Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Pal S and Davis PJ N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. 1990 Biochem. Biophys. Res. Commun. pmid:2260969
Blee E et al. Regio- and stereoselectivity of cytochrome P-450 and peroxygenase-dependent formation of cis-12,13-epoxy-9(Z)-octadecenoic acid (vernolic acid) in Euphorbia lagascae. 1993 Biochem. Biophys. Res. Commun. pmid:8267615
Lee CW et al. Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin. 2015 Biochem. Biophys. Res. Commun. pmid:26206084
Garscha U and Oliw E Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase. 2008 Biochem. Biophys. Res. Commun. pmid:18586008
Iwase H et al. Superoxide anion reduces the ability of myeloperoxidase to damage lipids. 1996 Biochem. Biophys. Res. Commun. pmid:8605038
Kotarsky K et al. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. 2003 Biochem. Biophys. Res. Commun. pmid:12565875
Wooten MW and Wrenn RW Linoleic acid is a potent activator of protein kinase C type III-alpha isoform in pancreatic acinar cells; its role in amylase secretion. 1988 Biochem. Biophys. Res. Commun. pmid:2454109
Canfield LM et al. Anti-oxidant/pro-oxidant reactions of vitamin K. 1985 Biochem. Biophys. Res. Commun. pmid:3985964
Byczkowski JZ and Kulkarni AP Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. 1989 Biochem. Biophys. Res. Commun. pmid:2494999
Kapich A et al. Coupling of manganese peroxidase-mediated lipid peroxidation with destruction of nonphenolic lignin model compounds and 14C-labeled lignins. 1999 Biochem. Biophys. Res. Commun. pmid:10334942
Jung KC et al. Determination of the dissociation constants for recombinant c-Myc, Max, and DNA complexes: the inhibitory effect of linoleic acid on the DNA-binding step. 2005 Biochem. Biophys. Res. Commun. pmid:16002048
Sakurada K et al. cis-9,10-Methylenehexadecanoic acid inhibits contractility and actomyosin ATPase activity of guinea pig myocardium. 2000 Biochem. Biophys. Res. Commun. pmid:10913372
Iwase H et al. Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. 1997 Biochem. Biophys. Res. Commun. pmid:9070266
Andrianarison RH et al. Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. 1991 Biochem. Biophys. Res. Commun. pmid:1953704
Whitehouse AS and Tisdale MJ Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. 2001 Biochem. Biophys. Res. Commun. pmid:11453634
Giamalva D et al. A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. 1985 Biochem. Biophys. Res. Commun. pmid:4084297
Schneider C et al. A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase. 1997 Biochem. Biophys. Res. Commun. pmid:9125182
Kambayashi Y et al. Preferential hydrolysis of oxidized phosphatidylcholine in cholesterol-containing phosphatidylcholine liposome by phospholipase A2. 1998 Biochem. Biophys. Res. Commun. pmid:9588178
Rose DP and Connolly JM Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. 1989 Biochem. Biophys. Res. Commun. pmid:2803300
Matsumoto M et al. D-galactosamine-induced cell damage enhances specific binding of prostaglandin E1 to rat hepatocytes. 1992 Biochem. Biophys. Res. Commun. pmid:1315527
Nikolaev V et al. Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. 1990 Biochem. Biophys. Res. Commun. pmid:2116790
Reddy N et al. Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF. 1997 Biochem. Biophys. Res. Commun. pmid:9070230
Iwase H et al. Calcium ions potentiate lipoxygenase activity of cytochrome c at the physiological pH. 1998 Biochem. Biophys. Res. Commun. pmid:9480835
Mullarkey CJ et al. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. 1990 Biochem. Biophys. Res. Commun. pmid:2176495
Chu CH et al. The activity of 3-hydroxyacyl-CoA epimerase is insufficient to account for the rate of linoleate oxidation in rat heart mitochondria. Evidence for a modified pathway of linoleate degradation. 1984 Biochem. Biophys. Res. Commun. pmid:6696754
Tannin-Spitz T et al. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. 2007 Biochem. Biophys. Res. Commun. pmid:17942079
Chen Q et al. Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells. 2011 Biochem. Biophys. Res. Commun. pmid:21679695
Murakami K et al. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. 1999 Biochem. Biophys. Res. Commun. pmid:10403814
Ou L et al. Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. 2007 Biochem. Biophys. Res. Commun. pmid:17400188
Lee JY and Hwang DH Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. 2002 Biochem. Biophys. Res. Commun. pmid:12419306
Kang K et al. Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. 2004 Biochem. Biophys. Res. Commun. pmid:14975733
Breton M et al. Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. 1983 Biochem. Biophys. Res. Commun. pmid:6230079
Chapkin RS and Ziboh VA Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. 1984 Biochem. Biophys. Res. Commun. pmid:6439197
Hori T et al. Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2114113
Verma SP and Wallach DF Action of ionizing radiation on lipid-protein interaction. 1982 Biochem. Biophys. Res. Commun. pmid:6896453
Fávaro RD et al. ZmPUMP encodes a fully functional monocot plant uncoupling mitochondrial protein whose affinity to fatty acid is increased with the introduction of a His pair at the second matrix loop. 2006 Biochem. Biophys. Res. Commun. pmid:16603126
Zhao G et al. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. 2005 Biochem. Biophys. Res. Commun. pmid:16169525
Sharpe M et al. Ligation, inhibition, and activation of cytochrome c oxidase by fatty acids. 1997 Biochem. Cell Biol. pmid:9192076
Stewart JM et al. Comparisons of the effects of temperature on the liver fatty acid binding proteins from hibernator and nonhibernator mammals. 1998 Biochem. Cell Biol. pmid:10099779
Poirier H et al. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. 2001 Biochem. J. pmid:11284737
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. 1963 Biochem. J. pmid:14071526
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. 1963 Biochem. J. pmid:14071527
LEAT WM FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. 1963 Biochem. J. pmid:14097364
Carpenter KL et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. 1994 Biochem. J. pmid:7999000
Swida A et al. Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. 2008 Biochem. J. pmid:18402555
Babizhayev MA et al. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. 1994 Biochem. J. pmid:7998987
Hughes RK et al. Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms. 1998 Biochem. J. pmid:9639559
Arslan P et al. cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. 1984 Biochem. J. pmid:6696740
Rayner BS et al. Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution. 2004 Biochem. J. pmid:15035657
Louet JF et al. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. 2001 Biochem. J. pmid:11171094