Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sébédio JL et al. | Recent advances in conjugated linoleic acid research. | 1999 | Curr Opin Clin Nutr Metab Care | pmid:10678680 |
Rüttinger HH and Radschuweit A | Determination of peroxides by capillary zone electrophoresis with amperometric detection. | 2000 | J Chromatogr A | pmid:10677087 |
Jarmuszkiewicz W et al. | First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosis. | 2000 | FEBS Lett. | pmid:10675527 |
Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
Grobas S et al. | Influence of dietary energy, supplemental fat and linoleic acid concentration on performance of laying hens at two ages. | 1999 | Br. Poult. Sci. | pmid:10670682 |
Heeley EL et al. | Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666114 |
Rukkwamsuk T et al. | Interrelation of fatty acid composition in adipose tissue, serum, and liver of dairy cows during the development of fatty liver postpartum. | 2000 | J. Dairy Sci. | pmid:10659963 |
Berghaus TM et al. | Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation. | 2000 | Biol. Neonate | pmid:10657686 |
de Deckere EA et al. | Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. | 1999 | Br. J. Nutr. | pmid:10655980 |
Oriani G et al. | Effects of intramuscular injection of alpha-tocopheryl acetate on fatty acid profile in lamb liver. | 1999 | Int J Vitam Nutr Res | pmid:10642895 |
Salo P et al. | Low-saturated fat, low-cholesterol diet in 3-year-old children: effect on intake and composition of trans fatty acids and other fatty acids in serum phospholipid fraction-The STRIP study. Special Turku coronary Risk factor Intervention Project for children. | 2000 | J. Pediatr. | pmid:10636973 |
Connolly JM et al. | Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. | 1999 | Nutr Cancer | pmid:10624705 |
Horrobin DF | Essential fatty acid metabolism and its modification in atopic eczema. | 2000 | Am. J. Clin. Nutr. | pmid:10617999 |
Ziboh VA et al. | Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. | 2000 | Am. J. Clin. Nutr. | pmid:10617998 |
Dutta-Roy AK | Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. | 2000 | Am. J. Clin. Nutr. | pmid:10617989 |
Crawford M | Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617983 |
Gibson RA and Makrides M | n-3 polyunsaturated fatty acid requirements of term infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617980 |
Uauy R and Hoffman DR | Essential fat requirements of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617979 |
Sanders TA | Polyunsaturated fatty acids in the food chain in Europe. | 2000 | Am. J. Clin. Nutr. | pmid:10617968 |
Meerarani P et al. | Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. | 2000 | Am. J. Clin. Nutr. | pmid:10617950 |