Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Bosca F et al. Photophysical and photochemical characterization of a photosensitizing drug: a combined steady state photolysis and laser flash photolysis study on carprofen. 1997 Chem. Res. Toxicol. pmid:9250417
Parmentier HK et al. Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. 1997 Poult. Sci. pmid:9251147
Howlett NG and Avery SV Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. 1997 Appl. Environ. Microbiol. pmid:9251184
Siguel E Essential fatty acid status in patients. 1997 Jul-Aug JPEN J Parenter Enteral Nutr pmid:9252955
Castelli F et al. Dipalmitoylphosphatidylcholine/linoleic acid mixed unilamellar vesicles as model membranes for studies on novel free-radical scavengers. 1997 J Pharmacol Toxicol Methods pmid:9253749
Risé P et al. Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. 1997 J. Lipid Res. pmid:9254057
Bakker N et al. Adipose fatty acids and cancers of the breast, prostate and colon: an ecological study. EURAMIC Study Group. 1997 Int. J. Cancer pmid:9259395
Badart-Smook A et al. Fetal growth is associated positively with maternal intake of riboflavin and negatively with maternal intake of linoleic acid. 1997 J Am Diet Assoc pmid:9259708
Feussner I et al. Structural elucidation of oxygenated storage lipids in cucumber cotyledons. Implication of lipid body lipoxygenase in lipid mobilization during germination. 1997 J. Biol. Chem. pmid:9261186
Jenkins TC Ruminal fermentation and nutrient digestion in sheep fed hydroxyethylsoyamide. 1997 J. Anim. Sci. pmid:9263076
Lopez Jimenez JA et al. Linoleic acid metabolism in primary cultures of adult rat cardiomyocytes is impaired by aging. 1997 Biochem. Biophys. Res. Commun. pmid:9266846
Fabritius D et al. Biotransformation of linoleic acid with the Candida tropicalis M25 mutant. 1997 Appl. Microbiol. Biotechnol. pmid:9274051
Batna A et al. Lipid peroxidation in presence of ebselen. 1997 Chem. Phys. Lipids pmid:9275309
Usha S and Balakrishnan A c-myc, c-H-ras, and IP3 elevation in 18:2 n-6 dependent proliferation of lung cells. 1997 Jul-Aug In Vitro Cell. Dev. Biol. Anim. pmid:9282304
Carlson SE Functional effects of increasing omega-3 fatty acid intake. 1997 J. Pediatr. pmid:9290597
Jensen CL et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. 1997 J. Pediatr. pmid:9290604
López-Nicolás JM et al. Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase. 1997 Biochim. Biophys. Acta pmid:9295158
Hall JA et al. Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. 1997 Jul-Aug J. Vet. Intern. Med. pmid:9298479
de Waart FG et al. Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL. 1997 Atherosclerosis pmid:9298686
Rusnak A et al. Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production. 1997 J. Bioenerg. Biomembr. pmid:9298714