Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kageyama K et al. | Synergistic inhibition of DNA synthesis in Ehrlich ascites tumour cells by a combination of unsaturated fatty acids and hyperthermia. | 1989 | J Appl Toxicol | pmid:2926093 |
| Booker ML et al. | Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog. | 1989 | Gastroenterology | pmid:2507386 |
| Garcia Zevallos M and Farkas T | Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. | 1989 | Arch. Biochem. Biophys. | pmid:2786374 |
| Glatz JF et al. | Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. | 1989 | Am. J. Clin. Nutr. | pmid:2916448 |
| Bernbäck S et al. | Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. | 1989 | Biochim. Biophys. Acta | pmid:2917153 |
| Hubbard NE and Erickson KL | Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases. | 1989 | Cancer Lett. | pmid:2920371 |
| Tchervenkov JI et al. | The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival. | 1989 | Transplantation | pmid:2643225 |
| Bourre JM et al. | The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. | 1989 | J. Nutr. | pmid:2576038 |
| Fairbank J et al. | Octadeca-9,11-dienoic acid in cervical intraepithelial neoplasia: a colposcopic study. | 1989 | Clin. Chim. Acta | pmid:2612010 |
| Park JH et al. | Effects of dietary linoleic acid on mucosal adaptation after small bowel resection. | 1989 | Digestion | pmid:2612750 |
| Meikle AW et al. | Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. | 1989 | Am. J. Physiol. | pmid:2558577 |
| Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
| Gardner HW | Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. | 1989 | Biochim. Biophys. Acta | pmid:2492826 |
| Hamazaki S et al. | Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. | 1989 | Arch. Biochem. Biophys. | pmid:2500058 |
| Imaizumi K et al. | Effect of phosphatidylethanolamine and its constituent base on the metabolism of linoleic acid in rat liver. | 1989 | Biochim. Biophys. Acta | pmid:2508745 |
| Hicks M et al. | Increase in crosslinking of nonenzymatically glycosylated collagen induced by products of lipid peroxidation. | 1989 | Arch. Biochem. Biophys. | pmid:2492180 |
| Hansen O | Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. | 1989 | Biochim. Biophys. Acta | pmid:2554979 |
| Stammers JP et al. | High arachidonic acid levels in the cord blood of infants of mothers on vegetarian diets. | 1989 | Br. J. Nutr. | pmid:2493804 |
| Blond JP et al. | Effect of fenofibrate treatment on linoleic acid desaturation in liver of obese Zucker rats. | 1989 | Biochem. Pharmacol. | pmid:2764996 |
| Braughler JM and Pregenzer JF | The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. | 1989 | Free Radic. Biol. Med. | pmid:2806938 |
| Hrelia S et al. | Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2570573 |
| Bolton-Smith C et al. | The effect of dietary linoleic acid on rat platelet sialic acid. | 1989 | Biochim. Biophys. Acta | pmid:2775771 |
| Blanken R et al. | Effect of mineral oil and linoleic-acid-containing emulsions on the skin vapour loss of sodium-lauryl-sulphate-induced irritant skin reactions. | 1989 | Contact Derm. | pmid:2706971 |
| Levay-Young BK and Nandi S | Spermidine is necessary for, but not the only mediator of, linoleic acid-stimulated alpha-casein accumulation in mouse mammary epithelial cells. | 1989 | Endocrinology | pmid:2759031 |
| Reddy SR et al. | Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. | 1989 | Am. J. Physiol. | pmid:2764141 |
| Cunnane SC et al. | Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. | 1989 | Am. J. Clin. Nutr. | pmid:2801584 |
| Rose DP and Connolly JM | Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803300 |
| Mahfouz MM et al. | Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. | 1989 | Biochim. Biophys. Acta | pmid:2804072 |
| Klein A et al. | The effect of fatty acids on the vulnerability of lymphocytes to cortisol. | 1989 | Metab. Clin. Exp. | pmid:2537454 |
| Christon R et al. | Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. | 1989 | Biochim. Biophys. Acta | pmid:2538158 |
| Chen Q et al. | Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. | 1989 | Biochim. Biophys. Acta | pmid:2503032 |
| Shires SE et al. | Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. | 1989 | Biochim. Biophys. Acta | pmid:2493807 |
| Diehl AK et al. | Dietary intake and the prevalence of gallbladder disease in Mexican Americans. | 1989 | Gastroenterology | pmid:2583417 |
| Szamel M et al. | Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. | 1989 | J. Immunol. | pmid:2530278 |
| Schneider YJ | Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium. | 1989 | J. Immunol. Methods | pmid:2644356 |
| Watkins BA | Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. | 1989 | Br. J. Nutr. | pmid:2923859 |
| Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
| Ha YL et al. | Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. | 1990 | Cancer Res. | pmid:2297758 |
| Kawahara J et al. | Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. | 1990 | Hypertension | pmid:2298478 |
| Lefkowith J et al. | Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. | 1990 | J. Exp. Med. | pmid:2307932 |
| Buckman DK et al. | Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. | 1990 | J. Nutr. | pmid:2313378 |
| Katzenellenbogen BS and Norman MJ | Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. | 1990 | Endocrinology | pmid:2404751 |
| Kinsella JE and Lokesh B | Dietary lipids, eicosanoids, and the immune system. | 1990 | Crit. Care Med. | pmid:2105185 |
| Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
| Conquer J and Mahadevappa VG | Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2106881 |
| Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
| Ando H et al. | Protein kinase C and linoleic acid-induced inhibition of melanogenesis. | 1990 | Pigment Cell Res. | pmid:2077533 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |