Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. | 1987 | Am. J. Clin. Nutr. | pmid:3310599 |
KRAUSE RF | LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A. | 1965 | Am. J. Clin. Nutr. | pmid:14301352 |
Turpeinen AM et al. | Bioconversion of vaccenic acid to conjugated linoleic acid in humans. | 2002 | Am. J. Clin. Nutr. | pmid:12197992 |
DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
Martin JC et al. | Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. | 1991 | Am. J. Clin. Nutr. | pmid:1951153 |
HOLMAN RT et al. | ESTIMATION OF LINOLEATE INTAKE OF MEN FROM SERUM LIPID ANALYSIS. | 1964 | Am. J. Clin. Nutr. | pmid:14142377 |
Rudel LL et al. | Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. | 1995 | Am. J. Clin. Nutr. | pmid:7625361 |
Reeves VB et al. | Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. | 1984 | Am. J. Clin. Nutr. | pmid:6507356 |
Gibson RA and Makrides M | n-3 polyunsaturated fatty acid requirements of term infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617980 |
Crawford M | Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617983 |
Dutta-Roy AK | Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. | 2000 | Am. J. Clin. Nutr. | pmid:10617989 |
Blair IA et al. | Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. | 1993 | Am. J. Clin. Nutr. | pmid:8424383 |
Ziboh VA et al. | Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. | 2000 | Am. J. Clin. Nutr. | pmid:10617998 |
Kalivianakis M et al. | Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. | 1999 | Am. J. Clin. Nutr. | pmid:9925134 |
Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
Brosnan MJ and Carkner RD | Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat. | 2008 | Am. J. Hypertens. | pmid:18437120 |
Taylor EN et al. | Fatty acid intake and incident nephrolithiasis. | 2005 | Am. J. Kidney Dis. | pmid:15685503 |
Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
Weiss LA et al. | The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. | 2012 | Am. J. Med. Genet. A | pmid:22315197 |
SCHWARTZ S et al. | LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. | 1965 | Am. J. Med. Sci. | pmid:14254823 |
Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
Kääpä P et al. | Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. | 1986 | Am. J. Obstet. Gynecol. | pmid:3089014 |
MacKenzie LW et al. | Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. | 1988 | Am. J. Obstet. Gynecol. | pmid:3144917 |
Vaughan JE and Walsh SW | Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. | 2005 | Am. J. Obstet. Gynecol. | pmid:16150282 |
Liu H et al. | Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. | 2015 | Am. J. Pathol. | pmid:25447051 |
McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
Thomson AB et al. | A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. | 1987 | Am. J. Physiol. | pmid:3826353 |
Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
Murray MJ et al. | Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. | 1993 | Am. J. Physiol. | pmid:8279548 |
Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
West DB et al. | Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. | 1998 | Am. J. Physiol. | pmid:9728060 |
GOLD M and SPITZER JJ | METABOLISM OF FREE FATTY ACIDS BY MYOCARDIUM AND KIDNEY. | 1964 | Am. J. Physiol. | pmid:14111431 |
SPITZER JJ and GOLD M | FREE FATTY ACID METABOLISM BY SKELETAL MUSCLE. | 1964 | Am. J. Physiol. | pmid:14111432 |
ERWIN ES and STERNER W | DIETARY LIPIDS AND FATTY ACID DEPOSITION IN VARIOUS CALF TISSUES. | 1963 | Am. J. Physiol. | pmid:14084975 |
Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
Thomas ME et al. | Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. | 1995 | Am. J. Physiol. | pmid:7611458 |
Spalinger JH et al. | Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. | 1998 | Am. J. Physiol. | pmid:9756493 |
Chen ZY et al. | Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. | 1997 | Am. J. Physiol. | pmid:9038989 |
Reddy SR et al. | Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. | 1989 | Am. J. Physiol. | pmid:2764141 |
Le Petit-Thevenin J et al. | Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. | 1991 | Am. J. Physiol. | pmid:1887869 |
Bogdanov KY et al. | Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. | 1998 | Am. J. Physiol. | pmid:9486261 |
Aw TY et al. | Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: role of mucosal GSH. | 1992 | Am. J. Physiol. | pmid:1733274 |
Liu F et al. | Permeability properties of monolayers of the human trophoblast cell line BeWo. | 1997 | Am. J. Physiol. | pmid:9374645 |
Guidot DM et al. | Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. | 1997 | Am. J. Physiol. | pmid:9374722 |
Devor DC and Frizzell RA | Modulation of K+ channels by arachidonic acid in T84 cells. II. Activation of a Ca(2+)-independent K+ channel. | 1998 | Am. J. Physiol. | pmid:9458723 |
Shasby DM et al. | Oxidants and conductance of cultured epithelial cell monolayers: inositol phospholipid hydrolysis. | 1988 | Am. J. Physiol. | pmid:3144179 |
Meyer C et al. | Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. | 1997 | Am. J. Physiol. | pmid:9316458 |
Sebokova E et al. | Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. | 1988 | Am. J. Physiol. | pmid:2897795 |
Ookhtens M and Baker N | Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. | 1983 | Am. J. Physiol. | pmid:6295191 |