Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Acute Coronary Syndrome D054058 11 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Restenosis D023903 10 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Circoviridae Infections D018173 2 associated lipids
Glucose Intolerance D018149 13 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Hyperpigmentation D017495 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Helicobacter Infections D016481 21 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Tuberculosis D014376 20 associated lipids
Thrombosis D013927 49 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Seizures D012640 87 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Precancerous Conditions D011230 48 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pain D010146 64 associated lipids
Otitis Externa D010032 8 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Melanosis D008548 4 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Lymphopenia D008231 2 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Diseases D008107 31 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Leukemia D007938 74 associated lipids
Lactose Intolerance D007787 2 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Kidney Diseases D007674 29 associated lipids
Insulin Resistance D007333 99 associated lipids
Inflammation D007249 119 associated lipids
Hypertension, Renal D006977 9 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Lee YJ and Jenkins TC Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. 2011 J. Microbiol. pmid:21887646
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Edwards SJ et al. Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase. 2010 J Phys Chem B pmid:20423074
Patwardhan AM et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. 2010 J. Clin. Invest. pmid:20424317
Brown DA and Passmore GM Some new insights into the molecular mechanisms of pain perception. 2010 J. Clin. Invest. pmid:20424321
Even P et al. Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. 2010 Metab. Clin. Exp. pmid:19775712
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Kim BS et al. Effect of surfactant on the production of oxygenated unsaturated fatty acids by Bacillus megaterium ALA2. 2010 N Biotechnol pmid:19748603
Joshi SC et al. Antioxidant and antibacterial activities of the leaf essential oils of Himalayan Lauraceae species. 2010 Food Chem. Toxicol. pmid:19766161
Lu XF et al. Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes. 2010 J Zhejiang Univ Sci B pmid:21121070
Luo H et al. The In vitro antioxidant properties of chinese highland lichens. 2010 J. Microbiol. Biotechnol. pmid:21124057
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Domínguez T et al. Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. 2010 Plant Physiol. pmid:20382895
Wan ZX et al. Lipid content and fatty acids composition of mature human milk in rural North China. 2010 Br. J. Nutr. pmid:19825220
Li Z et al. Dual response surface-optimized synthesis of L-menthyl conjugated linoleate in solvent-free system by Candida rugosa lipase. 2010 Bioresour. Technol. pmid:19833506
Lau BY et al. Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. 2010 Appl Physiol Nutr Metab pmid:20962915
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Salehipour M et al. Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells. 2010 Int J Mol Sci pmid:21151462
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