Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jenkins TC et al. | Dietary soybean oil changes lipolytic rate and composition of fatty acids in plasma membranes of ovine adipocytes. | 1994 | J. Nutr. | pmid:8145079 |
| JAGANNATHAN SN | Effect of feeding different fat mixtures providing the same amount of linoleic acid, on serum cholesterol levels in monkeys and liver cholesterol concentration in cholesterol-fed rats. | 1962 | J. Nutr. | pmid:14450883 |
| JAGANNATHAN SN | Effect of feeding fat blends of hydrogenated groundnut (peanut) fat and cottonseed oil containing different levels of linoleic acid on serum choles terol levels in monkeys (Macaca radiata) and liver cholesterol concentration in cholesterol-fed rats. | 1962 | J. Nutr. | pmid:14450884 |
| Kinter M et al. | Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity. | 1996 | J. Nutr. | pmid:9001361 |
| Sisk MB et al. | Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. | 2001 | J. Nutr. | pmid:11385051 |
| Misikangas M et al. | High linoleic acid, low vegetable, and high oleic acid, high vegetable diets affect platelet activation similarly in healthy women and men. | 2001 | J. Nutr. | pmid:11385056 |
| Baumgard LH et al. | Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). | 2001 | J. Nutr. | pmid:11385065 |
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| Peterson DG et al. | Diet-induced milk fat depression in dairy cows results in increased trans-10, cis-12 CLA in milk fat and coordinate suppression of mRNA abundance for mammary enzymes involved in milk fat synthesis. | 2003 | J. Nutr. | pmid:14519791 |
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| Yamasaki M et al. | Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. | 2003 | J. Nutr. | pmid:12612153 |
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| Hontecillas R et al. | Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. | 2002 | J. Nutr. | pmid:12097686 |
| Kimura Y | Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. | 2002 | J. Nutr. | pmid:12097695 |
| Han SN et al. | Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. | 2012 | J. Nutr. | pmid:23096013 |
| WALKER BL and KUMMEROW FA | DIETARY FAT AND THE STRUCTURE AND PROPERTIES OF RAT ERYTHROCYTES. III. RESPONSE OF ERYTHROCYTE FATTY ACIDS TO VARIOUS DIETARY FATS. | 1964 | J. Nutr. | pmid:14133362 |
| Eder K and Kirchgessner M | Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. | 1994 | J. Nutr. | pmid:7931700 |
| Raes K et al. | The deposition of conjugated linoleic acids in eggs of laying hens fed diets varying in fat level and fatty acid profile. | 2002 | J. Nutr. | pmid:11823576 |
| WOOD RD et al. | Metabolism of labeled linoleic-1-C-14 acid in the sheep rumen. | 1963 | J. Nutr. | pmid:14001756 |
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| Becker W | Distribution of 14C after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. | 1984 | J. Nutr. | pmid:6470826 |
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| Gatlin LA et al. | Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality. | 2002 | J. Nutr. | pmid:12368402 |
| Hall JA et al. | The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs. | 2006 | J. Nutr. | pmid:16920851 |
| Awad AB and Chattopadhyay JP | Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase of rat adipocytes. | 1986 | J. Nutr. | pmid:3723204 |
| Liou YA et al. | Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. | 2007 | J. Nutr. | pmid:17374659 |
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| Azain MJ et al. | Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. | 2000 | J. Nutr. | pmid:10827208 |
| Bell JG et al. | High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. | 1991 | J. Nutr. | pmid:1861166 |
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| Reiterer G et al. | Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. | 2004 | J. Nutr. | pmid:15051824 |
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| Mimoun M et al. | Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. | 2009 | J. Nutr. | pmid:19828687 |
| Kabagambe EK et al. | The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in costa rica. | 2005 | J. Nutr. | pmid:16251629 |
| Wickwire MA et al. | Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. | 1987 | J. Nutr. | pmid:3470441 |
| LYMAN RL et al. | LIVER LIPID ACCUMULATION IN ISOLEUCINE-DEFICIENT RATS. | 1964 | J. Nutr. | pmid:14151129 |
| Bee G | Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs. | 2000 | J. Nutr. | pmid:11110857 |
| Takahashi R et al. | Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. | 1987 | J. Nutr. | pmid:2888839 |
| WOODALL AN et al. | NUTRITION OF SALMONOID FISHES. 13. THE ALPHA-TOCOPHEROL REQUIREMENT OF CHINOOK SALMON. | 1964 | J. Nutr. | pmid:14236910 |
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