Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Guo J et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. 2013 Animal pmid:23031491
Men XM et al. Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs. 2013 Animal pmid:23764195
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Yen CH et al. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. 2008 Ann. Allergy Asthma Immunol. pmid:18254485
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Taylor AJ Erythrocyte membrane fatty acid composition in hypercholesterolaemia. 1994 Ann. Clin. Biochem. pmid:7979101
Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
Davis PA et al. A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. 1993 Ann. Intern. Med. pmid:8363165
Kankaanpää P et al. Dietary fatty acids and allergy. 1999 Ann. Med. pmid:10480759
Chopra M et al. Free radical scavenging of lutein in vitro. 1993 Ann. N. Y. Acad. Sci. pmid:8129303
Thompson RL et al. Cigarette smoking, polyunsaturated fats, and coronary heart disease. 1993 Ann. N. Y. Acad. Sci. pmid:8512244
Sugano M and Koba K Dietary protein and lipid metabolism: a multifunctional effect. 1993 Ann. N. Y. Acad. Sci. pmid:8489133
Merendino N et al. Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. 2003 Ann. N. Y. Acad. Sci. pmid:15033753
Schlame M et al. Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. 2002 Ann. Neurol. pmid:12112112
Sakai T et al. Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. 1991 Ann. Neurol. pmid:1832532
Charnock JS et al. Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. 1985 Ann. Nutr. Metab. pmid:3922279
Babin F et al. Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts. 1988 Ann. Nutr. Metab. pmid:3195990
Carreau JP et al. Cholesterol synthesis in the liver, kidneys and brain after injection of uniformly 14C-labeled oleic or linoleic acid to developing rats. 1982 Ann. Nutr. Metab. pmid:6814348
Romijn D et al. A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. 1998 Ann. Nutr. Metab. pmid:9745111
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Mogenson GJ and Box BM Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. 1982 Ann. Nutr. Metab. pmid:7137945
Adam O et al. Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. 1982 Ann. Nutr. Metab. pmid:7137955
Fuhrmann H and Sallmann HP Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. 1995 Ann. Nutr. Metab. pmid:8585700
Saito M and Yamaguchi M Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. 1994 Ann. Nutr. Metab. pmid:7832581
Saín J et al. Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. 2013 Ann. Nutr. Metab. pmid:23594856
Boissonneault GA et al. Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. 1995 Ann. Nutr. Metab. pmid:7872651
Santos MJ et al. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. 1995 Ann. Nutr. Metab. pmid:7872656
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
Kort WJ et al. Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. 1986 Ann. Nutr. Metab. pmid:3963748
Roshanai F and Sanders TA Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4037727
Fidler N et al. Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. 1999 Ann. Nutr. Metab. pmid:10725767
Charnock JS et al. Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4051450
Adam O Linoleic acid - the fall of an angel? 1999 Ann. Nutr. Metab. pmid:10725772
Charnock JS et al. Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. 1985 Ann. Nutr. Metab. pmid:4051452
Soltysova T and Bellisle F Nutrition in ten-year-old children of the Liberec area (Czech Republic). 1994 Ann. Nutr. Metab. pmid:7979168
Pascaud M and Strouve-Vallet C Desaturation of 14C linoleic acid by the rat fetus. 1985 Ann. Nutr. Metab. pmid:2983600
Roth HP and Kirchgessner M [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. 1992 Ann. Nutr. Metab. pmid:1354951
Aziz AA et al. Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. 2010 Ann. Nutr. Metab. pmid:20714137
Jensen MM et al. Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. 1994 Ann. Nutr. Metab. pmid:8067685
Heine RJ et al. The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. 1984 Ann. Nutr. Metab. pmid:6476785
de Deckere EA et al. Hepatic de novo fatty acid synthesis in the rat. 1993 Ann. Nutr. Metab. pmid:8215236
Katan MB et al. Biological markers of dietary intake, with emphasis on fatty acids. 1991 Ann. Nutr. Metab. pmid:1776820
Xiang M et al. Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. 2006 Ann. Nutr. Metab. pmid:16988497
Decsi T and Koletzko B Do trans fatty acids impair linoleic acid metabolism in children? 1995 Ann. Nutr. Metab. pmid:7872654
De Vriese SR et al. Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. 2001 Ann. Nutr. Metab. pmid:11786650
Black JM and Kinsella JE Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. 1993 Ann. Nutr. Metab. pmid:8373135
Adam O et al. Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. 2003 Ann. Nutr. Metab. pmid:12624485
Leat WM et al. Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. 1986 Ann. Nutr. Metab. pmid:2872851
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461
Jakobsen K et al. Heat production and quantitative oxidation of nutrients by physical activity in pigs. 1994 Ann. Nutr. Metab. pmid:8185282