Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lee YJ and Jenkins TC | Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. | 2011 | J. Microbiol. | pmid:21887646 |
Odabasoglu F et al. | α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. | 2011 | Br. J. Nutr. | pmid:21073761 |
Narwaley M et al. | Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites. | 2011 | Chem. Res. Toxicol. | pmid:21671642 |
Briend A et al. | Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. | 2011 | Matern Child Nutr | pmid:21366873 |
Litinas KE et al. | Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers. | 2011 | J Enzyme Inhib Med Chem | pmid:21381887 |
Mariutto M et al. | The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. | 2011 | BMC Plant Biol. | pmid:21294872 |
McCusker MM and Grant-Kels JM | Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. | 2010 Jul-Aug | Clin. Dermatol. | pmid:20620762 |
Zovko Koncić M et al. | Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20488218 |
Hajlaoui H et al. | Chemical composition and biological activities of Tunisian Cuminum cyminum L. essential oil: a high effectiveness against Vibrio spp. strains. | 2010 Aug-Sep | Food Chem. Toxicol. | pmid:20488223 |
Wang L et al. | [Effects of linoleic acid on intracellular calcium concentration in primarily cultured rat pancreatic β-cells and underlying mechanism]. | 2010 | Sheng Li Xue Bao | pmid:21170499 |
Khiaosa-ard R et al. | Methods of emulsifying linoleic acid in biohydrogenation studies in vitro may bias the resulting fatty acid profiles. | 2010 | Lipids | pmid:20582723 |
Brito GA et al. | Lymphocytes transfer [(14)C]-labeled fatty acids to skeletal muscle in culture; modulation by exercise. | 2010 | Cell Biochem. Funct. | pmid:20517891 |
Czernichow S et al. | n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations. | 2010 | Br. J. Nutr. | pmid:20522273 |
Sorrentino F et al. | Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20571794 |
Livraghi S et al. | Decreasing the oxidative potential of TiO(2) nanoparticles through modification of the surface with carbon: a new strategy for the production of safe UV filters. | 2010 | Chem. Commun. (Camb.) | pmid:20938530 |
Tu WC et al. | Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20573490 |
Caroprese M et al. | Flaxseed supplementation improves fatty acid profile of cow milk. | 2010 | J. Dairy Sci. | pmid:20494167 |
Wien M et al. | Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. | 2010 | Lipids | pmid:20496049 |
Can-Karabulut DC et al. | Influence of experimental provisional cements containing zeolite, bone hydroxyapatite and linoleic Acid on bond strength of composite to dentin in vitro. | 2010 | J Adhes Dent | pmid:20157651 |
Biro A et al. | Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. | 2010 | Biochemistry | pmid:20166680 |
Sarikurkcu C et al. | Evaluation of metal concentration and antioxidant activity of three edible mushrooms from Mugla, Turkey. | 2010 | Food Chem. Toxicol. | pmid:20167240 |
Vukovic N et al. | An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins. | 2010 | Arch. Pharm. Res. | pmid:20191339 |
Pauloin A et al. | Oleate and linoleate stimulate degradation of β-casein in prolactin-treated HC11 mouse mammary epithelial cells. | 2010 | Cell Tissue Res. | pmid:20182891 |
Gammill W et al. | Comparative study of high-linoleic acid vegetable oils for the production of conjugated linoleic acid. | 2010 | J. Agric. Food Chem. | pmid:20136082 |
Harris W | Omega-6 and omega-3 fatty acids: partners in prevention. | 2010 | Curr Opin Clin Nutr Metab Care | pmid:20145438 |
Goebel AS et al. | Dermal targeting using colloidal carrier systems with linoleic acid. | 2010 | Eur J Pharm Biopharm | pmid:20170728 |
Edwards SJ et al. | Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase. | 2010 | J Phys Chem B | pmid:20423074 |
Patwardhan AM et al. | Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. | 2010 | J. Clin. Invest. | pmid:20424317 |
Brown DA and Passmore GM | Some new insights into the molecular mechanisms of pain perception. | 2010 | J. Clin. Invest. | pmid:20424321 |
Even P et al. | Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. | 2010 | Metab. Clin. Exp. | pmid:19775712 |
Li YF et al. | Properties of synthetic homoisoflavonoids to reduce oxidants and to protect linoleic acid and dna against oxidation. | 2010 | J. Agric. Food Chem. | pmid:20199083 |
Kim BS et al. | Effect of surfactant on the production of oxygenated unsaturated fatty acids by Bacillus megaterium ALA2. | 2010 | N Biotechnol | pmid:19748603 |
Joshi SC et al. | Antioxidant and antibacterial activities of the leaf essential oils of Himalayan Lauraceae species. | 2010 | Food Chem. Toxicol. | pmid:19766161 |
Lu XF et al. | Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes. | 2010 | J Zhejiang Univ Sci B | pmid:21121070 |
Luo H et al. | The In vitro antioxidant properties of chinese highland lichens. | 2010 | J. Microbiol. Biotechnol. | pmid:21124057 |
Olszewska MA et al. | Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus Sorbus sensu stricto. | 2010 | Molecules | pmid:21127463 |
Duckett SK and Gillis MH | Effects of oil source and fish oil addition on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. | 2010 | J. Anim. Sci. | pmid:20348369 |
Chen T et al. | Analytical characterization of Hempseed (seed of Cannabis sativa L.) oil from eight regions in China. | 2010 | J Diet Suppl | pmid:22435611 |
Georgiadi A et al. | Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. | 2010 | Circ. Res. | pmid:20378851 |
Zulkifli RM et al. | Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. | 2010 | J. Anim. Sci. | pmid:20382866 |
DomÃnguez T et al. | Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. | 2010 | Plant Physiol. | pmid:20382895 |
Wan ZX et al. | Lipid content and fatty acids composition of mature human milk in rural North China. | 2010 | Br. J. Nutr. | pmid:19825220 |
Li Z et al. | Dual response surface-optimized synthesis of L-menthyl conjugated linoleate in solvent-free system by Candida rugosa lipase. | 2010 | Bioresour. Technol. | pmid:19833506 |
Lau BY et al. | Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. | 2010 | Appl Physiol Nutr Metab | pmid:20962915 |
Giroix MH et al. | Fatty acid pattern of pancreatic islet lipids in Goto-Kakizaki rats. | 2010 | Endocrine | pmid:20963567 |
Corriher VA et al. | Pigeon peas as a supplement for lactating dairy cows fed corn silage-based diets. | 2010 | J. Dairy Sci. | pmid:20965347 |
Martin H | Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. | 2010 | Mutat. Res. | pmid:20973164 |
McKay DL et al. | Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. | 2010 | Nutr J | pmid:20462428 |
Salehipour M et al. | Polyunsaturated fatty acids and modulation of cholesterol homeostasis in THP-1 macrophage-derived foam cells. | 2010 | Int J Mol Sci | pmid:21151462 |
Alloatti A et al. | Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. | 2010 | PLoS ONE | pmid:21151902 |