Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watkins BA et al. | Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. | 1996 | Proc. Soc. Exp. Biol. Med. | pmid:8650253 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
| Cunnane SC | Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. | 1982 | Prog. Lipid Res. | pmid:7051042 |
| Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
| Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
| Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
| Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
| Houtsmuller UM and van der Beek A | Effects of topical application of fatty acids. | 1981 | Prog. Lipid Res. | pmid:6804961 |
| Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
| Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
| Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
| Mercuri O and De Tomás ME | Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. | 1981 | Prog. Lipid Res. | pmid:6804968 |
| Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
| Beneytout JL et al. | Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. | 1986 | Prostaglandins | pmid:3086939 |
| Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |
| Bull AW et al. | Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. | 1991 | Prostaglandins | pmid:2020745 |
| Andersen BR et al. | The effects of arachidonic and other fatty acids on canine neutrophil metabolism. | 1981 | Prostaglandins | pmid:6795686 |
| Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
| Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |