Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Willett WC | Specific fatty acids and risks of breast and prostate cancer: dietary intake. | 1997 | Am. J. Clin. Nutr. | pmid:9394715 |
Ali I and Steele JE | Evidence that free fatty acids in trophocytes of Periplaneta americana fat body may be regulated by the activity of phospholipase A2 and cyclooxygenase. | 1997 | Insect Biochem. Mol. Biol. | pmid:9404012 |
Gniwotta C et al. | Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409317 |
van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
Kritchevsky D | Trans fatty acids and cardiovascular risk. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430386 |
Renaud SC | Dietary management of cardiovascular diseases. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430390 |
Zhou L et al. | Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. | 1997 | Biochim. Biophys. Acta | pmid:9434134 |
Bylund J et al. | Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435160 |
Kaur K et al. | (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins. | 1997 | Chem. Res. Toxicol. | pmid:9437530 |
Berry H et al. | Oxygen concentration determines regiospecificity in soybean lipoxygenase-1 reaction via a branched kinetic scheme. | 1998 | J. Biol. Chem. | pmid:9446584 |
Hamberg M | Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. | 1998 | Arch. Biochem. Biophys. | pmid:9448728 |
Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
Maheswari SU et al. | Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin. | 1997 | Mol. Cell. Biochem. | pmid:9450644 |
van Roermund CW et al. | Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions. | 1998 | EMBO J. | pmid:9450993 |
Dadras SS et al. | Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. | 1998 | Int. J. Oncol. | pmid:9454884 |
Devor DC and Frizzell RA | Modulation of K+ channels by arachidonic acid in T84 cells. II. Activation of a Ca(2+)-independent K+ channel. | 1998 | Am. J. Physiol. | pmid:9458723 |
Herbel BK et al. | Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9459383 |
Pomposiello SI et al. | Linoleic acid induces relaxation and hyperpolarization of the pig coronary artery. | 1998 | Hypertension | pmid:9461230 |
Bouwstra JA et al. | Role of ceramide 1 in the molecular organization of the stratum corneum lipids. | 1998 | J. Lipid Res. | pmid:9469597 |
Iwase H et al. | Calcium ions potentiate lipoxygenase activity of cytochrome c at the physiological pH. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9480835 |