Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Nakagawa Y | [Metabolism and biological function of cardiolipin]. | 2013 | Yakugaku Zasshi | pmid:23649397 |
Fujii M | Pathogenesis of Diet-induced Atopic Dermatitis in Hairless Mice. | 2017 | Yakugaku Zasshi | pmid:28049895 |
Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
Cardoso CR et al. | Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. | 2004 Mar-Apr | Wound Repair Regen | pmid:15086775 |
Simopoulos AP | Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. | 2009 | World Rev Nutr Diet | pmid:19696523 |
Ramsden CE et al. | All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. | 2011 | World Rev Nutr Diet | pmid:21865817 |
Okuyama H et al. | Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. | 2007 | World Rev Nutr Diet | pmid:17167282 |
Okuyama H et al. | Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? | 2007 | World Rev Nutr Diet | pmid:17167283 |
Okuyama H et al. | Mechanisms by which dietary fats affect coronary heart disease mortality. | 2007 | World Rev Nutr Diet | pmid:17167284 |
Okuyama H et al. | Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. | 2007 | World Rev Nutr Diet | pmid:17167285 |