Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ma C et al. | NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. | 2016 | Nature | pmid:26934227 |
Padayachee T et al. | The Detection of Metabolite-Mediated Gene Module Co-Expression Using Multivariate Linear Models. | 2016 | PLoS ONE | pmid:26918614 |
Hellström F et al. | Association between plasma concentrations of linoleic acid-derived oxylipins and the perceived pain scores in an exploratory study in women with chronic neck pain. | 2016 | BMC Musculoskelet Disord | pmid:26916287 |
Ripoll-Rozada J et al. | Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation. | 2016 | Mol. Microbiol. | pmid:26915347 |
Harris WS et al. | Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study. | 2016 | PLoS ONE | pmid:26881936 |
Puebla C et al. | Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. | 2016 | Biochim. Biophys. Acta | pmid:26869446 |
Yuan H et al. | A network based covariance test for detecting multivariate eQTL in saccharomyces cerevisiae. | 2016 | BMC Syst Biol | pmid:26818242 |
Ito J et al. | A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. | 2016 | Anal Bioanal Chem | pmid:27549797 |
Xie P et al. | Metabonomic Study of Biochemical Changes in Human Hair of Heroin Abusers by Liquid Chromatography Coupled with Ion Trap-Time of Flight Mass Spectrometry. | 2016 | J. Mol. Neurosci. | pmid:26445826 |
Rosenblat M et al. | Nitro-Oleic Acid Reduces J774A.1 Macrophage Oxidative Status and Triglyceride Mass: Involvement of Paraoxonase2 and Triglyceride Metabolizing Enzymes. | 2016 | Lipids | pmid:27344666 |
Abreu P et al. | Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. | 2016 | Exp. Physiol. | pmid:27579497 |
Rodrigues HG et al. | Oral Administration of Linoleic Acid Induces New Vessel Formation and Improves Skin Wound Healing in Diabetic Rats. | 2016 | PLoS ONE | pmid:27764229 |
Kojima K et al. | A simple method for isolation and construction of markerless cyanobacterial mutants defective in acyl-acyl carrier protein synthetase. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27704180 |
Ishida K and Jolly ER | Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion. | 2016 | PLoS Negl Trop Dis | pmid:27611863 |
Venäläinen TM et al. | Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. | 2016 | Am. J. Clin. Nutr. | pmid:27581473 |
Sakayori N et al. | Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring's Anxious Behavior with a Sex-Dependent Manner in Mice. | 2016 | Tohoku J. Exp. Med. | pmid:27558477 |
Karupaiah T et al. | Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design. | 2016 | Lipids Health Dis | pmid:27535127 |
Raimondi S et al. | Conjugated Linoleic Acid Production by Bifidobacteria: Screening, Kinetic, and Composition. | 2016 | Biomed Res Int | pmid:27429985 |
Green D et al. | Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. | 2016 | Mol Pain | pmid:27411353 |
Wang S et al. | Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26879142 |