Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Park CW et al. | Inclusion complex of conjugated linoleic acid (CLA) with cyclodextrins. | 2002 | J. Agric. Food Chem. | pmid:11982428 |
Hung CY and Yen GC | Antioxidant activity of phenolic compounds isolated from Mesona procumbens Hemsl. | 2002 | J. Agric. Food Chem. | pmid:11982431 |
Terpstra AH et al. | The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta. | 2002 | J. Nutr. | pmid:11983818 |
Stepień K et al. | Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins. | 2000 | Acta Biochim. Pol. | pmid:11996116 |
Fremann D et al. | Dietary conjugated linoleic acid (CLA) intake assessment and possible biomarkers of CLA intake in young women. | 2002 | Public Health Nutr | pmid:12001981 |
Corino C et al. | Influence of dietary conjugated linoleic acid on growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits. | 2002 | J. Anim. Sci. | pmid:12002308 |
Madron MS et al. | Effect of extruded full-fat soybeans on conjugated linoleic acid content of intramuscular, intermuscular, and subcutaneous fat in beef steers. | 2002 | J. Anim. Sci. | pmid:12002322 |
Szentmihályi K et al. | Rose hip (Rosa canina L.) oil obtained from waste hip seeds by different extraction methods. | 2002 | Bioresour. Technol. | pmid:12003323 |
Parris N et al. | Effect of endogenous triacylglycerol hydrolysates on the mechanical properties of Zein films from ground corn. | 2002 | J. Agric. Food Chem. | pmid:12010002 |
RodrÃguez E et al. | Trans-10, cis-12, but not cis-9, trans-11 CLA isomer, inhibits brown adipocyte thermogenic capacity. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12010762 |
Gregório SM et al. | Effect of dietary linoleic acid on the progression of chronic renal failure in rats. | 2002 | Braz. J. Med. Biol. Res. | pmid:12011943 |
Hennig B et al. | PCB-induced oxidative stress in endothelial cells: modulation by nutrients. | 2002 | Int J Hyg Environ Health | pmid:12018021 |
Yu Y et al. | Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. | 2002 | Biochim. Biophys. Acta | pmid:12020636 |
Lecka-Czernik B et al. | Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. | 2002 | Endocrinology | pmid:12021203 |
Bull AW et al. | Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase. | 2002 | Biochim. Biophys. Acta | pmid:12031293 |
Dobbins RL et al. | The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. | 2002 | Diabetes | pmid:12031970 |
Penumetcha M et al. | Enhanced solubilization and intestinal absorption of cholesterol by oxidized linoleic acid. | 2002 | J. Lipid Res. | pmid:12032164 |
Dufour C et al. | Gallic esters of sucrose as efficient radical scavengers in lipid peroxidation. | 2002 | J. Agric. Food Chem. | pmid:12033806 |
Akahoshi A et al. | Conjugated linoleic acid reduces body fats and cytokine levels of mice. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036077 |
Dunbar BL and Bauer JE | Conversion of essential fatty acids by Delta 6-desaturase in dog liver microsomes. | 2002 | J. Nutr. | pmid:12042499 |
Banni S | Conjugated linoleic acid metabolism. | 2002 | Curr. Opin. Lipidol. | pmid:12045395 |
Sijben JW et al. | Interactions of dietary polyunsaturated fatty acids and vitamin E with regard to vitamin E status, fat composition and antibody responsiveness in layer hens. | 2002 | Br. Poult. Sci. | pmid:12047096 |
Mantzouridou F et al. | Optimization of beta-carotene production from synthetic medium by Blakeslea trispora: a mathematical modeling. | 2002 | Appl. Biochem. Biotechnol. | pmid:12049204 |
Belury MA | Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. | 2002 | Annu. Rev. Nutr. | pmid:12055356 |
Adlof RO et al. | Analysis of conjugated linoleic acid-enriched triacylglycerol mixtures by isocratic silver-ion high-performance liquid chromatography. | 2002 | J Chromatogr A | pmid:12058943 |
Laaksonen DE et al. | Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. | 2002 | Diabet. Med. | pmid:12060056 |
Culbertson SM et al. | Determination of the alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein. | 2002 | Chem. Res. Toxicol. | pmid:12067255 |
Thuillier P et al. | Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. | 2002 | Biochem. J. | pmid:12069687 |
Waylan AT et al. | Effects of modified tall oil and vitamin E on growth performance, carcass characteristics, and meat quality of growing-finishing pigs. | 2002 | J. Anim. Sci. | pmid:12078739 |
Averette Gatlin L et al. | The effects of dietary fat sources, levels, and feeding intervals on pork fatty acid composition. | 2002 | J. Anim. Sci. | pmid:12078742 |
Iwamoto M et al. | Serum lipid profiles in Japanese women and men during consumption of walnuts. | 2002 | Eur J Clin Nutr | pmid:12080402 |
Watanabe Y et al. | Suppressive effect of saturated acyl L-ascorbate on the oxidation of linoleic acid encapsulated with maltodextrin or gum arabic by spray-drying. | 2002 | J. Agric. Food Chem. | pmid:12083870 |
Yu L et al. | Conjugated linoleic acid isomers differ in their free radical scavenging properties. | 2002 | J. Agric. Food Chem. | pmid:12083897 |
Ward AT et al. | Bovine milk fatty acid profiles produced by feeding diets containing solin, flax and canola. | 2002 | J. Dairy Sci. | pmid:12086055 |
Robinson RS et al. | Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. | 2002 | Reproduction | pmid:12090925 |
Stark KD et al. | Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil. | 2002 Jul-Aug | Nutrition | pmid:12093443 |
Wolfe RR et al. | Dietary fat composition alters pulmonary function in pigs. | 2002 Jul-Aug | Nutrition | pmid:12093447 |
Ealey KN et al. | Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats. | 2001 | Nutr Cancer | pmid:12094611 |
Park HJ et al. | Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. | 2001 | Nutr Cancer | pmid:12094615 |
Banni S et al. | Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | 2001 | Nutr Cancer | pmid:12094634 |
Pillai MG et al. | Biosynthesis of triacylglycerol molecular species in an oleaginous fungus, Mortierella ramanniana var. angulispora. | 2002 | J. Biochem. | pmid:12097168 |
Hontecillas R et al. | Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. | 2002 | J. Nutr. | pmid:12097686 |
Kimura Y | Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. | 2002 | J. Nutr. | pmid:12097695 |
Barros MF et al. | Cord blood essential fatty acid and alpha-tocopherol in full-term newborns in a Northeast Brazil area. | 2002 | Int J Vitam Nutr Res | pmid:12098883 |
Chajès V et al. | Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12101117 |
Zhao X et al. | Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox). | 2002 | J. Biol. Chem. | pmid:12101222 |
Anwar F et al. | Analytical characterization of Salicornia bigelovii seed oil cultivated in Pakistan. | 2002 | J. Agric. Food Chem. | pmid:12105947 |
Østdal H et al. | Reaction between protein radicals and other biomolecules. | 2002 | Free Radic. Biol. Med. | pmid:12106816 |
Schlame M et al. | Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. | 2002 | Ann. Neurol. | pmid:12112112 |
Shinohara R et al. | Evaluation of antilipid peroxidative action of propolis ethanol extract. | 2002 | Phytother Res | pmid:12112290 |