Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Stachowska E et al. | Exchange of unsaturated fatty acids between adipose tissue and atherosclerotic plaque studied with artificial neural networks. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643180 |
Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
Whelan J | The health implications of changing linoleic acid intakes. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990554 |
Harris WS | Linoleic acid and coronary heart disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951772 |
Adam O et al. | Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973995 |
Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
Mouradian M et al. | Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24374147 |
Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
Iwakiri Y et al. | Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by conjugated linoleic acid in murine macrophages. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468265 |
Kikuchi S et al. | Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610849 |
Villa PM et al. | Free fatty acid profiles in preeclampsia. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19497719 |
Peet M et al. | Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888126 |
Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
Gregor JI et al. | Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16226437 |
Novak EM et al. | Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22365109 |
Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
Turpeinen AM et al. | A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844997 |
Louw L | Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090251 |