Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thomson AB et al. | A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. | 1987 | Am. J. Physiol. | pmid:3826353 |
| Murray MJ et al. | Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. | 1993 | Am. J. Physiol. | pmid:8279548 |
| Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
| West DB et al. | Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. | 1998 | Am. J. Physiol. | pmid:9728060 |
| Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
| Thomas ME et al. | Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. | 1995 | Am. J. Physiol. | pmid:7611458 |
| Chen ZY et al. | Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. | 1997 | Am. J. Physiol. | pmid:9038989 |
| WILSON JD | Relation between dietary cholesterol and bile acid excretion in the rat. | 1962 | Am. J. Physiol. | pmid:14001040 |
| Reddy SR et al. | Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. | 1989 | Am. J. Physiol. | pmid:2764141 |
| Le Petit-Thevenin J et al. | Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. | 1991 | Am. J. Physiol. | pmid:1887869 |
| Jayawickreme SP et al. | Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. | 1999 | Am. J. Physiol. | pmid:10198357 |
| DeLany JP et al. | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. | 1999 | Am. J. Physiol. | pmid:10198400 |
| Sebokova E et al. | Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. | 1988 | Am. J. Physiol. | pmid:2897795 |
| Delhanty PJ et al. | Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20587751 |
| Ross RA et al. | Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20647558 |
| López-Luna P et al. | Fate of orally administered radioactive fatty acids in the late-pregnant rat. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:26714850 |
| Henriksen EJ et al. | Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12618357 |
| Hodson L et al. | Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18940935 |
| Dailey MJ et al. | Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21917638 |
| Carpentier AC et al. | Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17062840 |
| Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
| Guo W et al. | Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17519282 |
| Payet MD et al. | An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells. | 2006 | Am. J. Physiol. Endocrinol. Metab. | pmid:16822961 |
| Subauste AR and Burant CF | Role of FoxO1 in FFA-induced oxidative stress in adipocytes. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17374693 |
| de Vogel-van den Bosch HM et al. | A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356535 |
| Kim EJ et al. | Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12121883 |
| Running CA and Mattes RD | Humans are more sensitive to the taste of linoleic and α-linolenic than oleic acid. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25540234 |
| Lukovac S et al. | Essential fatty acid deficiency in mice impairs lactose digestion. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18653724 |
| Mattes RD | Effects of linoleic acid on sweet, sour, salty, and bitter taste thresholds and intensity ratings of adults. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17290007 |
| Chalé-Rush A et al. | Multiple routes of chemosensitivity to free fatty acids in humans. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17234892 |
| Cho HJ et al. | Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12571082 |
| Friesen R and Innis SM | Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16282365 |
| Minich DM et al. | Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11093947 |
| Alzoghaibi MA et al. | Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14656710 |
| McHowat J and Creer MH | Selective plasmalogen substrate utilization by thrombin-stimulated Ca(2+)-independent PLA(2) in cardiomyocytes. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10843891 |
| Zaman MM et al. | Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20656894 |
| Mizuta K et al. | Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26342087 |
| Vij N | Linoleic acid supplement in cystic fibrosis: friend or foe? | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20709729 |
| Heeley EL et al. | Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666114 |
| Randich A et al. | Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14660477 |
| Whigham LD et al. | CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11171673 |
| Matravadia S et al. | LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition. | 2016 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26764053 |
| Pacini G et al. | Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19211728 |
| Bruder ED et al. | An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12689852 |
| Stratford JM and Contreras RJ | Saliva and other taste stimuli are important for gustatory processing of linoleic acid. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19692663 |
| RodrÃguez E et al. | Trans-10, cis-12, but not cis-9, trans-11 CLA isomer, inhibits brown adipocyte thermogenic capacity. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12010762 |
| Al-Khalifa A et al. | Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17122327 |
| Chen CS et al. | Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. | 2013 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24154509 |
| Whigham LD et al. | Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893615 |
| Darling RA et al. | Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24760994 |