Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Horan KL et al. | Kinetic evaluation of lipophilic inhibitors of lipid peroxidation in DLPC liposomes. | 1994 | Free Radic. Biol. Med. | pmid:7867975 |
Pawlosky R et al. | Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:7868981 |
Boissonneault GA et al. | Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:7872651 |
Decsi T and Koletzko B | Do trans fatty acids impair linoleic acid metabolism in children? | 1995 | Ann. Nutr. Metab. | pmid:7872654 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Bellavite P et al. | Correlations between the intensity of fMLP-dependent respiratory burst and cellular fatty acid composition in human neutrophils. | 1995 | Br. J. Haematol. | pmid:7873377 |
Fushiki T et al. | Swimming endurance capacity of mice is increased by chronic consumption of medium-chain triglycerides. | 1995 | J. Nutr. | pmid:7876928 |
Yu WK and Wells PG | Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7878664 |
Kim C et al. | A comprehensive evaluation of the vial equilibration method for quantification of the metabolism of volatile organic chemicals. Trichloroethylene. | 1994 Nov-Dec | Drug Metab. Dispos. | pmid:7895602 |
Keshavarz K | Further investigations on the effect of dietary manipulations of nutrients on early egg weight. | 1995 | Poult. Sci. | pmid:7899214 |
Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
Leichsenring M et al. | Scaly skin alterations and plasma fatty acids in Congolese children. | 1993 | Acta Trop. | pmid:7902652 |
Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
Regdel D et al. | On the reaction specificity of the lipoxygenase from tomato fruits. | 1994 | Biochim. Biophys. Acta | pmid:7905748 |
Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
Emken EA et al. | Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. | 1994 | Biochim. Biophys. Acta | pmid:7914092 |
Yang J et al. | Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. | 1994 | Metab. Clin. Exp. | pmid:7914345 |
Sacks GS et al. | Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. | 1994 May-Jun | JPEN J Parenter Enteral Nutr | pmid:7914941 |
Ulmann L et al. | Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7915142 |
Watanabe S et al. | A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. | 1994 | J. Nutr. | pmid:7916376 |
van Kuiken BA and Behnke WD | The activation of porcine pancreatic lipase by cis-unsaturated fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7918595 |
Roy P et al. | Superoxide generation by lipoxygenase in the presence of NADH and NADPH. | 1994 | Biochim. Biophys. Acta | pmid:7918597 |
Bakken AM et al. | The activities of acyl-CoA hydrolase in lysate and subcellular fractions of human blood platelets in relation to activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase. | 1994 | Biochim. Biophys. Acta | pmid:7918598 |
del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
Eder K and Kirchgessner M | Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. | 1994 | J. Nutr. | pmid:7931700 |
Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
Pronczuk A et al. | Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils. | 1994 | FASEB J. | pmid:7958627 |
Hopewell JW et al. | Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. | 1994 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:7961020 |
Gibson RA et al. | Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. | 1994 | J. Pediatr. | pmid:7965453 |
Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
Soltysova T and Bellisle F | Nutrition in ten-year-old children of the Liberec area (Czech Republic). | 1994 | Ann. Nutr. Metab. | pmid:7979168 |
Ohrvall M et al. | Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. | 1994 | Atherosclerosis | pmid:7980703 |
Lee KN et al. | Conjugated linoleic acid and atherosclerosis in rabbits. | 1994 | Atherosclerosis | pmid:7980704 |
Yam D et al. | Insulin and glucose status, tissue and plasma lipids in patients with tumours of the ovary or endometrium: possible dietary implications. | 1994 | Br. J. Cancer | pmid:7981074 |
Kasayama S et al. | Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins. | 1994 | Cancer Res. | pmid:7987840 |
Rose DP et al. | Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro. | 1994 | Cancer Res. | pmid:7987856 |
Pourplanche C et al. | Conformational changes of lipoxygenase (LOX) in modified environments. Contribution to the variation in specificity of soybean LOX type 1. | 1994 | J. Biol. Chem. | pmid:7989328 |
Babizhayev MA et al. | L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. | 1994 | Biochem. J. | pmid:7998987 |
Carpenter KL et al. | Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. | 1994 | Biochem. J. | pmid:7999000 |
Lafond J et al. | Linoleic acid transport by human placental syncytiotrophoblast membranes. | 1994 | Eur. J. Biochem. | pmid:8001588 |
Simopoulos AP | Is insulin resistance influenced by dietary linoleic acid and trans fatty acids? | 1994 | Free Radic. Biol. Med. | pmid:8001841 |
Jack CI et al. | Serum octadeca-9,11 dienoic acid--an assay of free radical activity or a result of bacterial production? | 1994 | Clin. Chim. Acta | pmid:8004784 |
Nowak D et al. | Antioxidant properties of Ambroxol. | 1994 | Free Radic. Biol. Med. | pmid:8005537 |
Luthria DL and Sprecher H | A comparison of the specific activities of linoleate and arachidonate in liver, heart and kidney phospholipids after feeding rats ethyl linoleate-9,10,12,13-d4. | 1994 | Biochim. Biophys. Acta | pmid:8011670 |
Woldseth B and Christophersen BO | Biosynthesis of phospholipid molecular species in isolated liver cells studied by combining fatty acid substrates esterified in the sn-1 and sn-2 positions. | 1994 | Biochim. Biophys. Acta | pmid:8011678 |
Hussey HJ and Tisdale MJ | Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo. | 1994 | Br. J. Cancer | pmid:8018542 |
Loidl-Stahlhofen A et al. | Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. | 1994 | Biochim. Biophys. Acta | pmid:8025124 |
Kaufman MJ | Comparison of the free radical-scavenging ability of captopril and ascorbic acid in an in-vitro model of lipid oxidation. Implications for reperfusion injury and ACE inhibitor therapy. | 1994 | J. Pharm. Pharmacol. | pmid:8027931 |
Batna A and Spiteller G | Oxidation of furan fatty acids by soybean lipoxygenase-1 in the presence of linoleic acid. | 1994 | Chem. Phys. Lipids | pmid:8033289 |
Imokawa G et al. | Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia. | 1994 | J. Clin. Invest. | pmid:8040295 |
Kliewer SA et al. | Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8041794 |
Grabski S et al. | Lipids trigger changes in the elasticity of the cytoskeleton in plant cells: a cell optical displacement assay for live cell measurements. | 1994 | J. Cell Biol. | pmid:8045935 |
Hoving EB et al. | Gestational age dependency of essential fatty acids in cord plasma cholesterol esters and triglycerides. | 1994 | Pediatr. Res. | pmid:8047383 |
Siguel EN and Lerman RH | Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. | 1994 | Metab. Clin. Exp. | pmid:8052156 |
Jensen MM et al. | Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. | 1994 | Ann. Nutr. Metab. | pmid:8067685 |
Denizot Y et al. | Stimulated human gastric tumor cells (HGT) fail to synthesize eicosanoids. | 1994 | Cancer Lett. | pmid:8076375 |
Nakashima Y et al. | Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. | 1993 | J. Lipid Res. | pmid:8094090 |
Asaoka Y et al. | Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8099446 |
Shichiri G et al. | Polyunsaturated fatty acid metabolism and acetylated low density lipoprotein uptake in J774A.1 cells. | 1993 | Arch. Biochem. Biophys. | pmid:8099780 |
Spady DK | Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat. | 1993 | J. Lipid Res. | pmid:8105015 |
DeWille JW and Farmer SJ | Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels. | 1993 | Biochim. Biophys. Acta | pmid:8105893 |
Hamberg M et al. | Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. | 1994 | Arch. Biochem. Biophys. | pmid:8117115 |
Loidl-Stahlhofen A and Spiteller G | alpha-Hydroxyaldehydes, products of lipid peroxidation. | 1994 | Biochim. Biophys. Acta | pmid:8117742 |
Hernández-Muñoz I et al. | Toxic oil stimulates collagen synthesis acting at a pretranslational level in cultured fat-storing cells. | 1994 | Gastroenterology | pmid:8119541 |
Schürer NY et al. | Evidence for a novel keratinocyte fatty acid uptake mechanism with preference for linoleic acid: comparison of oleic and linoleic acid uptake by cultured human keratinocytes, fibroblasts and a human hepatoma cell line. | 1994 | Biochim. Biophys. Acta | pmid:8123682 |
Liu XH and Rose DP | Stimulation of type IV collagenase expression by linoleic acid in a metastatic human breast cancer cell line. | 1994 | Cancer Lett. | pmid:8124668 |
Rao SI et al. | The lipoxygenase activity of myoglobin. Oxidation of linoleic acid by the ferryl oxygen rather than protein radical. | 1994 | J. Biol. Chem. | pmid:8125933 |
Castell JV et al. | Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid. | 1994 | Photochem. Photobiol. | pmid:8127938 |
Chopra M et al. | Free radical scavenging of lutein in vitro. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8129303 |
Ip C et al. | Potential of food modification in cancer prevention. | 1994 | Cancer Res. | pmid:8137319 |
Calder PC et al. | Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols on lymphocyte proliferation. | 1994 | Biochem. J. | pmid:8141773 |
Shiina T et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. | 1993 | Atherosclerosis | pmid:8141854 |
Paiement J et al. | Modulation of GTP-dependent fusion by linoleic and arachidonic acid in derivatives of rough endoplasmic reticulum from rat liver. | 1994 | Biochim. Biophys. Acta | pmid:8142417 |
Jenkins TC et al. | Dietary soybean oil changes lipolytic rate and composition of fatty acids in plasma membranes of ovine adipocytes. | 1994 | J. Nutr. | pmid:8145079 |
Reaven PD et al. | Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. | 1994 | Arterioscler. Thromb. | pmid:8148354 |
Kanekal S and Kehrer JP | Metabolism of cyclophosphamide by lipoxygenases. | 1994 Jan-Feb | Drug Metab. Dispos. | pmid:8149893 |
Araki K et al. | Reduced cytotoxicity of a root canal sealer through eugenol substitution. | 1993 | J Endod | pmid:8151243 |
Fuchs GJ et al. | Effect of dietary fat on cardiovascular risk factors in infancy. | 1994 | Pediatrics | pmid:8165074 |
Cho Y and Ziboh VA | Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. | 1994 | J. Lipid Res. | pmid:8169529 |
Appel MJ et al. | Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters. | 1994 | Cancer Res. | pmid:8174115 |
Jakobsen K et al. | Heat production and quantitative oxidation of nutrients by physical activity in pigs. | 1994 | Ann. Nutr. Metab. | pmid:8185282 |
Belluzzi A et al. | Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186338 |
Cronan JE and Rock CO | The presence of linoleic acid in Escherichia coli cannot be confirmed. | 1994 | J. Bacteriol. | pmid:8188608 |
Hodgson JM et al. | Can linoleic acid contribute to coronary artery disease? | 1993 | Am. J. Clin. Nutr. | pmid:8192728 |
Truswell AS | Can linoleic acid contribute to coronary artery disease? | 1994 | Am. J. Clin. Nutr. | pmid:8198070 |
Andrassy RJ et al. | Linoleic acid enhances mitogen response and survival of septic weanling rats. | 1994 | J. Pediatr. Surg. | pmid:8201499 |
Yamashiro Y et al. | Effects of ursodeoxycholic acid treatment on essential fatty acid deficiency in patients with biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:8201513 |
Glasgow WC and Eling TE | Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8203891 |
Grammatopoulos D et al. | The human myometrial CRH receptor: G proteins and second messengers. | 1994 | Mol. Cell. Endocrinol. | pmid:8206332 |
Sakuma S et al. | Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. | 1993 | Prostaglandins | pmid:8210445 |
Viscardi RM and Max SR | Unsaturated fatty acid modulation of glucocorticoid receptor binding in L2 cells. | 1993 | Steroids | pmid:8212085 |
de Deckere EA et al. | Hepatic de novo fatty acid synthesis in the rat. | 1993 | Ann. Nutr. Metab. | pmid:8215236 |
Daret D et al. | Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production. | 1993 | J. Lipid Res. | pmid:8228632 |
Markovic DZ and Patterson LK | Benzophenone-sensitized lipid peroxidation in linoleate micelles. | 1993 | Photochem. Photobiol. | pmid:8234464 |
Biagi PL et al. | Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. | 1993 | Acta Paediatr. | pmid:8241678 |
Darmani H et al. | Interferon-gamma-stimulated uptake and turnover of linoleate and arachidonate in macrophages: a possible pathway for hypersensitivity to endotoxin. | 1993 | Cell. Immunol. | pmid:8242772 |