Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
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Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shimada Y et al. | Effects of Lentinus edodes on fatty acid and molecular species profiles of phosphatidylcholine in rats fed different levels of corn oil. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12353643 |
| Hornung E et al. | Formation of conjugated Delta11Delta13-double bonds by Delta12-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds. | 2002 | Eur. J. Biochem. | pmid:12354116 |
| Baumgard LH et al. | trans-10, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows. | 2002 | J. Dairy Sci. | pmid:12362447 |
| Peterson DG et al. | Analysis of variation in cis-9, trans-11 conjugated linoleic acid (CLA) in milk fat of dairy cows. | 2002 | J. Dairy Sci. | pmid:12362448 |
| AbuGhazaleh AA et al. | Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. | 2002 | J. Dairy Sci. | pmid:12362459 |
| Mashek DG et al. | Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. | 2002 | J. Dairy Sci. | pmid:12362461 |
| Hulbert AJ et al. | Acyl composition of muscle membranes varies with body size in birds. | 2002 | J. Exp. Biol. | pmid:12364409 |
| Korotkova M et al. | Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet. | 2002 | J. Lipid Res. | pmid:12364559 |
| Parmentier HK et al. | Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. | 2002 | Br. Poult. Sci. | pmid:12365510 |
| Belury MA | Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. | 2002 | J. Nutr. | pmid:12368384 |
| Gatlin LA et al. | Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality. | 2002 | J. Nutr. | pmid:12368402 |
| Reed DW et al. | Mechanism of 1,4-dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis. | 2002 | Eur. J. Biochem. | pmid:12383261 |
| Toyosaki T | Antioxidant effect of beta-carotene on lipid peroxidation and synergism with tocopherol in an emulsified linoleic acid model system. | 2002 | Int J Food Sci Nutr | pmid:12396467 |
| Freese R et al. | High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects. | 2002 | Am. J. Clin. Nutr. | pmid:12399265 |
| Petkova-Andonova M et al. | CYP92B1, A cytochrome P450, expressed in petunia flower buds, that catalyzes monooxidation of long-chain fatty acids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12400678 |
| Minemoto Y et al. | Oxidation of linoleic acid encapsulated with soluble soybean polysaccharide by spray-drying. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12400679 |
| Yamasaki M et al. | Potent cytotoxic effect of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells. | 2002 | Cancer Lett. | pmid:12406562 |
| Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
| Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
| RamÃrez-Expósito MJ et al. | Effects of exogenous fatty acids and cholesterol on aminopeptidase activities in rat astroglia. | 2002 | Cell Biochem. Funct. | pmid:12415561 |
| da Costa M et al. | Incorporation of [1-14C]-linoleic acid by LLC-WRC256 tumour cells. | 2002 | Cell Biochem. Funct. | pmid:12415566 |
| Perfield JW et al. | Effects of dietary supplementation of rumen-protected conjugated linoleic acid in dairy cows during established lactation. | 2002 | J. Dairy Sci. | pmid:12416815 |
| Lee JY and Hwang DH | Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12419306 |
| Demaree SR et al. | Conjugated linoleic acid differentially modifies fatty acid composition in subcellular fractions of muscle and adipose tissue but not adiposity of postweaning pigs. | 2002 | J. Nutr. | pmid:12421839 |
| Craven J et al. | Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs? | 2002 | J. Vet. Pharmacol. Ther. | pmid:12423225 |
| Grechkin AN et al. | Role of structure and pH in cyclization of allene oxide fatty acids: implications for the reaction mechanism. | 2002 | Chem. Phys. Lipids | pmid:12426078 |
| Cardador-MartÃnez A et al. | Antioxidant activity in common beans (Phaseolus vulgaris L.). | 2002 | J. Agric. Food Chem. | pmid:12428946 |
| Takahashi Y et al. | Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. | 2002 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12431407 |
| Ridsdill-Smith J et al. | Induced responses in clover to an herbaceous mite. | 2002 | Arch. Insect Biochem. Physiol. | pmid:12432518 |
| Taylor LJ et al. | Effect of occlusion on the percutaneous penetration of linoleic acid and glycerol. | 2002 | Int J Pharm | pmid:12433444 |
| Belury M | Not all trans-fatty acids are alike: what consumers may lose when we oversimplify nutrition facts. | 2002 | J Am Diet Assoc | pmid:12449281 |
| Kishino S et al. | Ricinoleic acid and castor oil as substrates for conjugated linoleic acid production by washed cells of Lactobacillus plantarum. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12450151 |
| Rosa A et al. | Antioxidant activity of capsinoids. | 2002 | J. Agric. Food Chem. | pmid:12452665 |
| Tischendorf F et al. | Effect of dietary conjugated linoleic acids on the distribution of fatty acids in serum lipoprotein fractions and different tissues of growing pigs. | 2002 | J Anim Physiol Anim Nutr (Berl) | pmid:12452973 |
| Makristathis A et al. | Fatty acid composition and preservation of the Tyrolean Iceman and other mummies. | 2002 | J. Lipid Res. | pmid:12454266 |
| Demizieux L et al. | Conjugated linoleic acid isomers in mitochondria: evidence for an alteration of fatty acid oxidation. | 2002 | J. Lipid Res. | pmid:12454273 |
| Higashi-Okai K et al. | Potent suppressive activity of fresh and dried peels from Satsuma mandarin Citrus unshiu (Marcorv.) on hydroperoxide generation from oxidized linoleic acid. | 2002 | Phytother Res | pmid:12458489 |
| Mir PS et al. | Growth, carcass characteristics, muscle conjugated linoleic acid (CLA) content, and response to intravenous glucose challenge in high percentage Wagyu, Wagyu x Limousin, and Limousin steers fed sunflower oil-containing diet. | 2002 | J. Anim. Sci. | pmid:12462269 |
| Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
| Rainio A et al. | Cell-adhered conjugated linoleic acid regulates isomerization of linoleic acid by resting cells of Propionibacterium freudenreichii. | 2002 | Appl. Microbiol. Biotechnol. | pmid:12466891 |
| Iwakiri Y et al. | Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by conjugated linoleic acid in murine macrophages. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468265 |
| Bassaganya-Riera J et al. | Colonic anti-inflammatory mechanisms of conjugated linoleic acid. | 2002 | Clin Nutr | pmid:12468364 |
| Zhang Y et al. | Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. | 2002 | J. Agric. Food Chem. | pmid:12475274 |
| Cooper DJ et al. | Role of beer lipid-binding proteins in preventing lipid destabilization of foam. | 2002 | J. Agric. Food Chem. | pmid:12475284 |
| Kristinsson HG | Acid-induced unfolding of flounder hemoglobin: evidence for a molten globular state with enhanced pro-oxidative activity. | 2002 | J. Agric. Food Chem. | pmid:12475287 |
| Hargrave KM et al. | Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice. | 2002 | Obes. Res. | pmid:12490673 |
| French MA et al. | Cholesterolaemic effect of palmitic acid in relation to other dietary fatty acids. | 2002 | Asia Pac J Clin Nutr | pmid:12492626 |
| Coakley M et al. | Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species. | 2003 | J. Appl. Microbiol. | pmid:12492934 |
| Ostrowska E et al. | Effects of dietary fat and conjugated linoleic acid on plasma metabolite concentrations and metabolic responses to homeostatic signals in pigs. | 2002 | Br. J. Nutr. | pmid:12493084 |
| Wachira AM et al. | Effects of dietary fat source and breed on the carcass composition, n-3 polyunsaturated fatty acid and conjugated linoleic acid content of sheep meat and adipose tissue. | 2002 | Br. J. Nutr. | pmid:12493092 |