Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Iwase H et al. | Effect of cytochrome c on the linoleic acid-degrading activity of porcine leukocyte 12-lipoxygenase. | 2000 | Free Radic. Biol. Med. | pmid:10802222 |
Gupta SV and Khosla P | Pork fat and chicken fat similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. | 2000 | J. Nutr. | pmid:10801922 |
Itokazu N et al. | Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. | 2000 | Brain Res. | pmid:10799687 |
Kaya A | Properties and stability of butter oil obtained from milk and yoghurt. | 2000 | Nahrung | pmid:10795582 |
Mandin O et al. | Volatile compounds from potato-like model systems. | 1999 | J. Agric. Food Chem. | pmid:10794636 |
McEvoy TG et al. | Fatty acid composition of lipids in immature cattle, pig and sheep oocytes with intact zona pellucida. | 2000 | J. Reprod. Fertil. | pmid:10793638 |
McCarty MF | Toward a wholly nutritional therapy for type 2 diabetes. | 2000 | Med. Hypotheses | pmid:10783493 |
Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
Hover CG and Kulkarni AP | A simple and efficient method for hemoglobin removal from mammalian tissue cytosol by zinc sulfate and its application to the study of lipoxygenase. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780874 |
Talcott ST et al. | Antioxidant changes and sensory properties of carrot puree processed with and without periderm tissue. | 2000 | J. Agric. Food Chem. | pmid:10775391 |
Liégeois C et al. | Measuring antioxidant efficiency of wort, malt, and hops against the 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidation of an aqueous dispersion of linoleic acid. | 2000 | J. Agric. Food Chem. | pmid:10775361 |
Sasaki T et al. | Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood. | 2000 | J. Agric. Food Chem. | pmid:10775347 |
Siefken W et al. | Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes. | 2000 | Exp. Dermatol. | pmid:10772388 |
Kritharides L | Ascorbic acid and copper in linoleate oxidation--Dunkley revisited. | 1999 | Redox Rep. | pmid:10772064 |
Mogul R et al. | Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. | 2000 | Biochemistry | pmid:10769137 |
Littman ED et al. | Role of protein kinase C isoenzymes in fatty acid stimulation of insulin secretion. | 2000 | Pancreas | pmid:10766451 |
Mohan IK and Das UN | Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765977 |
Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
Hubbard NE et al. | Reduction of murine mammary tumor metastasis by conjugated linoleic acid. | 2000 | Cancer Lett. | pmid:10755392 |
Trimborn M et al. | Linoleic acid cytotoxicity to bovine lens epithelial cells: influence of albumin on linoleic acid uptake and cytotoxicity. | 2000 Mar-Jun | Ophthalmic Res. | pmid:10754440 |