Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
| May V and Eipper BA | Long term culture of primary rat pituitary adrenocorticotropin/endorphin-producing cells in serum-free medium. | 1986 | Endocrinology | pmid:3004908 |
| Kühn H et al. | The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. | 1986 | Biochim. Biophys. Acta | pmid:3006782 |
| Alexander JW et al. | The importance of lipid type in the diet after burn injury. | 1986 | Ann. Surg. | pmid:3015058 |
| Kelly RA et al. | Identification of NaK-ATPase inhibitors in human plasma as nonesterified fatty acids and lysophospholipids. | 1986 | J. Biol. Chem. | pmid:3017943 |
| Connor HD et al. | A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3026385 |
| Nijssen JG and van den Bosch H | Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3947653 |
| Kryvi H et al. | Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. | 1986 | Biochim. Biophys. Acta | pmid:3947675 |
| De Villiers M and Lochner A | Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. | 1986 | Biochim. Biophys. Acta | pmid:3955069 |
| Madison KC et al. | Lipid composition of cultured murine keratinocytes. | 1986 | J. Invest. Dermatol. | pmid:3090156 |
| Ishiura S et al. | Reticulocyte lipoxygenase, ingensin, and ATP-dependent proteolysis. | 1986 | FEBS Lett. | pmid:3086125 |
| Beneytout JL et al. | Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. | 1986 | Prostaglandins | pmid:3086939 |
| Riemersma RA et al. | Linoleic acid content in adipose tissue and coronary heart disease. | 1986 | Br Med J (Clin Res Ed) | pmid:3087455 |
| Rapoport S et al. | Hydroperoxyfatty acids inactivate the reticulocyte lipoxygenase independently of a hydroperoxidase reaction. | 1986 | FEBS Lett. | pmid:3087777 |
| Heagerty AM et al. | Influence of dietary linoleic acid on leucocyte sodium transport and blood pressure. | 1986 | Br Med J (Clin Res Ed) | pmid:3089491 |
| Ng LL and Hockaday TD | Influence of dietary linoleic acid on leucocyte sodium transport and blood pressure. | 1986 | Br Med J (Clin Res Ed) | pmid:3092960 |
| Hansen HS et al. | Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. | 1986 | Biochim. Biophys. Acta | pmid:3092868 |
| Chambaz J et al. | Essential fatty acid uptake and esterification in primary culture of rat hepatocytes. | 1986 | Biochim. Biophys. Acta | pmid:3092869 |
| Kanofsky JR and Axelrod B | Singlet oxygen production by soybean lipoxygenase isozymes. | 1986 | J. Biol. Chem. | pmid:3080416 |
| Renner F et al. | Effect of saturated and unsaturated lipid on the composition of mesenteric triglyceride-rich lipoproteins in the rat. | 1986 | J. Lipid Res. | pmid:3083032 |
| Kanazawa K et al. | The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3768385 |
| Feingold KR et al. | Effect of essential fatty acid deficiency on cutaneous sterol synthesis. | 1986 | J. Invest. Dermatol. | pmid:3772153 |
| Jones DB et al. | Indirect evidence of impairment of platelet desaturase enzymes in diabetes mellitus. | 1986 | Horm. Metab. Res. | pmid:3013745 |
| Hansen HS and Jensen B | Urinary excretion of arginine-vasopressin and prostaglandin E2 in essential fatty acid-deficient rats after oral supplementation with unsaturated fatty acid esters. | 1986 | J. Nutr. | pmid:3080561 |
| Okabe H et al. | Effects of anti-convulsants on fatty acid metabolism in human serum. | 1986 | Tohoku J. Exp. Med. | pmid:3705068 |
| Leikin AI and Brenner RR | Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. | 1986 | Biochim. Biophys. Acta | pmid:2869785 |
| Carlson SE et al. | High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. | 1986 | J. Nutr. | pmid:2871142 |
| Nijssen JG and van den Bosch H | Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3081034 |
| Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
| Lee SH and Clandinin MT | Effect of dietary fat on the utilization of fatty acids by myocardial tissue in the rat. | 1986 | J. Nutr. | pmid:3794820 |
| Szebeni J et al. | Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. | 1986 | Alcohol. Clin. Exp. Res. | pmid:3101533 |
| Morson LA and Clandinin MT | Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. | 1986 | J. Nutr. | pmid:2879899 |
| Andre JC and Funk MO | Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. | 1986 | Anal. Biochem. | pmid:3101541 |
| Heleniak EP and Lamola SW | A new prostaglandin disturbance syndrome in schizophrenia: delta-6-pyroluria. | 1986 | Med. Hypotheses | pmid:3520252 |
| Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
| Koletzko B et al. | Comparison of fatty acid composition of plasma lipid fractions in well-nourished Nigerian and German infants and toddlers. | 1986 Jul-Aug | J. Pediatr. Gastroenterol. Nutr. | pmid:3090220 |
| Lester LA et al. | Supplemental parenteral nutrition in cystic fibrosis. | 1986 May-Jun | JPEN J Parenter Enteral Nutr | pmid:3086588 |
| Melton JL et al. | Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. | 1987 | Biochim. Biophys. Acta | pmid:3651483 |
| Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. | 1987 | Am. J. Clin. Nutr. | pmid:3310599 |
| Levay-Young BK et al. | Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3317407 |
| Colard O et al. | Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. | 1987 | Biochim. Biophys. Acta | pmid:3115303 |
| Taylor AJ et al. | An alternative explanation for the changes in erythrocyte fatty acids observed in diabetes mellitus. | 1987 | Clin. Chem. | pmid:3119255 |
| Bomalaski JS et al. | Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. | 1987 | Biochem. Pharmacol. | pmid:3117063 |
| Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
| Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
| Clementz T et al. | Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. | 1987 | Biochim. Biophys. Acta | pmid:3567184 |
| Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
| Hubbard NE and Erickson KL | Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid. | 1987 | Cancer Res. | pmid:3677068 |
| Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
| Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |