Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lasa A et al. | Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. | 2011 | Nutrition | pmid:20619605 |
| Tan B et al. | Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. | 2011 | J. Nutr. Biochem. | pmid:20619625 |
| Shirakawa J et al. | Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. | 2011 | J. Biol. Chem. | pmid:21613229 |
| Wang L et al. | Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. | 2011 | J. Endocrinol. | pmid:21565851 |
| Gelhaus SL et al. | Cellular lipid extraction for targeted stable isotope dilution liquid chromatography-mass spectrometry analysis. | 2011 | J Vis Exp | pmid:22127066 |
| Cunnane SC and Guesnet P | Linoleic acid recommendations--A house of cards. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21963263 |
| Royan M et al. | Effects of conjugated linoleic acid, fish oil and soybean oil on PPARs (α & γ) mRNA expression in broiler chickens and their relation to body fat deposits. | 2011 | Int J Mol Sci | pmid:22272093 |
| Salleh WM et al. | Chemical compositions, antioxidant and antimicrobial activities of essential oils of Piper caninum Blume. | 2011 | Int J Mol Sci | pmid:22174627 |
| Amtul Z et al. | Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids. | 2011 | J. Neurosci. Res. | pmid:21748777 |
| Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
| Espinosa-Neira R et al. | Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. | 2011 | Int. J. Biochem. Cell Biol. | pmid:21945809 |
| Mito F et al. | Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch. | 2011 | Free Radic. Res. | pmid:21736483 |
| Ranchordas MK et al. | A-z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 23. | 2011 | Br J Sports Med | pmid:21743106 |
| Yahya A et al. | Effect of J-coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T. | 2011 | J Magn Reson Imaging | pmid:21953706 |
| Mahmmoud YA and Christensen SB | Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. | 2011 | Biochim. Biophys. Acta | pmid:21767529 |
| Cai W et al. | 3,4,4'-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent. | 2011 | Free Radic. Res. | pmid:21974738 |
| Banta JP et al. | Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. | 2011 | J. Anim. Sci. | pmid:21788431 |
| Danish HH et al. | Hydrogen tunneling steps in cyclooxygenase-2 catalysis. | 2011 | J. Am. Chem. Soc. | pmid:21902213 |
| Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
| Beker BY et al. | Antioxidant protective effect of flavonoids on linoleic acid peroxidation induced by copper(II)/ascorbic acid system. | 2011 | Chem. Phys. Lipids | pmid:21925488 |
| Ogawa E et al. | Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. | 2011 | J. Invest. Dermatol. | pmid:21068754 |
| Arciniega JC et al. | Effects of free fatty acids on meibomian lipid films. | 2011 | Exp. Eye Res. | pmid:21718696 |
| Vinaixa M et al. | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. | 2011 | PLoS ONE | pmid:22194988 |
| Yang Y et al. | Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. | 2011 | Free Radic. Res. | pmid:21128731 |
| Jin G et al. | Crude lipoxygenase from pig muscle: partial characterization and interactions of temperature, NaCl and pH on its activity. | 2011 | Meat Sci. | pmid:21093161 |
| Du YZ et al. | Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. | 2011 | Int. J. Biol. Macromol. | pmid:21093477 |
| Huang YS et al. | Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. | 2011 | Mol. Cell. Biochem. | pmid:21688154 |
| Gorissen L et al. | Linoleate isomerase activity occurs in lactic acid bacteria strains and is affected by pH and temperature. | 2011 | J. Appl. Microbiol. | pmid:21699633 |
| Rybicka M et al. | Comparative effects of conjugated linoleic acid (CLA) and linoleic acid (LA) on the oxidoreduction status in THP-1 macrophages. | 2011 | J. Agric. Food Chem. | pmid:21391598 |
| Rakib MA et al. | Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells. | 2011 | J. Agric. Food Chem. | pmid:21391601 |
| Tuei VC et al. | Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. | 2011 | Life Sci. | pmid:21396379 |
| Mihaljević B et al. | Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. | 2011 | Org. Biomol. Chem. | pmid:21442126 |
| Conforti F et al. | Correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in Calabria (South Italy). | 2011 | Chem. Biodivers. | pmid:21404435 |
| Edris AE | The chemical composition and the content of volatile oil: potential factors that can contribute to the oxidative stability of Nigella sativa L. crude oil. | 2011 | J Diet Suppl | pmid:22432633 |
| Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
| Min Y et al. | Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity. | 2011 | Eur J Clin Nutr | pmid:21386858 |
| Negrini R and Mezzenga R | pH-responsive lyotropic liquid crystals for controlled drug delivery. | 2011 | Langmuir | pmid:21452814 |
| Ferreira TC et al. | Cell density-dependent linoleic acid toxicity to Saccharomyces cerevisiae. | 2011 | FEMS Yeast Res. | pmid:21457450 |
| Sala-Vila A et al. | Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia. | 2011 | Clin Nutr | pmid:21458117 |
| Ueda Y et al. | Effect of dietary lipids on longevity and memory in the SAMP8 mice. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:21512289 |
| Atri MS et al. | Structure and stability analysis of cytotoxic complex of camel α-lactalbumin and unsaturated fatty acids produced at high temperature. | 2011 | J. Biomol. Struct. Dyn. | pmid:21469752 |
| Carrillo C et al. | Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. | 2011 | Cell. Physiol. Biochem. | pmid:21471726 |
| Subbaiah PV et al. | Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. | 2011 | Biochim. Biophys. Acta | pmid:20920595 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Figueras M et al. | Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. | 2011 | Obesity (Silver Spring) | pmid:20885391 |
| Liou AP et al. | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | 2011 | Gastroenterology | pmid:20955703 |
| White HM et al. | Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | 2011 | J. Dairy Sci. | pmid:21700028 |
| Chen HH and Chiu TH | Phytochemicals characterization of solvent extracts from taro-scented japonica rice bran. | 2011 | J. Food Sci. | pmid:22417350 |
| Tuo Y et al. | Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. | 2011 | Endocrine | pmid:21161439 |
| Hamberg M | Stereochemistry of hydrogen removal during oxygenation of linoleic acid by singlet oxygen and synthesis of 11(S)-deuterium-labeled linoleic acid. | 2011 | Lipids | pmid:21161604 |