Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Oh-hashi K et al. | Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9524928 |
Jiang WG et al. | Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514943 |
Böhmer S et al. | Oxidation of phenanthrene by a fungal laccase in the presence of 1-hydroxybenzotriazole and unsaturated lipids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514895 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Jiang WG et al. | The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells. | 1998 | Br. J. Cancer | pmid:9514051 |
Freyaldenhoven MA et al. | Retinoic acid-dependent stimulation of 2,2'-azobis(2-amidinopropane)-initiated autoxidation of linoleic acid in sodium dodecyl sulfate micelles: a novel prooxidant effect of retinoic acid. | 1998 | Chem. Res. Toxicol. | pmid:9511901 |
Dänicke S et al. | Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. | 1997 | Br. Poult. Sci. | pmid:9511000 |
Saha SK et al. | Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. | 1997 | Jpn. J. Physiol. | pmid:9504135 |
Yehuda S et al. | Fatty acids and brain peptides. | 1998 | Peptides | pmid:9493877 |
Bremmer DR et al. | Effects of chain length and unsaturation of fatty acid mixtures infused into the abomasum of lactating dairy cows. | 1998 | J. Dairy Sci. | pmid:9493093 |