Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia D007938 74 associated lipids
Coronary Disease D003327 70 associated lipids
Colitis D003092 69 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pain D010146 64 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Thrombosis D013927 49 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Heart Failure D006333 36 associated lipids
Liver Diseases D008107 31 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Birth Weight D001724 23 associated lipids
Helicobacter Infections D016481 21 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Tuberculosis D014376 20 associated lipids
Olfaction Disorders D000857 17 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Alopecia D000505 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Salama el-S et al. Biomass, lipid content, and fatty acid composition of freshwater Chlamydomonas mexicana and Scenedesmus obliquus grown under salt stress. 2013 Bioprocess Biosyst Eng pmid:23411874
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Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
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Adachi S et al. Increased levels of extracellular dopamine in the nucleus accumbens and amygdala of rats by ingesting a low concentration of a long-chain Fatty Acid. 2013 Biosci. Biotechnol. Biochem. pmid:24200795
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Cortie CH and Else PL Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications. 2012 Int J Mol Sci pmid:23203135
O'Donnell-Megaro AM et al. Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. 2012 J. Dairy Sci. pmid:23063161
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Martorell P et al. Caenorhabditis elegans as a model to study the effectiveness and metabolic targets of dietary supplements used for obesity treatment: the specific case of a conjugated linoleic acid mixture (Tonalin). 2012 J. Agric. Food Chem. pmid:23072574
Hu ZP et al. Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model. 2012 J. Proteome Res. pmid:23078235
Celia C et al. Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders. 2012 Biomed Microdevices pmid:21960035
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Regensburger J et al. Fatty acids and vitamins generate singlet oxygen under UVB irradiation. 2012 Exp. Dermatol. pmid:22229443
Stachowska E et al. Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. 2012 Int J Food Sci Nutr pmid:21721848
Cheguru P et al. Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. 2012 Pflugers Arch. pmid:22218833
Mormile R et al. Linoleic acid and colorectal cancer cell growth suppression: is the deregulation of mitochondrial survivin the key factor? 2012 Int J Colorectal Dis pmid:22231621
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
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da Silva Acosta D et al. Fullerene and omega-3 and omega-6 fatty acids on fish brain antioxidant status. 2012 Fish Physiol. Biochem. pmid:22451341
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Zened A et al. In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. 2012 Animal pmid:22436225
Reynolds CM et al. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. 2012 Mol Nutr Food Res pmid:22700321
Ladeira MM et al. Lipids in the diet and the fatty acid profile in beef: a review and recent patents on the topic. 2012 Recent Pat Food Nutr Agric pmid:22702746
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Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Yu T et al. Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. 2012 Pflugers Arch. pmid:22644615
de Sousa Ferreira Soares G et al. Spectroscopic and thermooxidative analysis of organic okra oil and seeds from Abelmoschus esculentus. 2012 ScientificWorldJournal pmid:22645459
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