Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Malkowski MG et al. | Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. | 2001 | J. Biol. Chem. | pmid:11477109 |
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Gupta SV and Khosla P | Palmitic and stearic acids similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. | 2001 | J. Nutr. | pmid:11481404 |
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Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
Sewram V et al. | Supercritical fluid extraction and analysis of compounds from Clivia miniata for uterotonic activity. | 2001 | Planta Med. | pmid:11488461 |
Chen ZY et al. | Accumulation and apparent oxidation of cis,trans-18 : 2 isomers relative to linoleic acid in rats. | 2001 | Br. J. Nutr. | pmid:11502239 |
Chang W et al. | Induction of cardiac FABP gene expression by long chain fatty acids in cultured rat muscle cells. | 2001 | Mol. Cell. Biochem. | pmid:11506175 |
Févrie P et al. | Separation of glyceride positional isomers by silver ion chromatography. | 2001 | J Chromatogr A | pmid:11510559 |
Prescha A et al. | Increase in lipid content in potato tubers modified by 14-3-3 gene overexpression. | 2001 | J. Agric. Food Chem. | pmid:11513640 |
Lin Y et al. | Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. | 2001 | Biochim. Biophys. Acta | pmid:11514234 |
Pérez-Pé R et al. | Semen plasma proteins prevent cold-shock membrane damage to ram spermatozoa. | 2001 | Theriogenology | pmid:11516122 |
Ramsay TG et al. | Dietary conjugated linoleic acid alters fatty acid composition of pig skeletal muscle and fat. | 2001 | J. Anim. Sci. | pmid:11518224 |
Wiegand BR et al. | Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves certain aspects of meat quality in stress-genotype pigs. | 2001 | J. Anim. Sci. | pmid:11518228 |
Kucuk O et al. | Effect of forage:concentrate ratio on ruminal digestion and duodenal flow of fatty acids in ewes. | 2001 | J. Anim. Sci. | pmid:11518234 |
Abu-Ghazaleh AA et al. | Conjugated linoleic acid and other beneficial fatty acids in milk fat from cows fed soybean meal, fish meal, or both. | 2001 | J. Dairy Sci. | pmid:11518309 |
Cubillos MA et al. | Kinetics of peroxidation of linoleic acid incorporated into DPPC vesicles initiated by the thermal decomposition of 2,2'-azobis(2-amidinopropane) dihydrochloride. | 2001 | Chem. Phys. Lipids | pmid:11518571 |
Olsson U et al. | Changes in matrix proteoglycans induced by insulin and fatty acids in hepatic cells may contribute to dyslipidemia of insulin resistance. | 2001 | Diabetes | pmid:11522680 |
Aro A et al. | Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. | 2000 | Nutr Cancer | pmid:11525591 |
Brown JM et al. | Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. | 2001 | J. Nutr. | pmid:11533273 |
Bassaganya-Riera J et al. | Dietary conjugated linoleic acid modulates phenotype and effector functions of porcine CD8(+) lymphocytes. | 2001 | J. Nutr. | pmid:11533281 |
McKay MC and Worley JF | Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546665 |
Kang K and Pariza MW | trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554738 |
Borecký J et al. | Functional reconstitution of Arabidopsis thaliana plant uncoupling mitochondrial protein (AtPUMP1) expressed in Escherichia coli. | 2001 | FEBS Lett. | pmid:11566183 |
Gurvitz A et al. | Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. | 2001 | Biochim. Biophys. Acta | pmid:11566445 |
Rainio A et al. | Reduction of linoleic acid inhibition in production of conjugated linoleic acid by Propionibacterium freudenreichii ssp. shermanii. | 2001 | Can. J. Microbiol. | pmid:11575500 |
Kelly GS | Conjugated linoleic acid: a review. | 2001 | Altern Med Rev | pmid:11578253 |
Poulos SP et al. | Pre- and postnatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague-Dawley rats. | 2001 | J. Nutr. | pmid:11584096 |
Costarelli V and Sanders TA | Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women. | 2001 | Br. J. Nutr. | pmid:11591234 |
Berthoud HR et al. | Food-related gastrointestinal signals activate caudal brainstem neurons expressing both NMDA and AMPA receptors. | 2001 | Brain Res. | pmid:11595203 |
Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
Ruiz-Sanz JI et al. | Polyunsaturated fatty acid deficiency during dietary treatment of very long-chain acyl-CoA dehydrogenase deficiency. Rescue with soybean oil. | 2001 | J. Inherit. Metab. Dis. | pmid:11596652 |
Goffman FD and Böhme T | Relationship between fatty acid profile and vitamin E content in maize hybrids (Zea mays L.). | 2001 | J. Agric. Food Chem. | pmid:11600056 |
Haastrup A et al. | Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. | 2001 | Hypertension | pmid:11641299 |
Kozachenko AI et al. | Characteristics of beta-carotene-induced inhibition of free radical oxidation of fatty acids with different degree of unsaturation. | 2001 Jul-Aug | Dokl. Biochem. Biophys. | pmid:11665681 |
Kolesnichenko AV et al. | Influence of CSP 310 and CSP 310-like proteins from cereals on mitochondrial energetic activity and lipid peroxidation in vitro and in vivo. | 2001 | BMC Plant Biol. | pmid:11667950 |
Rahamatalla AB et al. | Changes in fatty acids composition during seed growth and physicochemical characteristics of oil extracted from four safflower cultivars. | 2001 | Plant Foods Hum Nutr | pmid:11678443 |
Djoussé L et al. | Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. | 2001 | Am. J. Clin. Nutr. | pmid:11684529 |
López Bote CJ et al. | Effect of dietary linoleic acid concentration and vitamin E supplementation on cell desquamation and susceptibility to oxidative damage of pig jejunal mucosa. | 2001 | J Anim Physiol Anim Nutr (Berl) | pmid:11686769 |
Aleynik MK and Lieber CS | Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11689017 |
Finley JW and Davis CD | Manganese absorption and retention in rats is affected by the type of dietary fat. | 2001 | Biol Trace Elem Res | pmid:11697763 |
Kelavkar UP et al. | Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis. | 2001 | Carcinogenesis | pmid:11698337 |
Ramaswamy N et al. | Composition and flavor of milk and butter from cows fed fish oil, extruded soybeans, or their combination. | 2001 | J. Dairy Sci. | pmid:11699444 |
Hagenlocher T et al. | Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers: a pilot study. | 2001 | Cancer Epidemiol. Biomarkers Prev. | pmid:11700267 |
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Cigliano L et al. | Estradiol esterification in the human preovulatory follicle. | 2001 | Steroids | pmid:11711117 |
Strandvik B et al. | Essential fatty acid deficiency in relation to genotype in patients with cystic fibrosis. | 2001 | J. Pediatr. | pmid:11713441 |
Moran JH et al. | Linoleic acid prevents chloride influx and cellular lysis in rabbit renal proximal tubules exposed to mitochondrial toxicants. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11714247 |
Calaf RE et al. | Automated strong cation exchange extraction of fatty acid esters of 3-(N-phenylamino)-1,2-propanediol from oil samples for routine quantification by HPLC-APCI/MS/MS. | 2001 | J. Agric. Food Chem. | pmid:11714286 |
Palinski W et al. | Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits. | 2001 | Circ. Res. | pmid:11717155 |
Milani G et al. | Respiratory chain network in mitochondria of Candida parapsilosis: ADP/O appraisal of the multiple electron pathways. | 2001 | FEBS Lett. | pmid:11718721 |
Weber TE et al. | Evaluation of conjugated linoleic acid and dietary antibiotics as growth promotants in weanling pigs. | 2001 | J. Anim. Sci. | pmid:11721832 |
Thom E et al. | Conjugated linoleic acid reduces body fat in healthy exercising humans. | 2001 Sep-Oct | J. Int. Med. Res. | pmid:11725826 |
Glew RH et al. | Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728165 |
Villalpando S et al. | [13C]linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes. | 2001 | Am. J. Clin. Nutr. | pmid:11729835 |
Park Y and Pariza MW | The effects of dietary conjugated nonadecadienoic acid on body composition in mice. | 2001 | Biochim. Biophys. Acta | pmid:11731328 |
Peters JM et al. | Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. | 2001 | Biochim. Biophys. Acta | pmid:11731333 |
Lee BD et al. | Nutritive and economic values of high oil corn in layer diet. | 2001 | Poult. Sci. | pmid:11732667 |
Watanabe T et al. | Production and chemiluminescent free radical reactions of glyoxal in lipid peroxidation of linoleic acid by the ligninolytic enzyme, manganese peroxidase. | 2001 | Eur. J. Biochem. | pmid:11733005 |
Gustafsson MC et al. | Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species. | 2001 | Arch. Microbiol. | pmid:11734890 |
Pelikánová T et al. | Serum phospholipid fatty acid composition and insulin action in type 2 diabetic patients. | 2001 | Metab. Clin. Exp. | pmid:11735096 |
Fernández-Real JM et al. | Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. | 2001 | Metab. Clin. Exp. | pmid:11735097 |
Büyükokuroğlu ME et al. | In vitro antioxidant properties of dantrolene sodium. | 2001 | Pharmacol. Res. | pmid:11735355 |
Melamed-Frank M et al. | Structure-function analysis of the antioxidant properties of haptoglobin. | 2001 | Blood | pmid:11739174 |
Coles B et al. | Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP. | 2002 | J. Biol. Chem. | pmid:11748216 |
Pirtle IL et al. | Molecular cloning and functional expression of the gene for a cotton Delta-12 fatty acid desaturase (FAD2). | 2001 | Biochim. Biophys. Acta | pmid:11750064 |
Smith WG et al. | Lipoprotein susceptibility to oxidation in the macromolecular fraction of plasma: relation to plasma lipids and oleate/linoleate ratio in comparison with whole plasma in hypertriglyceridemia. | 2002 | Clin. Chim. Acta | pmid:11750269 |
Smith WG et al. | Simple and rapid assessment of lipoprotein susceptibility to oxidation in the macromolecule fraction of plasma. | 2002 | Clin. Chim. Acta | pmid:11750270 |
Park Y and Pariza MW | Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. | 2001 | Biochim. Biophys. Acta | pmid:11750884 |
Larqué E et al. | Dietary trans fatty acids in early life: a review. | 2001 | Early Hum. Dev. | pmid:11755033 |
Mottaran E et al. | Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. | 2002 | Free Radic. Biol. Med. | pmid:11755315 |
Ohnuki K et al. | Increased energy metabolism and suppressed body fat accumulation in mice by a low concentration of conjugated linoleic acid. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11758910 |
Ip C et al. | Control of rat mammary epithelium proliferation by conjugated linoleic acid. | 2001 | Nutr Cancer | pmid:11759286 |
Yang H et al. | Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione. | 2001 | Nutr Cancer | pmid:11759290 |
Radschuweit A et al. | Capillary zone electrophoresis with electrochemical detection--a simple and effective method to analyze oxygen-consuming and peroxide-forming processes. | 2001 | J Chromatogr A | pmid:11765078 |
Eggert JM et al. | Effects of conjugated linoleic acid on the belly firmness and fatty acid composition of genetically lean pigs. | 2001 | J. Anim. Sci. | pmid:11768116 |
Olson RE | The key to an enigma: how do dietary polyunsaturated fatty acids lower serum cholesterol? | 2002 | J. Nutr. | pmid:11773520 |
Tripathi AK et al. | A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779214 |
Birnbaum L | Addition of conjugated linoleic acid to a herbal anticellulite pill. | 2001 Sep-Oct | Adv Ther | pmid:11783459 |
De Vriese SR et al. | Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. | 2001 | Ann. Nutr. Metab. | pmid:11786650 |
Gwak HS and Chun IK | Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins. | 2001 | Arch. Pharm. Res. | pmid:11794538 |
Vargas F et al. | In vitro antioxidant and photo-oxidant properties of dipyridamole. | 2001 Nov-Dec | Int. J. Toxicol. | pmid:11797818 |
Kawajiri H et al. | Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. | 2002 | Arch. Biochem. Biophys. | pmid:11811948 |
Mitchell LA et al. | Linoleic acid, cis-epoxyoctadecenoic acids, and dihydroxyoctadecadienoic acids are toxic to Sf-21 cells in the absence of albumin. | 2002 | Toxicol. Lett. | pmid:11814707 |