 Am. J. Clin. Nutr. pmid:11063437
Higdon JV et al. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. 2000 Am. J. Clin. Nutr. pmid:10966889
CAMPBELL AM et al. SERUM LIPIDS OF MEN FED DIETS DIFFERING IN PROTEIN QUALITY AND LINOLEIC ACID CONTENT. 1965 Am. J. Clin. Nutr. pmid:14332349
Bjerve KS et al. Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. 1987 Am. J. Clin. Nutr. pmid:3310599
Hennig B et al. Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. 1996 Am. J. Clin. Nutr. pmid:8602587
Kark JD et al. Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. 2003 Am. J. Clin. Nutr. pmid:12663274
Djoussé L et al. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:12663278
Routi T et al. Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. 1996 Am. J. Clin. Nutr. pmid:8602597
Glatz JF et al. Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. 1989 Am. J. Clin. Nutr. pmid:2916448
Louheranta AM et al. Linoleic acid intake and susceptibility of very-low-density and low density lipoproteins to oxidation in men. 1996 Am. J. Clin. Nutr. pmid:8615351
KRAUSE RF LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A. 1965 Am. J. Clin. Nutr. pmid:14301352
van Egmond AW et al. Effect of linoleic acid intake on growth of infants with cystic fibrosis. 1996 Am. J. Clin. Nutr. pmid:8615359
Anderson RL Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. 1982 Am. J. Clin. Nutr. pmid:7081132
Turpeinen AM et al. Bioconversion of vaccenic acid to conjugated linoleic acid in humans. 2002 Am. J. Clin. Nutr. pmid:12197992
Martinelli N et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. 2008 Am. J. Clin. Nutr. pmid:18842780
Hennig B and Watkins BA Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. 1989 Am. J. Clin. Nutr. pmid:2563626
SCOTT RF et al. FATTY ACIDS OF SERUM AND ADIPOSE TISSUE IN SIX GROUPS EATING NATURAL DIETS CONTAINING 7 TO 40 PER CENT FAT. 1964 Am. J. Clin. Nutr. pmid:14157830
DeLany JP et al. Differential oxidation of individual dietary fatty acids in humans. 2000 Am. J. Clin. Nutr. pmid:11010930
Mantzioris E et al. Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. 1995 Am. J. Clin. Nutr. pmid:7840069
Siguel E Does linoleic acid contribute to coronary artery disease? 1995 Am. J. Clin. Nutr. pmid:7840081
Innis SM and Elias SL Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. 2003 Am. J. Clin. Nutr. pmid:12540410
Vos E and Cunnane SC Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. 2003 Am. J. Clin. Nutr. pmid:12540417
Gillingham LG et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 2013 Am. J. Clin. Nutr. pmid:23221573
O'Connell ED et al. Diet and risk factors for age-related maculopathy. 2008 Am. J. Clin. Nutr. pmid:18326611
Villalpando S et al. [13C]linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes. 2001 Am. J. Clin. Nutr. pmid:11729835
Anderson GJ and Connor WE On the demonstration of omega-3 essential-fatty-acid deficiency in humans. 1989 Am. J. Clin. Nutr. pmid:2494878
Jannace PW et al. Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes. 1992 Am. J. Clin. Nutr. pmid:1323926
Decsi T et al. Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. 1995 Am. J. Clin. Nutr. pmid:7491893
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
Hrboticky N et al. Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. 1991 Am. J. Clin. Nutr. pmid:1989416
Martin JC et al. Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. 1991 Am. J. Clin. Nutr. pmid:1951153
Del Prado M et al. Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. 2001 Am. J. Clin. Nutr. pmid:11470727
CENTURY B et al. INTERRELATIONSHIPS OF DIETARY LIPIDS UPON FATTY ACID COMPOSITION OF BRAIN MITOCHONDRIA, ERYTHROCYTES AND HEART TISSUE IN CHICKS. 1963 Am. J. Clin. Nutr. pmid:14101397
Carnielli VP et al. Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. 1996 Am. J. Clin. Nutr. pmid:8694014
Erickson KL Is there a relation between dietary linoleic acid and cancer of the breast, colon, or prostate? 1998 Am. J. Clin. Nutr. pmid:9665090
Vedtofte MS et al. Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. 2011 Am. J. Clin. Nutr. pmid:21865326
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Rioux FM and Innis SM Arachidonic acid concentrations in plasma and liver phospholipid and cholesterol esters of piglets raised on formulas with different linoleic and linolenic acid contents. 1992 Am. J. Clin. Nutr. pmid:1609747
HOLMAN RT et al. ESTIMATION OF LINOLEATE INTAKE OF MEN FROM SERUM LIPID ANALYSIS. 1964 Am. J. Clin. Nutr. pmid:14142377
MACDONALD I and BARRY PJ CHANGES IN THE FATTY ACID PATTERN OF THE ADIPOSE TISSUE OF OBESE SUBJECTS WHILE ON A REDUCING REGIMEN. 1964 Am. J. Clin. Nutr. pmid:14212750
Rudel LL et al. Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. 1995 Am. J. Clin. Nutr. pmid:7625361
PINTER KG et al. FAT ABSORPTION STUDIES IN VARIOUS FORMS OF STEATORRHEA. 1964 Am. J. Clin. Nutr. pmid:14220479
Cunnane SC et al. Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. 1989 Am. J. Clin. Nutr. pmid:2801584
Herbel BK et al. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. 1998 Am. J. Clin. Nutr. pmid:9459383
Reeves VB et al. Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. 1984 Am. J. Clin. Nutr. pmid:6507356
Green P et al. Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. 1990 Am. J. Clin. Nutr. pmid:2239789
Meerarani P et al. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. 2000 Am. J. Clin. Nutr. pmid:10617950
Sanders TA Polyunsaturated fatty acids in the food chain in Europe. 2000 Am. J. Clin. Nutr. pmid:10617968
Uauy R and Hoffman DR Essential fat requirements of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617979
Kinsella JE et al. Metabolism of trans fatty acids with emphasis on the effects of trans, trans-octadecadienoate on lipid composition, essential fatty acid, and prostaglandins: an overview. 1981 Am. J. Clin. Nutr. pmid:6794350
Gibson RA and Makrides M n-3 polyunsaturated fatty acid requirements of term infants. 2000 Am. J. Clin. Nutr. pmid:10617980
Crawford M Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617983
Adam O and Wolfram G Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man. 1984 Am. J. Clin. Nutr. pmid:6486083
Dutta-Roy AK Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. 2000 Am. J. Clin. Nutr. pmid:10617989
Blair IA et al. Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. 1993 Am. J. Clin. Nutr. pmid:8424383
Ziboh VA et al. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. 2000 Am. J. Clin. Nutr. pmid:10617998
Horrobin DF Essential fatty acid metabolism and its modification in atopic eczema. 2000 Am. J. Clin. Nutr. pmid:10617999
Weaver BJ et al. Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. 1990 Am. J. Clin. Nutr. pmid:2181858
Kalivianakis M et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. 1999 Am. J. Clin. Nutr. pmid:9925134
SINGLETON WS CHARACTERIZED OILS FOR USE IN INTRAVENOUS FAT EMULSIONS. 1965 Am. J. Clin. Nutr. pmid:14262113
Hodgson JM et al. Can linoleic acid contribute to coronary artery disease? 1993 Am. J. Clin. Nutr. pmid:8192728
Truswell AS Can linoleic acid contribute to coronary artery disease? 1994 Am. J. Clin. Nutr. pmid:8198070
James MJ et al. Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma. 1993 Am. J. Clin. Nutr. pmid:8379505
Innis SM and Hansen JW Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. 1996 Am. J. Clin. Nutr. pmid:8694015
Reaven P et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. 1991 Am. J. Clin. Nutr. pmid:1897476
Iacono JM and Dougherty RM Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. 1991 Am. J. Clin. Nutr. pmid:1900384
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Murphy J et al. Fat malabsorption in cystic fibrosis patients. 1999 Am. J. Clin. Nutr. pmid:10539762
Warensjö E et al. Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. 2006 Am. J. Clin. Nutr. pmid:16895896
Burri BJ et al. Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. 1991 Am. J. Clin. Nutr. pmid:1858699
Freese R et al. High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects. 2002 Am. J. Clin. Nutr. pmid:12399265
Blasbalg TL et al. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. 2011 Am. J. Clin. Nutr. pmid:21367944
Asciutti-Moura LS et al. Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. 1988 Am. J. Clin. Nutr. pmid:3421207
Terpstra AH Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. 2004 Am. J. Clin. Nutr. pmid:14985207
Cunnane SC Diodoquin and linoleic acid absorption in zinc deficiency. 1981 Am. J. Clin. Nutr. pmid:6792900
Rose DP Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. 1997 Am. J. Clin. Nutr. pmid:9394709
Salem N and Kuratko CN Lack of evidence for increased α-linolenic acid metabolism in vegetarians. 2011 Am. J. Clin. Nutr. pmid:21430120
Ip C Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. 1997 Am. J. Clin. Nutr. pmid:9394710
Willett WC Specific fatty acids and risks of breast and prostate cancer: dietary intake. 1997 Am. J. Clin. Nutr. pmid:9394715
Friesen RW and Innis SM Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. 2010 Am. J. Clin. Nutr. pmid:19923368
Goyens PL et al. Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. 2006 Am. J. Clin. Nutr. pmid:16825680
Abbey M et al. Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. 1993 Am. J. Clin. Nutr. pmid:8438773
Venäläinen TM et al. Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. 2016 Am. J. Clin. Nutr. pmid:27581473
McMurchie EJ et al. Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. 1984 Am. J. Clin. Nutr. pmid:6720626
Almario RU et al. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. 2001 Am. J. Clin. Nutr. pmid:11451720
Makrides M et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. 1994 Am. J. Clin. Nutr. pmid:7913291
Shultz TD and Leklem JE Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. 1983 Am. J. Clin. Nutr. pmid:6849273
Cunnane SC et al. Beta-oxidation of linoleate in obese men undergoing weight loss. 2001 Am. J. Clin. Nutr. pmid:11273844
Elias SL and Innis SM Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. 2001 Am. J. Clin. Nutr. pmid:11273857
Freeman VL et al. Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? 2001 Am. J. Clin. Nutr. pmid:11273858
Seidelin KN et al. Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease. 1993 Am. J. Clin. Nutr. pmid:8416668
Larbi A et al. Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans. 2005 Am. J. Clin. Nutr. pmid:16280424
OLSON FE et al. The use of diets containing large amounts of linoleic acid. 1958 Nov-Dec Am. J. Clin. Nutr. pmid:13594895
Mahendran Y et al. Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. 2014 Am. J. Clin. Nutr. pmid:24153340
Nestel PJ et al. Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations. 1998 Am. J. Clin. Nutr. pmid:9846846
Hodge AM et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. 2007 Am. J. Clin. Nutr. pmid:17616780
Yary T et al. Serum n-6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. 2016 Am. J. Clin. Nutr. pmid:27009754
Arca M et al. Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. 1987 Am. J. Clin. Nutr. pmid:3604961