Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cho H et al. | Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. | 2003 | Anal. Biochem. | pmid:12782030 |
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pmid:12790685 | ||||
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Politis I et al. | Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. | 2003 | Br. Poult. Sci. | pmid:12828205 |
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Salvatori G et al. | Control of dietary energy level and dl-alpha-tocopheryl acetate treatment can improve the lipid composition of lamb meat. | 2003 | Int J Vitam Nutr Res | pmid:12847993 |
Kim YJ | Partial inhibition of biohydrogenation of linoleic acid can increase the conjugated linoleic acid production of Butyrivibrio fibrisolvens A38. | 2003 | J. Agric. Food Chem. | pmid:12848494 |
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Yamasaki M et al. | Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid. | 2003 | Cancer Lett. | pmid:12860277 |
Nguyen SD and Sok DE | Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. | 2003 | Biochem. J. | pmid:12871208 |
Kilian M et al. | Influence of conjugated and conventional linoleic acid on tumor growth and lipid peroxidation in pancreatic adenocarcinoma in hamster. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878453 |
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Gollnick H | Current concepts of the pathogenesis of acne: implications for drug treatment. | 2003 | Drugs | pmid:12887264 |
Kim EJ et al. | Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. | 2003 | J. Nutr. | pmid:12888657 |
Lee SO et al. | Bioconversion of linoleic acid into conjugated linoleic acid during fermentation and by washed cells of Lactobacillus reuteri. | 2003 | Biotechnol. Lett. | pmid:12889826 |
Torres CF et al. | Lipase-catalyzed esterification of conjugated linoleic acid with sorbitol: a kinetic study. | 2003 Jul-Aug | Biotechnol. Prog. | pmid:12892488 |
Miyazawa D et al. | Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. | 2003 | Life Sci. | pmid:12899931 |
Thibault C et al. | Effect of feeding prepubertal heifers with a high oil diet on mammary development and milk production. | 2003 | J. Dairy Sci. | pmid:12906048 |
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Hiramoto K et al. | Suppression of free radical-induced DNA strand breaks by linoleic acid and low density lipoprotein in vitro. | 2003 | Biol. Pharm. Bull. | pmid:12913264 |
Kim KH and Park HS | Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers. | 2003 | Nutrition | pmid:12921888 |
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Kelsey JA et al. | The effect of breed, parity, and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows. | 2003 | J. Dairy Sci. | pmid:12939083 |
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Pilitsis JG et al. | Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. | 2003 | Neurosci. Lett. | pmid:12946571 |
Bull AW et al. | Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma. | 2003 | Carcinogenesis | pmid:12949056 |
Yang L et al. | Isomeric distribution of conjugated linoleic acids (CLA) in the tissues of layer hens fed a CLA diet. | 2003 | J. Agric. Food Chem. | pmid:12952415 |
Seibold SA et al. | Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases. | 2003 | J. Biol. Chem. | pmid:12952981 |
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Ogborn MR et al. | Dietary conjugated linoleic acid reduces PGE2 release and interstitial injury in rat polycystic kidney disease. | 2003 | Kidney Int. | pmid:12969139 |
TAPPEL AL et al. | Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. | 1953 | Arch. Biochem. Biophys. | pmid:13031632 |
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pmid:13272072 | ||||
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pmid:13489152 | ||||
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pmid:13621280 | ||||
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pmid:13652745 | ||||
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pmid:13673307 | ||||
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