Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Hannah JS et al. | High fat, high cholesterol diets alter low density lipoprotein size and binding affinity in monkeys. | 1997 | Atherosclerosis | pmid:9247355 |
Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
Margetts BM et al. | Dietary fats and blood pressure. | 1984 | Aust N Z J Med | pmid:6596055 |
De Weirdt R et al. | A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. | 2013 | Benef Microbes | pmid:24311313 |
Oliw EH | Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6301473 |
Pal S and Davis PJ | N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2260969 |
Blee E et al. | Regio- and stereoselectivity of cytochrome P-450 and peroxygenase-dependent formation of cis-12,13-epoxy-9(Z)-octadecenoic acid (vernolic acid) in Euphorbia lagascae. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267615 |
Iwase H et al. | Monoepoxide production from linoleic acid by cytochrome c in the presence of cardiolipin. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630079 |
Garscha U and Oliw E | Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18586008 |
Iwase H et al. | Superoxide anion reduces the ability of myeloperoxidase to damage lipids. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8605038 |
Kotarsky K et al. | A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565875 |
Wooten MW and Wrenn RW | Linoleic acid is a potent activator of protein kinase C type III-alpha isoform in pancreatic acinar cells; its role in amylase secretion. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2454109 |
Canfield LM et al. | Anti-oxidant/pro-oxidant reactions of vitamin K. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985964 |
Byczkowski JZ and Kulkarni AP | Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2494999 |
Kapich A et al. | Coupling of manganese peroxidase-mediated lipid peroxidation with destruction of nonphenolic lignin model compounds and 14C-labeled lignins. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334942 |
Jung KC et al. | Determination of the dissociation constants for recombinant c-Myc, Max, and DNA complexes: the inhibitory effect of linoleic acid on the DNA-binding step. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16002048 |
Sakurada K et al. | cis-9,10-Methylenehexadecanoic acid inhibits contractility and actomyosin ATPase activity of guinea pig myocardium. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913372 |
van Himbergen TM et al. | Paraoxonase-1 and linoleic acid oxidation in familial hypercholesterolemia. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15963464 |
Iwase H et al. | Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070266 |
McPherson PA et al. | Mechanism for the enhanced peroxidation of linoleic acid by a titanium dioxide/hypochlorite system. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23178466 |
Andrianarison RH et al. | Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1953704 |
Ding XZ et al. | Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10405349 |
Takahashi K et al. | Ester-exchange catalyzed by lipase modified with polyethylene glycol. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4052065 |
Whitehouse AS and Tisdale MJ | Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11453634 |
Giamalva D et al. | A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084297 |
Kambayashi Y et al. | Preferential hydrolysis of oxidized phosphatidylcholine in cholesterol-containing phosphatidylcholine liposome by phospholipase A2. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9588178 |
Hrelia S et al. | Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2570573 |
Rose DP and Connolly JM | Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803300 |
Aki T et al. | Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049752 |
Matsumoto M et al. | D-galactosamine-induced cell damage enhances specific binding of prostaglandin E1 to rat hepatocytes. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1315527 |
Nikolaev V et al. | Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2116790 |
Reddy N et al. | Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070230 |
Jacobs JM and Jacobs NJ | Effect of unsaturated fatty acids on protoporphyrinogen oxidation, a step in heme and chlorophyll synthesis in plant organelles. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6487324 |
Mullarkey CJ et al. | Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2176495 |
Chu CH et al. | The activity of 3-hydroxyacyl-CoA epimerase is insufficient to account for the rate of linoleate oxidation in rat heart mitochondria. Evidence for a modified pathway of linoleate degradation. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696754 |
Tannin-Spitz T et al. | Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17942079 |
Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |
Jiang WG et al. | Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514943 |
Lee JY and Hwang DH | Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12419306 |
Kang K et al. | Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14975733 |
Breton M et al. | Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6230079 |
Aleynik MK and Lieber CS | Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11689017 |
Chapkin RS and Ziboh VA | Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6439197 |
Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
Verma SP and Wallach DF | Action of ionizing radiation on lipid-protein interaction. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6896453 |
Fávaro RD et al. | ZmPUMP encodes a fully functional monocot plant uncoupling mitochondrial protein whose affinity to fatty acid is increased with the introduction of a His pair at the second matrix loop. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16603126 |
Wang S et al. | Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26879142 |
Das UN | Effect of phorbolmyristate acetate on fatty acid uptake and distribution in human promyelocytic leukemia (HL-60) cells in vitro. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144272 |
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
Zhao G et al. | Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16169525 |