Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alzate A et al. | Preeclampsia prevention: a case-control study nested in a cohort. | 2015 | Colomb. Med. | pmid:26848195 |
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| Valenzuela R et al. | Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. | 2015 | Nutrients | pmid:26247968 |
| Tucker RM et al. | No Difference in Perceived Intensity of Linoleic Acid in the Oral Cavity between Obese and Nonobese Individuals. | 2015 | Chem. Senses | pmid:26232811 |
| Evans SJ et al. | Plasma linoleic acid partially mediates the association of bipolar disorder on self-reported mental health scales. | 2015 | J Psychiatr Res | pmid:26228402 |
| Min JS et al. | Monitoring the formation of cholesterol oxidation products in model systems using response surface methodology. | 2015 | Lipids Health Dis | pmid:26201850 |
| Farvid MS et al. | Response to Letters Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195494 |
| Lucas M | Letter by Lucas Regarding Articles, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies" and "Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study". | 2015 | Circulation | pmid:26195492 |
| Hoenselaar R | Letter by Hoenselaar Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195491 |
| Yuan T et al. | Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. | 2015 | Int J Clin Exp Pathol | pmid:26191198 |
| Marinho GS et al. | Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. | 2015 | Mar Drugs | pmid:26184241 |
| Salehi R et al. | A prepartum diet supplemented with oilseeds high in oleic or linoleic acid reduced GnRH-induced LH release in dairy cows during second week postpartum. | 2015 | Reprod. Biol. Endocrinol. | pmid:26138920 |
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| Fajardo VA et al. | Cardiolipin linoleic acid content and mitochondrial cytochrome c oxidase activity are associated in rat skeletal muscle. | 2015 | Chem. Phys. Lipids | pmid:25727371 |
| Vlachogianni IC et al. | In vitro assessment of antioxidant activity of tyrosol, resveratrol and their acetylated derivatives. | 2015 | Food Chem | pmid:25660873 |
| Hernandez LR et al. | Effect of plant growth regulators on fatty acids composition in Jatropha curcas L. callus culture. | 2015 | J Oleo Sci | pmid:25757437 |
| Kotani K et al. | Enzymatic preparation of human milk fat substitutes and their oxidation stability. | 2015 | J Oleo Sci | pmid:25757431 |
| Hashim RB et al. | Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. | 2015 | J Oleo Sci | pmid:25748380 |
| Chang TS et al. | Palm oil derived trimethylolpropane triesters synthetic lubricants and usage in industrial metalworking fluid. | 2015 | J Oleo Sci | pmid:25748374 |
| Askari M et al. | Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. | 2015 | Clin Transl Oncol | pmid:25351172 |
| Tyurina YY et al. | LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. | 2015 | Free Radic. Res. | pmid:25740198 |
| Wang S et al. | Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes. | 2015 | J. Nutr. | pmid:25733475 |
| Nardi F et al. | Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability. | 2015 | J. Biol. Chem. | pmid:25653282 |
| Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
| Baylin A et al. | Serum Trans Fatty Acids Are Not Associated with Weight Gain or Linear Growth in School-Age Children. | 2015 | J. Nutr. | pmid:26180252 |
| Fala AM et al. | Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. | 2015 | Sci Rep | pmid:26237540 |
| Beam J et al. | Excess Linoleic Acid Increases Collagen I/III Ratio and "Stiffens" the Heart Muscle Following High Fat Diets. | 2015 | J. Biol. Chem. | pmid:26240151 |
| Okazaki H et al. | Bongkrekic acid as a selective activator of the peroxisome proliferator-activated receptor γ (PPARγ) isoform. | 2015 | J Toxicol Sci | pmid:25786526 |
| Naughton SS et al. | Australia's nutrition transition 1961-2009: a focus on fats. | 2015 | Br. J. Nutr. | pmid:26123446 |
| Salazar MO et al. | A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. | 2014 Mar-Apr | Phytochem Anal | pmid:24185747 |
| Mesti T et al. | Metabolic impact of anti-angiogenic agents on U87 glioma cells. | 2014 | PLoS ONE | pmid:24922514 |
| Herchi W et al. | Flaxseed hull: Chemical composition and antioxidant activity during development. | 2014 | J Oleo Sci | pmid:24919478 |
| Woyda-Ploszczyca AM and Jarmuszkiewicz W | Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. | 2014 | PLoS ONE | pmid:24904988 |
| Maruyama H et al. | Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. | 2014 | Lipids Health Dis | pmid:24885871 |
| Nosaka S and Miyazawa M | Characterization of volatile components and odor-active compounds in the oil of edible mushroom Boletopsis leucomelas. | 2014 | J Oleo Sci | pmid:24881770 |
| Mouradian M et al. | Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24374147 |
| Choi JI et al. | Development of microalga Scenedesmus dimorphus mutant with higher lipid content by radiation breeding. | 2014 | Bioprocess Biosyst Eng | pmid:24871276 |
| Guo HH et al. | XsFAD2 gene encodes the enzyme responsible for the high linoleic acid content in oil accumulated in Xanthoceras sorbifolia seeds. | 2014 | J. Sci. Food Agric. | pmid:23775588 |
| Usami A et al. | Characteristic odorants from bailingu oyster mushroom (Pleurotus eryngii var. tuoliensis) and summer oyster mushroom (Pleurotus cystidiosus). | 2014 | J Oleo Sci | pmid:24919476 |
| López-Cervantes J et al. | Effect of solvents and methods of stirring in extraction of lycopene, oleoresin and fatty acids from over-ripe tomato. | 2014 | Int J Food Sci Nutr | pmid:24111501 |
| Wennman A et al. | Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. | 2014 | Arch. Biochem. Biophys. | pmid:24857825 |
| López A et al. | Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model. | 2014 | J Mech Behav Biomed Mater | pmid:24508711 |
| Stoffel W et al. | Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. | 2014 | EMBO Rep. | pmid:24378641 |
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| Choi JS et al. | In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. | 2014 | Biol. Pharm. Bull. | pmid:24389480 |
| Ozdener MH et al. | CD36- and GPR120-mediated Ca²⺠signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. | 2014 | Gastroenterology | pmid:24412488 |
| Youn K et al. | Oleic acid and linoleic acid from Tenebrio molitor larvae inhibit BACE1 activity in vitro: molecular docking studies. | 2014 | J Med Food | pmid:24548007 |