Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Aveldaño MI and Donnari D | Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy. | 1996 | Clin. Chem. | pmid:8598113 |
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Louheranta AM et al. | Linoleic acid intake and susceptibility of very-low-density and low density lipoproteins to oxidation in men. | 1996 | Am. J. Clin. Nutr. | pmid:8615351 |
van Egmond AW et al. | Effect of linoleic acid intake on growth of infants with cystic fibrosis. | 1996 | Am. J. Clin. Nutr. | pmid:8615359 |
DeMar JC et al. | Biosynthesis of the unsaturated 14-carbon fatty acids found on the N termini of photoreceptor-specific proteins. | 1996 | J. Biol. Chem. | pmid:8617777 |
Sidransky H and Verney E | Toxic effect of valproic acid on tryptophan binding to rat hepatic nuclei. | 1996 | Toxicology | pmid:8619251 |
De Luca C et al. | Lipoperoxidase activity of Pityrosporum: characterisation of by-products and possible rôle in pityriasis versicolor. | 1996 | Exp. Dermatol. | pmid:8624612 |
Iwase H et al. | Monoepoxide production from linoleic acid by cytochrome c in the presence of cardiolipin. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630079 |
Hussey HJ et al. | Novel anti-tumour activity of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4- benzoquinone (CV-6504) against established murine adenocarcinomas (MAC). | 1996 | Br. J. Cancer | pmid:8630277 |
Fischer SM et al. | Arachidonate has protumor-promoting action that is inhibited by linoleate in mouse skin carcinogenesis. | 1996 | J. Nutr. | pmid:8642440 |
Ramasamy S et al. | Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. | 1996 | Atherosclerosis | pmid:8645361 |
Cleland LG et al. | Dietary (n-9) eicosatrienoic acid from a cultured fungus inhibits leukotriene B4 synthesis in rats and the effect is modified by dietary linoleic acid. | 1996 | J. Nutr. | pmid:8648425 |
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Watkins BA et al. | Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. | 1996 | Proc. Soc. Exp. Biol. Med. | pmid:8650253 |
Süttmann U et al. | Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support. | 1996 | J Am Diet Assoc | pmid:8655902 |
Loftin CD and Eling TE | Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. | 1996 | Arch. Biochem. Biophys. | pmid:8660674 |
Chen ZY et al. | Accumulation of polyunsaturates is decreased by weight-cycling: whole-body analysis in young, growing rats. | 1996 | Br. J. Nutr. | pmid:8672410 |
van Greevenbroek MM et al. | Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. | 1996 | Atherosclerosis | pmid:8678919 |
Jones GD et al. | Role of lipid hydroperoxides in the activation of 15-lipoxygenase. | 1996 | Biochemistry | pmid:8679548 |
Rodakiewicz-Nowak J et al. | The effect of linoleic acid on pH inside sodium bis(2-ethylhexyl)sulfosuccinate reverse micelles in isooctane and on the enzymic activity of soybean lipoxygenase. | 1996 | Eur. J. Biochem. | pmid:8681970 |
Carnielli VP et al. | Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. | 1996 | Am. J. Clin. Nutr. | pmid:8694014 |
Innis SM and Hansen JW | Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. | 1996 | Am. J. Clin. Nutr. | pmid:8694015 |
Surette ME et al. | Relationship between arachidonate--phospholipid remodeling and apoptosis. | 1996 | Biochemistry | pmid:8703924 |
Ritskes-Hoitinga J et al. | Effects of two dietary fat levels and four dietary linoleic acid levels on mammary tumor development in Balb/c-MMTV mice under ad libitum feeding conditions. | 1996 | Nutr Cancer | pmid:8710685 |
Akeo K et al. | Effects of superoxide dismutase and catalase on growth of retinal pigment epithelial cells in vitro following addition of linoleic acid or linoleic acid hydroperoxide. | 1996 | Ophthalmic Res. | pmid:8726672 |
Griffin ME et al. | Non-insulin-dependent diabetes mellitus: dietary monounsaturated fatty acids and low-density lipoprotein composition and function. | 1996 | QJM | pmid:8731565 |
Chaloner C et al. | Effect of oral supplementation with micronutrient antioxidants on trans fatty acid content of lipoproteins in healthy humans. | 1996 | Biochem. Soc. Trans. | pmid:8736849 |
Campbell FM and Dutta-Roy AK | Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta. | 1996 | Biochem. Soc. Trans. | pmid:8736907 |
Jenkins TC et al. | Butylsoyamide increases unsaturation of fatty acids in plasma and milk of lactating dairy cows. | 1996 | J. Dairy Sci. | pmid:8744223 |
Murai A et al. | Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. | 1995 | Br. Poult. Sci. | pmid:8746984 |
Dunham WR et al. | Oleic acid and linoleic acid are the major determinants of changes in keratinocyte plasma membrane viscosity. | 1996 | J. Invest. Dermatol. | pmid:8751966 |
Moghaddam M et al. | Novel metabolic pathways for linoleic and arachidonic acid metabolism. | 1996 | Biochim. Biophys. Acta | pmid:8765137 |
Hrboticky N et al. | Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. | 1996 | Biochim. Biophys. Acta | pmid:8765140 |
Wiesner R et al. | Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species. | 1996 | FEBS Lett. | pmid:8766705 |
Aoshima H | Potentiation and inhibition of ionotropic neurotransmitter receptors expressed in Xenopus oocyte by linoleic acid and its hydroperoxide. | 1996 | J. Neurochem. | pmid:8769897 |
Connolly JM et al. | Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. | 1996 | Nutr Cancer | pmid:8771566 |
Fellner V et al. | Steady-state rates of linoleic acid biohydrogenation by ruminal bacteria in continuous culture. | 1995 | J. Dairy Sci. | pmid:8786265 |
Ain Baziz H et al. | Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses. | 1996 | Poult. Sci. | pmid:8786940 |
Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
Porkkala-Sarataho E et al. | Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. | 1996 | Atherosclerosis | pmid:8800496 |
Yamada Y et al. | Production of hydroxy fatty acid (10-hydroxy-12(Z)-octadecenoic acid) by Lactobacillus plantarum from linoleic acid and its cardiac effects to guinea pig papillary muscles. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806645 |
Hörnsten L et al. | Dexamethasone induces bisallylic hydroxylation of polyunsaturated fatty acids by rat liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8806734 |
Mizushina Y et al. | Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. | 1996 | Biochim. Biophys. Acta | pmid:8809118 |
Kaneko T et al. | Cytotoxicity of phosphatidylcholine hydroperoxides is exerted through decomposition of fatty acid hydroperoxide moiety. | 1996 | Free Radic. Biol. Med. | pmid:8818632 |
Toborek M et al. | Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells. | 1996 | J. Lipid Res. | pmid:8820108 |
Hatch GM and McClarty G | Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. | 1996 | J. Biol. Chem. | pmid:8824210 |
Engberg RM et al. | Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. | 1996 | Poult. Sci. | pmid:8829233 |
Boyd NF et al. | Long-term effects of participation in a randomized trial of a low-fat, high-carbohydrate diet. | 1996 | Cancer Epidemiol. Biomarkers Prev. | pmid:8833622 |
Glickman MH and Klinman JP | Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. | 1996 | Biochemistry | pmid:8841132 |
Venuta A et al. | Essential fatty acids: the effects of dietary supplementation among children with recurrent respiratory infections. | 1996 Jul-Aug | J. Int. Med. Res. | pmid:8854285 |
Hudson JA et al. | Hydration of oleic acid by a Selenomonas strain from the ovine rumen. | 1996 | Lett. Appl. Microbiol. | pmid:8862016 |
Schurz HH et al. | Products of aniline and triglycerides in oil samples associated with the toxic oil syndrome. | 1996 | Chem. Res. Toxicol. | pmid:8870988 |
Schingoethe DJ et al. | Lactational responses of dairy cows fed unsaturated fat from extruded soybeans or sunflower seeds. | 1996 | J. Dairy Sci. | pmid:8872718 |
Belury MA et al. | Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. | 1996 | Nutr Cancer | pmid:8875552 |
Godessart N et al. | Prostaglandin H-synthase-2 is the main enzyme involved in the biosynthesis of octadecanoids from linoleic acid in human dermal fibroblasts stimulated with interleukin-1beta. | 1996 | J. Invest. Dermatol. | pmid:8875957 |
Lammoglia MA et al. | Effects of dietary fat and season on steroid hormonal profiles before parturition and on hormonal, cholesterol, triglycerides, follicular patterns, and postpartum reproduction in Brahman cows. | 1996 | J. Anim. Sci. | pmid:8880430 |
Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |
Eder K and Kirchgessner M | Zinc deficiency and the desaturation of linoleic acid in rats force-fed fat-free diets. | 1996 | Biol Trace Elem Res | pmid:8886317 |
Peet M et al. | Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888126 |
Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
Avery SV et al. | Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma membrane fatty acid composition. | 1996 | Appl. Environ. Microbiol. | pmid:8899983 |
Cunnane SC | The Canadian Society for Nutritional Sciences 1995 Young Scientist Award Lecture. Recent studies on the synthesis, beta-oxidation, and deficiency of linoleate and alpha-linolenate: are essential fatty acids more aptly named indispensable or conditionally dispensable fatty acids? | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909772 |
Cunnane SC and Likhodii SS | 13C NMR spectroscopy and gas chromatograph--combustion--isotope ratio mass spectrometry: complementary applications in monitoring the metabolism of 13C-labelled polyunsaturated fatty acids. | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909789 |
Godley PA et al. | Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. | 1996 | Cancer Epidemiol. Biomarkers Prev. | pmid:8922296 |
Mensink R | Essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925181 |
Mutanen M and Freese R | Polyunsaturated fatty acids and platelet aggregation. | 1996 | Curr. Opin. Lipidol. | pmid:8925182 |
Sugano M and Ikeda I | Metabolic interactions between essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925188 |
Ranganath LR et al. | Increased mean platelet volume after oestrogen replacement therapy. | 1996 | Ann. Clin. Biochem. | pmid:8937589 |
Shen J et al. | Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development. | 1996 | J. Clin. Invest. | pmid:8941635 |
Matsuo N et al. | Effects of gamma-linolenic acid and its positional isomer pinolenic acid on immune parameters of brown-Norway rats. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951990 |
Applegate TJ and Sell JL | Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. | 1996 | Poult. Sci. | pmid:8966177 |
Mustad VA et al. | Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs. | 1996 | J. Lipid Res. | pmid:8978483 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Hulea SA et al. | Bilirubin sensitized photooxidation of human plasma low density lipoprotein. | 1996 | Biochim. Biophys. Acta | pmid:8982266 |
Tsukamoto S et al. | Effects of bezafibrate on ethanol oxidation in rats. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8986210 |
Kinter M et al. | Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity. | 1996 | J. Nutr. | pmid:9001361 |
Kubin A et al. | Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin. | 1996 | J. Photochem. Photobiol. B, Biol. | pmid:9002246 |
Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
Staprans I et al. | Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. | 1996 | J. Lipid Res. | pmid:9026539 |
Hayashi T et al. | Stimulation of cell proliferation and inhibition of gap junctional intercellular communication by linoleic acid. | 1997 | Cancer Lett. | pmid:9029175 |
Cogo PE et al. | Simultaneous measurement of the rates of appearance of palmitic and linoleic acid in critically ill infants. | 1997 | Pediatr. Res. | pmid:9029635 |
Brun T et al. | Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. | 1997 | Diabetes | pmid:9032094 |
Black PN and Sharpe S | Dietary fat and asthma: is there a connection? | 1997 | Eur. Respir. J. | pmid:9032484 |
Solà R et al. | Oleic acid rich diet protects against the oxidative modification of high density lipoprotein. | 1997 | Free Radic. Biol. Med. | pmid:9034243 |
Chen ZY et al. | Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. | 1997 | Am. J. Physiol. | pmid:9038989 |
Gargouri M and Legoy MD | The kinetic behaviour of a two-enzyme system in biphasic media: coupling hydrolysis and lipoxygenation. | 1997 | Biochim. Biophys. Acta | pmid:9048899 |
Das I et al. | Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. | 1997 | Biochem. Soc. Trans. | pmid:9056997 |
Kühn H et al. | In vivo action of 15-lipoxygenase in early stages of human atherogenesis. | 1997 | J. Clin. Invest. | pmid:9062346 |
Roy SK and Kulkarni AP | Isolation and some properties of dioxygenase and co-oxidase activities of adult human liver cytosolic lipoxygenase. | 1996 | J. Biochem. Toxicol. | pmid:9062846 |
Patel RP et al. | Reduction of Cu(II) by lipid hydroperoxides: implications for the copper-dependent oxidation of low-density lipoprotein. | 1997 | Biochem. J. | pmid:9065759 |
Butler M et al. | Unsaturated fatty acids enhance cell yields and perturb the energy metabolism of an antibody-secreting hybridoma. | 1997 | Biochem. J. | pmid:9065785 |
Reddy N et al. | Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070230 |
Iwase H et al. | Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070266 |