Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
Badwey JA et al. | Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. | 1984 | J. Biol. Chem. | pmid:6330088 |
Manku MS et al. | Essential fatty acids in the plasma phospholipids of patients with atopic eczema. | 1984 | Br. J. Dermatol. | pmid:6329254 |
Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |
Simon I et al. | Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6326852 |
Kitagawa S et al. | Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6324876 |
Spector AA et al. | Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells. | 1983 | J. Lipid Res. | pmid:6321621 |
Nicholson T and Omer SA | The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. | 1983 | Zentralbl Veterinarmed A | pmid:6318476 |
Baba A et al. | Modulation by unsaturated fatty acids of norepinephrine- and adenosine-induced formation of cyclic AMP in brain slices. | 1984 | J. Neurochem. | pmid:6315886 |
Kirstein D et al. | Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. | 1983 | Br. J. Nutr. | pmid:6315055 |
Byrne WJ | Intralipid or Liposyn--comparable products? | 1982 | J. Pediatr. Gastroenterol. Nutr. | pmid:6310073 |
Sanders TA | Dietary fat and platelet function. | 1983 | Clin. Sci. | pmid:6309463 |
Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
Oliw EH | Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6301473 |
Rosenthal MD and Whitehurst MC | Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. | 1983 | Biochim. Biophys. Acta | pmid:6297606 |
Shechter Y et al. | Evaluation of factors responsible for the inability of insulin to antagonize lipolysis due to high concentrations of catecholamines. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6297490 |
Ookhtens M and Baker N | Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. | 1983 | Am. J. Physiol. | pmid:6295191 |
Rosenthal MD and Whitehurst MC | Selective utilization of omega 6 and omega 3 polyunsaturated fatty acids by human skin fibroblasts. | 1982 | J. Cell. Physiol. | pmid:6294123 |
Thomas MJ et al. | The role of superoxide in xanthine oxidase-induced autooxidation of linoleic acid. | 1982 | J. Biol. Chem. | pmid:6282880 |
Sutherland MW and Gebicki JM | A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles. | 1982 | Arch. Biochem. Biophys. | pmid:6282219 |
De Schrijver R and Privett OS | Effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. | 1982 | J. Nutr. | pmid:6279803 |
Huang YS et al. | Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). | 1982 | Atherosclerosis | pmid:6279122 |
Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
Gavigan SJ and Knight BL | Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids. | 1981 | Biochim. Biophys. Acta | pmid:6271233 |
Benaim G et al. | Different conformational states of the purified Ca2+-ATPase of the erythrocyte plasma membrane revealed by controlled trypsin proteolysis. | 1984 | J. Biol. Chem. | pmid:6234313 |
Breton M et al. | Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6230079 |
Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
Hoover RL et al. | Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes. | 1983 | J. Cell Biol. | pmid:6223042 |
Mitranic MM et al. | The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. | 1982 | Biochim. Biophys. Acta | pmid:6217837 |
Van Alstine JM and Brooks DE | Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. | 1984 | Clin. Chem. | pmid:6199135 |
Goldmacher VS | Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. | 1983 | Biochem. Pharmacol. | pmid:6189496 |
Wood DA et al. | Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. | 1984 | Lancet | pmid:6146032 |
Gerzer R et al. | Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6134818 |
Enser M and Roberts JL | The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. | 1982 | Biochem. J. | pmid:6128973 |
Hoelgaard A and Møllgaard B | Permeation of linoleic acid through skin in vitro. | 1982 | J. Pharm. Pharmacol. | pmid:6127396 |
Cheah AM | Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. | 1981 | Biochim. Biophys. Acta | pmid:6118177 |
Volpe JJ and Obert KA | Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. | 1981 | Arch. Biochem. Biophys. | pmid:6118099 |
Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
Chen TC et al. | Modulation of 1,25-dihydroxyvitamin D3 receptor by phospholipids and fatty acids. | 1984 | J. Lipid Res. | pmid:6099395 |
Codde JP et al. | Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. | 1984 | J. Hypertens. | pmid:6099384 |
Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |
Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
Curnutte JT et al. | Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. | 1984 | J. Biol. Chem. | pmid:6090448 |
Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
Kabara JJ et al. | Fatty acids and derivatives as antimicrobial agents. | 1972 | Antimicrob. Agents Chemother. | pmid:4670656 |
Giamalva D et al. | A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084297 |
Clark DL and Queener SF | Effects of diabetes mellitus on renal fatty acid activation and desaturation. | 1985 | Biochem. Pharmacol. | pmid:4074391 |
Potter LM and McCarthy JP | Varying fat and protein in diets of growing large white turkeys. | 1985 | Poult. Sci. | pmid:4070128 |
Barclay LR et al. | The antioxidant activity of alpha-tocopherol-bovine serum albumin complex in micellar and liposome autoxidations. | 1985 | J. Biol. Chem. | pmid:4066696 |