Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Banni S et al. | Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | 2001 | Nutr Cancer | pmid:12094634 |
| Ealey KN et al. | Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats. | 2001 | Nutr Cancer | pmid:12094611 |
| Park HJ et al. | Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. | 2001 | Nutr Cancer | pmid:12094615 |
| Lasekan JB et al. | Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. | 1990 | Nutr Cancer | pmid:2106675 |
| Wang J et al. | Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. | 2008 | Nutr Cancer | pmid:18584483 |
| Ip C et al. | Control of rat mammary epithelium proliferation by conjugated linoleic acid. | 2001 | Nutr Cancer | pmid:11759286 |
| Yang H et al. | Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione. | 2001 | Nutr Cancer | pmid:11759290 |
| Mackie BS et al. | Melanoma and dietary lipids. | 1987 | Nutr Cancer | pmid:3110746 |
| Aro A et al. | Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. | 2000 | Nutr Cancer | pmid:11525591 |
| Kavanaugh CJ et al. | Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. | 1999 | Nutr Cancer | pmid:10368807 |
| De Stefani E et al. | Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. | 2006 | Nutr Cancer | pmid:17474860 |
| Berry EM et al. | Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. | 1987 | Nutr Cancer | pmid:3562291 |
| D'Angeli S et al. | Cold perception and gene expression differ in Olea europaea seed coat and embryo during drupe cold acclimation. | 2013 | New Phytol. | pmid:23078289 |
| Godinot N et al. | Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. | 2013 | Neuroscience | pmid:23831422 |
| Yamamoto S et al. | The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals. | 2005 | Neuroscience | pmid:15561436 |
| Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
| Pilitsis JG et al. | Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. | 2003 | Neurosci. Lett. | pmid:12946571 |
| Nakanishi T et al. | Dietary conjugated linoleic acid reduces cerebral prostaglandin E(2) in mice. | 2003 | Neurosci. Lett. | pmid:12686384 |
| Bourre JM et al. | Possible role of the choroid plexus in the supply of brain tissue with polyunsaturated fatty acids. | 1997 | Neurosci. Lett. | pmid:9132678 |
| Cao ZP et al. | Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP. | 2007 | Neurosci. Lett. | pmid:17466453 |
| Ziylan ZY et al. | Effect of dietary n-3 fatty acid deficiency on blood-to-brain transfer of sucrose, alpha-aminoisobutyric acid and phenylalanine in the rat. | 1992 | Neurosci. Lett. | pmid:1625821 |
| Yaguchi T et al. | Linoleic acid derivative DCP-LA improves learning impairment in SAMP8. | 2006 | Neuroreport | pmid:16361960 |
| Cox JE et al. | Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions. | 2001 | Neuroreport | pmid:11338171 |
| Aluf Y et al. | Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. | 2011 Jul-Aug | Neuropharmacology | pmid:21414328 |
| Lin HH et al. | Hormonal Modulation of Pheromone Detection Enhances Male Courtship Success. | 2016 | Neuron | pmid:27263969 |
| Dworkin RH et al. | Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. | 1984 | Neurology | pmid:6387534 |
| Li YC et al. | Effects of conjugated linoleic acid on cleavage of amyloid precursor protein via PPARγ. | 2011 | Neurol. Sci. | pmid:21800078 |
| Yehuda S et al. | Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. | 1998 | Neurochem. Res. | pmid:9566600 |
| Salvati S et al. | Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. | 2004 | Neurochem. Int. | pmid:14643750 |
| Kruska N and Reiser G | Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. | 2011 | Neurobiol. Dis. | pmid:21570468 |
| Huang X et al. | Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. | 2014 | Nephrol. Dial. Transplant. | pmid:23229929 |
| Kelavkar UP et al. | Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice. | 2004 Nov-Dec | Neoplasia | pmid:15720809 |
| Katan MB | [Linoleic acid and heart infarct]. | 2013 | Ned Tijdschr Geneeskd | pmid:23714298 |
| Romero MM et al. | The conjugated linoleic acid ester of estrone induces the mobilisation of fat in male Wistar rats. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17387456 |
| Ma C et al. | NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. | 2016 | Nature | pmid:26934227 |
| Itoh Y et al. | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. | 2003 | Nature | pmid:12629551 |
| Sarkar G | Beneficial ghee? | 1991 | Nature | pmid:1876181 |
| Chyb S et al. | Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. | 1999 | Nature | pmid:9930700 |
| Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
| Li Y et al. | Molecular recognition of nitrated fatty acids by PPAR gamma. | 2008 | Nat. Struct. Mol. Biol. | pmid:18604218 |
| Bentrad N et al. | Identification and evaluation of antibacterial agents present in lipophilic fractions isolated from sub-products of Phoenix dactilyfera. | 2017 | Nat. Prod. Res. | pmid:28403631 |
| Ozcan MM et al. | Characteristics of grape seed and oil from nine Turkish cultivars. | 2012 | Nat. Prod. Res. | pmid:22132714 |
| Patarra RF et al. | Fatty acid composition of selected macrophytes. | 2013 | Nat. Prod. Res. | pmid:22591127 |
| Saracoglu HT et al. | Evaluation of oil content and fatty acid composition of five endemic Bupleurum species growing in the Central Anatolia region of Turkey. | 2012 | Nat. Prod. Res. | pmid:21870933 |
| Beevi SS et al. | Polyphenolics profile and antioxidant properties of Raphanus sativus L. | 2012 | Nat. Prod. Res. | pmid:21714734 |
| Gören AC et al. | Fatty acid composition and chemotaxonomic evaluation of species of Stachys. | 2012 | Nat. Prod. Res. | pmid:21859257 |
| Bitis L et al. | Flavonoids and antioxidant activity of Rosa agrestis leaves. | 2010 | Nat. Prod. Res. | pmid:20397108 |
| Matthaus B and Özcan MM | Fatty acid and tocopherol contents of several soybean oils. | 2014 | Nat. Prod. Res. | pmid:24499198 |
| Xie J et al. | Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. | 2012 | Nat. Prod. Res. | pmid:21707231 |
| Tel-Çayan G et al. | A new fatty acid ester from an edible mushroom Rhizopogon luteolus. | 2016 | Nat. Prod. Res. | pmid:26987031 |