Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Alopecia D000505 14 associated lipids
Liver Diseases D008107 31 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Seizures D012640 87 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hypertension, Renal D006977 9 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Aortic Diseases D001018 11 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Ben Bacha A et al. Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain. 2007 Pancreas pmid:17895836
Littman ED et al. Role of protein kinase C isoenzymes in fatty acid stimulation of insulin secretion. 2000 Pancreas pmid:10766451
Ruparel S et al. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. 2012 Pain pmid:22633978
Green DP et al. Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. 2013 Pain pmid:23891895
Ruparel S et al. Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. 2013 Pain pmid:23867730
Jarvis MF Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. 2012 Pain pmid:22681878
Virtanen JK et al. Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. 2012 Osteoporos Int pmid:22270860
Jacquot C et al. Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. 2008 Org. Biomol. Chem. pmid:18972057
Joshi S et al. Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. 2012 Org. Biomol. Chem. pmid:22986997
Mihaljević B et al. Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. 2011 Org. Biomol. Chem. pmid:21442126
Akeo K et al. Effects of superoxide dismutase and catalase on growth of retinal pigment epithelial cells in vitro following addition of linoleic acid or linoleic acid hydroperoxide. 1996 Ophthalmic Res. pmid:8726672
Trimborn M et al. Linoleic acid cytotoxicity to bovine lens epithelial cells: influence of albumin on linoleic acid uptake and cytotoxicity. 2000 Mar-Jun Ophthalmic Res. pmid:10754440
Schumann T et al. Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment. 2015 Oncotarget pmid:25968567
Noguchi M et al. Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). 1995 Nov-Dec Oncology pmid:7478431
Noguchi M et al. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. 1995 Jul-Aug Oncology pmid:7777237
Zuo X et al. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. 2006 Oncogene pmid:16288226
Herrera JA et al. Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. 1998 Obstet Gynecol pmid:9540946
Dailey MJ et al. Nutrient specific feeding and endocrine effects of jejunal infusions. 2010 Obesity (Silver Spring) pmid:20134410
Pinnick KE et al. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. 2008 Obesity (Silver Spring) pmid:18239594
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. 2012 Obesity (Silver Spring) pmid:22334255
Guyenet SJ High-fat diets: details matter. 2009 Obesity (Silver Spring) pmid:19553921
Figueras M et al. Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. 2011 Obesity (Silver Spring) pmid:20885391
Hargrave KM et al. Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice. 2002 Obes. Res. pmid:12490673
Thurmond DC et al. Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. 1993 Obes. Res. pmid:16353349
Miner JL et al. Conjugated linoleic acid (CLA), body fat, and apoptosis. 2001 Obes. Res. pmid:11316347
Hargrave KM et al. Influence of dietary conjugated linoleic Acid and fat source on body fat and apoptosis in mice. 2004 Obes. Res. pmid:15483208
Lasa A et al. Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. 2011 Nutrition pmid:20619605
Ghosh S et al. Role of dietary fatty acids and acute hyperglycemia in modulating cardiac cell death. 2004 Nutrition pmid:15474882
Jory J Abnormal fatty acids in Canadian children with autism. 2016 Nutrition pmid:26746679
Aronis A et al. Lipotoxic effects of triacylglycerols in J774.2 macrophages. 2008 Nutrition pmid:18165129
Rodríguez-Cruz M et al. Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. 2009 Nutrition pmid:18849148
Webb AN et al. Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. 2008 Nov-Dec Nutrition pmid:18619813
Burke PA et al. Conditionally essential fatty acid deficiencies in end-stage liver disease. 1999 Nutrition pmid:10319364
Fukushima M et al. Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on delta6-desaturase activity in the livers of rats fed a fat- and cholesterol-enriched diet. 1999 Nutrition pmid:10355850
Hilakivi-Clarke L et al. The influence of maternal diet on breast cancer risk among female offspring. 1999 Nutrition pmid:10355854
Yamasaki M et al. Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. 2003 Nutrition pmid:12507636
Cury-Boaventura MF et al. Comparative toxicity of oleic acid and linoleic acid on Raji cells. 2005 Nutrition pmid:15797684
Stark KD et al. Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil. 2002 Jul-Aug Nutrition pmid:12093443
Wolfe RR et al. Dietary fat composition alters pulmonary function in pigs. 2002 Jul-Aug Nutrition pmid:12093447
Rahman SM et al. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. 2001 Nutrition pmid:11377131
Moore CS et al. Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. 2006 Nutrition pmid:17027436
Kim KH and Park HS Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers. 2003 Nutrition pmid:12921888
Nagao K et al. The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. 2003 Jul-Aug Nutrition pmid:12831953
Decsi T and Koletzko B Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. 2000 Nutrition pmid:10869902
Peterson DB Long-chain fatty acids and cardiovascular disease risk in non-insulin-dependent diabetes. 1998 Nutrition pmid:9583379
Moran LJ et al. Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation. 2016 Nutrients pmid:26742065
Renner L et al. Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells. 2013 Nutrients pmid:23857174
Chilton FH et al. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. 2014 Nutrients pmid:24853887
Cerf ME and Herrera E High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. 2016 Nutrients pmid:26742067
Cinelli G et al. Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. 2016 Nutrients pmid:27314385