Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia D007938 74 associated lipids
Coronary Disease D003327 70 associated lipids
Colitis D003092 69 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pain D010146 64 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Thrombosis D013927 49 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Heart Failure D006333 36 associated lipids
Liver Diseases D008107 31 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Birth Weight D001724 23 associated lipids
Helicobacter Infections D016481 21 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Tuberculosis D014376 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Olfaction Disorders D000857 17 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Alopecia D000505 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Liang S et al. Physicochemical Properties and Fatty Acid Profiles of Elaeagnus mollis Diels Nut Oils. 2015 J Oleo Sci pmid:26632946
Qian Z et al. Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice. 2015 Sci Rep pmid:26615818
Fu X et al. Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. 2015 Sci Rep pmid:26567525
Guyenet SJ and Carlson SE Increase in adipose tissue linoleic acid of US adults in the last half century. 2015 Adv Nutr pmid:26567191
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Mansour AB et al. Effect of agricultural sites on differentiation between Chemlali and Neb Jmel olive oils. 2015 J Oleo Sci pmid:25833451
Alnaseri H et al. Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids. 2015 J. Bacteriol. pmid:25802299
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Running CA and Mattes RD Humans are more sensitive to the taste of linoleic and α-linolenic than oleic acid. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:25540234
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Pickens CA et al. Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25559239
Perumalsamy H et al. Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. 2015 Parasit Vectors pmid:25928224
Pruzanski W et al. Diverse activity of human secretory phospholipases A2 on the migration of human vascular smooth muscle cells. 2015 Inflamm. Res. pmid:25999087
Nakahashi H et al. Evaluation of the Key Odorants in Volatile Oils from Tubers of Apios americana Medikus. 2015 J Oleo Sci pmid:26521814
Naughton SS et al. Australia's nutrition transition 1961-2009: a focus on fats. 2015 Br. J. Nutr. pmid:26123446
Salazar MO et al. A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. 2014 Mar-Apr Phytochem Anal pmid:24185747
Song E et al. Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice. 2014 J Am Heart Assoc pmid:24721803
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Hodson L et al. Plasma and erythrocyte fatty acids reflect intakes of saturated and n-6 PUFA within a similar time frame. 2014 J. Nutr. pmid:24225449
Corrêa RC et al. Antioxidant and rheological properties of guava jam with added concentrated grape juice. 2014 J. Sci. Food Agric. pmid:23696312
Tang KS Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. 2014 Lipids Health Dis pmid:25522984
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Yang B et al. Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. 2014 J. Appl. Microbiol. pmid:24750362
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Wright CR and Setzer WN Chemical composition of volatiles from Opuntia littoralis, Opuntia ficus-indica, and Opuntia prolifera growing on Catalina Island, California. 2014 Nat. Prod. Res. pmid:24354326
Radice M et al. Chemical characterization and antioxidant activity of Amazonian (Ecuador) Caryodendron orinocense Karst. and Bactris gasipaes Kunth seed oils. 2014 J Oleo Sci pmid:25391685
Dal Bosco A et al. Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. 2014 Meat Sci. pmid:24036258
Huang FC et al. Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. 2014 Appl. Environ. Microbiol. pmid:24242247
Bonferoni MC et al. Ionic polymeric micelles based on chitosan and fatty acids and intended for wound healing. Comparison of linoleic and oleic acid. 2014 Eur J Pharm Biopharm pmid:24384070
Öztürk M et al. The fatty acid compositions of several plant seed oils belong to Leguminosae and Umbelliferae families. 2014 Environ Monit Assess pmid:24357269
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Darling RA et al. Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24760994