Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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WITTELS B and BRESSLER R | BIOCHEMICAL LESION OF DIPHTHERIA TOXIN IN THE HEART. | 1964 | J. Clin. Invest. | pmid:14149916 |
REID ME et al. | NUTRITIONAL STUDIES WITH THE GUINEA PIG. X. DETERMINATION OF THE LINOLEIC ACID REQUIREMENT. | 1964 | J. Nutr. | pmid:14151124 |
MOORE JH and WILLIAMS DL | THE EFFECT OF DIET ON THE LEVEL OF PLASMA CHOLESTEROL AND THE DEGREE OF ATHEROMATOUS DEGENERATION IN THE RABBIT. | 1964 | Br. J. Nutr. | pmid:14154252 |
SCOTT RF et al. | FATTY ACIDS OF SERUM AND ADIPOSE TISSUE IN SIX GROUPS EATING NATURAL DIETS CONTAINING 7 TO 40 PER CENT FAT. | 1964 | Am. J. Clin. Nutr. | pmid:14157830 |
FUHRMANN W | [STUDIES ON THE FATTY ACIDS OF PLASMA LIPIDS IN HEREDITARY CARBOHYDRATE-SENSITIVE HYPERLIPEMIA]. | 1964 | Dtsch. Med. Wochenschr. | pmid:14157955 |
CENTURY B and HORWITT MK | ROLE OF ARACHIDONIC ACID IN NUTRITIONAL ENCEPHALOMALACIA: INTERRELATIONSHIP OF ESSENTIAL AND NONESSENTIAL POLYUNSATURATED FATTY ACIDS. | 1964 | Arch. Biochem. Biophys. | pmid:14161009 |
BRESSLER R and FRIEDBERG SJ | SUBSTRATE SPECIFICITY OF THE FATTY ACID OXIDASE IN THE HEART. | 1964 | Arch. Biochem. Biophys. | pmid:14161011 |
ARFFMANN E | HEATED FATS AND ALLIED COMPOUNDS AS CARCINOGENS; STUDIED BY THE NEWT TEST. | 1964 | Acta Pathol Microbiol Scand | pmid:14162795 |
GOLD M and SPITZER JJ | METABOLISM OF FREE FATTY ACIDS BY MYOCARDIUM AND KIDNEY. | 1964 | Am. J. Physiol. | pmid:14111431 |
SPITZER JJ and GOLD M | FREE FATTY ACID METABOLISM BY SKELETAL MUSCLE. | 1964 | Am. J. Physiol. | pmid:14111432 |
GOODMAN DS et al. | THE FORMATION OF CHOLESTEROL ESTERS WITH RAT LIVER ENZYMES. | 1964 | J. Biol. Chem. | pmid:14189863 |
MORIN RJ and ALFIN-SLATER RB | FACTORS AFFECTING HEPATIC PHOSPHOLIPID SYNTHESIS. | 1964 | Metab. Clin. Exp. | pmid:14105462 |
WAKU K and NAKAZAWA Y | ON THE LIPIDS OF RABBIT SARCOPLASMIC RETICULUM. | 1964 | J. Biochem. | pmid:14202242 |
PIETROPAOLO C et al. | FATTY ACID COMPOSITION OF PATHOLOGICAL BODY FLUIDS. | 1964 | Clin. Chim. Acta | pmid:14203246 |
WALKER BL and KUMMEROW FA | DIETARY FAT AND THE STRUCTURE AND PROPERTIES OF RAT ERYTHROCYTES. III. RESPONSE OF ERYTHROCYTE FATTY ACIDS TO VARIOUS DIETARY FATS. | 1964 | J. Nutr. | pmid:14133362 |
HOLMAN RT et al. | ESTIMATION OF LINOLEATE INTAKE OF MEN FROM SERUM LIPID ANALYSIS. | 1964 | Am. J. Clin. Nutr. | pmid:14142377 |
ELLEFSON RD and MASON HL | EFFECTS OF DEFICIENCY AND EXCESS OF THYROID HORMONE ON THE DISTRIBUTION OF FATTY ACIDS IN LIPIDS OF THE RAT. | 1964 | Endocrinology | pmid:14206987 |
VAHOUNY GV et al. | MICELLAR-SOLUBILIZED SUBSTRATES AND CHOLESTEROL ESTERASE ACTIVITY IN VITRO. | 1964 | Arch. Biochem. Biophys. | pmid:14211570 |
MACDONALD I and BARRY PJ | CHANGES IN THE FATTY ACID PATTERN OF THE ADIPOSE TISSUE OF OBESE SUBJECTS WHILE ON A REDUCING REGIMEN. | 1964 | Am. J. Clin. Nutr. | pmid:14212750 |
KOEHLER WR et al. | A METHOD FOR SEPARATING SATURATED FATTY ACID ESTERS FROM UNSATURATED ESTERS FOR GAS CHROMATOGRAPHIC ANALYSIS. | 1964 | Anal. Biochem. | pmid:14213999 |
PINTER KG et al. | FAT ABSORPTION STUDIES IN VARIOUS FORMS OF STEATORRHEA. | 1964 | Am. J. Clin. Nutr. | pmid:14220479 |
KORN ED | BIOSYNTHESIS OF UNSATURATED FATTY ACIDS IN ACANTHAMOEBA SP. | 1964 | J. Biol. Chem. | pmid:14169137 |
WILLEBRANDS AF | MYOCARDIAL EXTRACTION OF INDIVIDUAL NON-ESTERIFIED FATTY ACIDS, ESTERIFIED FATTY ACIDS AND ACETOACETATE IN THE FASTING HUMAN. | 1964 | Clin. Chim. Acta | pmid:14230940 |
PORTMAN OW and SUGANO M | FACTORS INFLUENCING THE LEVEL AND FATTY ACID SPECIFICITY OF THE CHOLESTEROL ESTERIFICATION ACTIVITY IN HUMAN PLASMA. | 1964 | Arch. Biochem. Biophys. | pmid:14236639 |
JACKSON HD et al. | FORMATION OF KETONE BODIES FROM LONG-CHAIN FATTY ACIDS IN RUMEN EPITHELIUM AND LIVER FROM KETOTIC SHEEP. | 1964 | Arch. Biochem. Biophys. | pmid:14240563 |
MOORE JH and WILLIAMS D | THE RELATIONSHIP BETWEEN THE LINOLEIC ACID CONTENT OF THE DIET, THE FATTY ACID COMPOSITION OF THE PLASMA PHOSPHOLIPIDS AND THE DEGREE OF AORTIC ATHEROSIS IN EXPERIMENTAL RABBITS. | 1964 | Br. J. Nutr. | pmid:14241591 |
ZUCKERMAN AJ and MACDONAID L | THE ROLE OF DIETARY CARBOHYDRATES AND INFECTION ON LIVER LIPID AND COLLAGEN. | 1964 | Br J Exp Pathol | pmid:14245158 |
SIMON ER and WAYS P | INCUBATION HEMOLYSIS AND RED CELL METABOLISM IN ACANTHOCYTOSIS. | 1964 | J. Clin. Invest. | pmid:14192511 |
CALVERT CC et al. | EFFECT OF LINOLEIC ACID ON NUTRITIONAL MUSCULAR DYSTROPHY IN THE CHICK. | 1964 | J. Nutr. | pmid:14194429 |
WEIGENSBERG BI and MCMILLAN GC | SERUM AND AORTIC LIPIDS IN RABBITS FED CHOLESTEROL AND LINOLEIC ACID STEREOISOMERS. | 1964 | J. Nutr. | pmid:14194430 |
HAVEL RJ et al. | TURNOVER RATE AND OXIDATION OF DIFFERENT FREE FATTY ACIDS IN MAN DURING EXERCISE. | 1964 | J Appl Physiol | pmid:14195568 |
RAHM JJ and HOLMAN RT | EFFECT OF LINOLEIC ACID UPON THE METABOLISM OF LINOLENIC ACID. | 1964 | J. Nutr. | pmid:14210015 |
IMAI Y and ARAMAKI Y | LINOLEIC ACID COMPONENT IN THE HYPERLIPIDEMIA INDUCED BY TRITON. | 1964 | Jpn. J. Pharmacol. | pmid:14215540 |
POLAN CE et al. | BIOHYDROGENATION OF UNSATURATED FATTY ACIDS BY RUMEN BACTERIA. | 1964 | J. Bacteriol. | pmid:14219019 |
HITCHCOCK C and JAMES AT | OXIDATION OF UNSATURATED FATTY ACIDS BY LEAF TISSUE. | 1964 | J. Lipid Res. | pmid:14221105 |
HULANICKA D et al. | LIPID METABOLISM OF EUGLENA GRACILIS. | 1964 | J. Biol. Chem. | pmid:14216427 |
ISSELBACHER KJ et al. | CONGENITAL BETA-LIPOPROTEIN DEFICIENCY: AN HEREDITARY DISORDER INVOLVING A DEFECT IN THE ABSORPTION AND TRANSPORT OF LIPIDS. | 1964 | Medicine (Baltimore) | pmid:14168744 |
DESAI ID et al. | PEROXIDATIVE AND RADIATION DAMAGE TO ISOLATED LYSOSOMES. | 1964 | Biochim. Biophys. Acta | pmid:14171002 |
LYMAN RL et al. | LIVER LIPID ACCUMULATION IN ISOLEUCINE-DEFICIENT RATS. | 1964 | J. Nutr. | pmid:14151129 |
GUNNING BE et al. | EFFECTS OF DIFFERENT DIETARY FATS ON PLASMA-LIPID LEVELS. | 1964 | Lancet | pmid:14172332 |
PINTER KG et al. | QUANTITATIVE DETERMINATION OF SERUM TRIGLYCERIDES BY GLASS-FIBER PAPER CHROMATOGRAPHY. | 1964 | Anal. Biochem. | pmid:14186669 |
BJOERNTORP P et al. | ALBUMIN ANTAGONISM OF FATTY ACID EFFECTS ON OXIDATION AND PHOSPHORYLATION REACTIONS IN RAT LIVER MITOCHONDRIA. | 1964 | J. Biol. Chem. | pmid:14114863 |
ONO K and FREDRICKSON DS | THE METABOLISM 14C-LABELED CIS AND TRANS ISOMERS OF OCTADECENOIC AND OCTADECADIENOIC ACIDS. | 1964 | J. Biol. Chem. | pmid:14235525 |
BENJAMIN W and GELLHORN A | THE EFFECT OF DIABETES AND INSULIN ON THE BIOSYNTHESIS OF INDIVIDUAL FATTY ACIDS IN ADIPOSE TISSUE. | 1964 | J. Biol. Chem. | pmid:14114873 |
SWELL L et al. | ROLE OF THE LIVER IN THE METABOLISM OF EXOGENOUS CHOLESTEROL ESTERS. | 1964 | Arch. Biochem. Biophys. | pmid:14236640 |
FUTTERMAN S and ANDREWS JS | METABOLISM OF THE RETINA. IV. THE COMPOSITION OF VITAMIN A ESTER SYNTHESIZED BY THE RETINA. | 1964 | J. Biol. Chem. | pmid:14114876 |
WOODALL AN et al. | NUTRITION OF SALMONOID FISHES. 13. THE ALPHA-TOCOPHEROL REQUIREMENT OF CHINOOK SALMON. | 1964 | J. Nutr. | pmid:14236910 |
RAHM JJ and HOLMAN RT | STUDIES OF THE METABOLISM OF POLYUNSATURATED ACIDS BY SHORT-TERM EXPERIMENTS. | 1964 | J. Nutr. | pmid:14236913 |
ENGELMANN D et al. | [CONCERNING THE RESORPTION AND METABOLISM OF SOME 1-14C-LABELLED FREE FATTY ACIDS IN YOUNG RABBITS]. | 1964 | Clin. Chim. Acta | pmid:14122499 |
PARKER F et al. | THE ENZYMATIC NATURE OF PHOSPHOLIPID SYNTHESIS IN NORMAL RABBIT AND HUMAN AORTA. RESULTS OF IN VITRO STUDIES. | 1964 Mar-Apr | Diabetes | pmid:14127432 |
NESTEL PJ | METABOLISM OF LINOLEATE AND PALMITATE IN PATIENTS WITH HYPERTRIGLYCERIDEMIA AND HEART DISEASE. | 1965 | Metab. Clin. Exp. | pmid:14252339 |
CHRISTAKIS GJ et al. | EFFECT OF A SERUM CHOLESTEROL-LOWERING DIET ON COMPOSITION OF DEPOT FAT IN MAN. | 1965 | Am. J. Clin. Nutr. | pmid:14253897 |
ZUKEL MC | FAT-CONTROLLED DIETS. | 1965 | Am. J. Clin. Nutr. | pmid:14253901 |
MARION JE | EFFECT OF AGE AND DIETARY FAT ON THE LIPIDS OF CHICKEN MUSCLE. | 1965 | J. Nutr. | pmid:14257000 |
PRIVETT OS et al. | INFLUENCE OF DIETARY FAT ON TRIGLYCERIDE STRUCTURE IN THE RAT. | 1965 | J. Nutr. | pmid:14259460 |
YAMAMOTO A et al. | INFLUENCE OF DIETARY FATTY ACIDS ON PHOSPHOLIPID FATTY ACID COMPOSITION IN SUBCELLULAR PARTICLES OF RAT LIVER. | 1965 | J. Lipid Res. | pmid:14330770 |
CAMPBELL AM et al. | SERUM LIPIDS OF MEN FED DIETS DIFFERING IN PROTEIN QUALITY AND LINOLEIC ACID CONTENT. | 1965 | Am. J. Clin. Nutr. | pmid:14332349 |
KOKATNUR MG et al. | A RAPID METHOD FOR THE PREPARATION OF PEROXIDES FROM AUTOXIDIZED METHYL ESTERS OF FATTY ACIDS. | 1965 | Anal. Biochem. | pmid:14340025 |
SGOUTAS D et al. | RADIOHOMOGENEITY OF H3- AND C14-LABELED LINOLEIC ACID IN VIVO. | 1965 | J. Lipid Res. | pmid:14343270 |
HARRIS RV and JAMES AT | CONVERSION OF OLEIC ACID INTO LINOLEIC ACID BY A SUBCELLULAR SYSTEM OF CHLORELLA VULGARIS. | 1965 | Biochem. J. | pmid:14346083 |
ALLMANN DW and GIBSON DM | FATTY ACID SYNTHESIS DURING EARLY LINOLEIC ACID DEFICIENCY IN THE MOUSE. | 1965 | J. Lipid Res. | pmid:14280473 |
ALLMANN DW et al. | FATTY ACID SYNTHESIS DURING FAT-FREE REFEEDING OF STARVED RATS. | 1965 | J. Lipid Res. | pmid:14280474 |
SHAW R | THE OCCURRENCE OF GAMMA-LINOLENIC ACID IN FUNGI. | 1965 | Biochim. Biophys. Acta | pmid:14320219 |
WILLS ED | MECHANISMS OF LIPID PEROXIDE FORMATION IN TISSUES. ROLE OF METALS AND HAEMATIN PROTEINS IN THE CATALYSIS OF THE OXIDATION UNSATURATED FATTY ACIDS. | 1965 | Biochim. Biophys. Acta | pmid:14325327 |
MEGHAL SK and NATH MC | ACTION OF FATS AND LINOLEIC ACID ON INTESTINAL SYNTHESIS OF THIAMINE IN THIAMINE-DEFICIENT RATS. | 1965 | Br. J. Nutr. | pmid:14290858 |
DANIEL JC | STUDIES ON THE GROWTH OF 5-DAY-OLD RABBIT BLASTOCYSTS IN VITRO. | 1965 | J Embryol Exp Morphol | pmid:14296279 |
GLENN JL and DAM H | INFLUENCE OF DIETARY LIPIDS ON THE FATTY ACID COMPOSITION OF NEUTRAL LIPIDS AND PHOSPHATIDES IN CHICK LIVER AND BILE. | 1965 | J. Nutr. | pmid:14300993 |
KRAUSE RF | LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A. | 1965 | Am. J. Clin. Nutr. | pmid:14301352 |
JAMES AT et al. | THE BIOSYNTHESIS OF RICINOLEIC ACID. | 1965 | Biochem. J. | pmid:14340094 |
SCHWARTZ S et al. | LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. | 1965 | Am. J. Med. Sci. | pmid:14254823 |
SINGLETON WS | CHARACTERIZED OILS FOR USE IN INTRAVENOUS FAT EMULSIONS. | 1965 | Am. J. Clin. Nutr. | pmid:14262113 |
MORIN RJ | EFFECTS OF 4-DIMETHYLAMINOAZOBENZENE ON HEPATIC MICROSOMAL PHOSPHOLIPIDS. | 1965 | Cancer Res. | pmid:14264043 |
STEIN AA et al. | FATTY ACID ANALYSIS OF TWO EXPERIMENTAL TRANSMISSIBLE GLIAL TUMORS BY GAS-LIQUID CHROMATOGRAPHY. | 1965 | Cancer Res. | pmid:14264052 |
BAKER RW et al. | SERUM CHOLESTEROL LINOLEATE LEVELS IN MULTIPLE SCLEROSIS. | 1965 | J. Neurol. Neurosurg. Psychiatr. | pmid:14347622 |
ANSTALL HB and TRUJILLO JM | DETERMINATION OF FREE FATTY ACIDS IN PLASMA BY A COLORIMETRIC PROCEDURE: AN APPRAISAL OF THE METHOD AND COMPARISON WITH OTHER TECHNICS. | 1965 | Clin. Chem. | pmid:14319230 |
GLENDE EA and CORNATZER WE | FATTY ACID COMPOSITION OF RAT LIVER LIPIDS DURING CHOLINE DEFICIENCY. | 1965 | J. Nutr. | pmid:14302120 |
HOLMES FE | AIR-COOLED EXTRACTORS AND THEIR USE IN DETERMINATION OF CHOLESTEROL. | 1965 | Clin. Chem. | pmid:14243897 |
Kabara JJ et al. | Fatty acids and derivatives as antimicrobial agents. | 1972 | Antimicrob. Agents Chemother. | pmid:4670656 |
Kohn A et al. | Interaction of polyunsaturated fatty acids with animal cells and enveloped viruses. | 1980 | Antimicrob. Agents Chemother. | pmid:7235682 |
Volpe JJ and Obert KA | Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. | 1981 | Arch. Biochem. Biophys. | pmid:6118099 |
Lewis MG et al. | Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. | 1981 | Prostaglandins | pmid:6799988 |
Gavigan SJ and Knight BL | Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids. | 1981 | Biochim. Biophys. Acta | pmid:6271233 |
Cheah AM | Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. | 1981 | Biochim. Biophys. Acta | pmid:6118177 |
Liffmann SM and Lynch RD | Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. | 1981 | Biochim. Biophys. Acta | pmid:7295748 |
Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
Houtsmuller UM and van der Beek A | Effects of topical application of fatty acids. | 1981 | Prog. Lipid Res. | pmid:6804961 |
Spector AA et al. | Utilization of arachidonic and linoleic acids by cultured human endothelial cells. | 1981 | J. Clin. Invest. | pmid:6793627 |
Kinsella JE et al. | Metabolism of trans fatty acids with emphasis on the effects of trans, trans-octadecadienoate on lipid composition, essential fatty acid, and prostaglandins: an overview. | 1981 | Am. J. Clin. Nutr. | pmid:6794350 |
Andersen BR et al. | The effects of arachidonic and other fatty acids on canine neutrophil metabolism. | 1981 | Prostaglandins | pmid:6795686 |
McDaniel HG et al. | Glucose-insulin-potassium induced alterations in individual plasma free fatty acids in patients with acute myocardial infarction. | 1981 | Am. Heart J. | pmid:6787909 |
Naidoo J | Effect of pH on inhibition of plasmid-carrying cultures of Staphylococcus aureus by lipids. | 1981 | J. Gen. Microbiol. | pmid:7320698 |
Cunnane SC | Diodoquin and linoleic acid absorption in zinc deficiency. | 1981 | Am. J. Clin. Nutr. | pmid:6792900 |
Schieberle P et al. | A study of oxygen isotope scrambling in the enzymic and non-enzymic oxidation of linoleic acid. | 1981 | Biochim. Biophys. Acta | pmid:6798993 |
Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
Mercuri O and De Tomás ME | Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. | 1981 | Prog. Lipid Res. | pmid:6804968 |
Kuriki Y | Effects of unsaturated fatty acids on the morphogenesis of an unsaturated fatty acid auxotroph of Escherichia coli. | 1981 | J. Bacteriol. | pmid:7024246 |