Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Alopecia D000505 14 associated lipids
Liver Diseases D008107 31 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Seizures D012640 87 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hypertension, Renal D006977 9 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Aortic Diseases D001018 11 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice. 2013 Br. J. Nutr. pmid:22883314
Chukir T et al. Shared retronasal identifications of vapor-phase 18-carbon fatty acids. 2013 Chem. Senses pmid:23424022
Anton SD et al. Differential effects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health. 2013 J Integr Med pmid:23464640
Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
Moon C et al. Modeling sulfate removal by inhibited mesophilic mixed anaerobic communities using a statistical approach. 2013 Water Res. pmid:23466036
Sy C et al. Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: comparison with common carotenoids. 2013 Food Funct pmid:23411789
Salama el-S et al. Biomass, lipid content, and fatty acid composition of freshwater Chlamydomonas mexicana and Scenedesmus obliquus grown under salt stress. 2013 Bioprocess Biosyst Eng pmid:23411874
Bae WK et al. Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer. 2013 Biomaterials pmid:23174142
Girgih AT et al. Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. 2013 Plant Foods Hum Nutr pmid:23417711
Zuo R et al. Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets. 2013 Br. J. Nutr. pmid:23452520
Schneider MR et al. Differentially regulated microRNAs during human sebaceous lipogenesis. 2013 J. Dermatol. Sci. pmid:23452545
Lind PM et al. An environmental wide association study (EWAS) approach to the metabolic syndrome. 2013 Environ Int pmid:23454278
Shen W et al. Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. 2013 J. Lipid Res. pmid:23401602
Lai MC et al. The natural PPAR agonist linoleic acid stimulated insulin release in the rat pancreas. 2013 J. Vet. Med. Sci. pmid:23832628
Song Y et al. Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members. 2013 Lipids Health Dis pmid:23879935
Wei J et al. Linoleic acid attenuates endothelium-derived relaxing factor production by suppressing cAMP-hydrolyzing phosphodiesterase activity. 2013 Circ. J. pmid:23883876
Zhao X et al. Analysis of fatty acids and phytosterols in ethanol extracts of Nelumbo nucifera seeds and rhizomes by GC-MS. 2013 J. Agric. Food Chem. pmid:23742045
Renner L et al. Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells. 2013 Nutrients pmid:23857174
Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
Giua L et al. Oxidative modifications of conjugated and unconjugated linoleic acid during heating. 2013 Food Chem pmid:23692753
Liu Q et al. Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). 2013 Theor. Appl. Genet. pmid:23695179
Khalil WA et al. Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. 2013 Theriogenology pmid:23683689
Le Maux S et al. β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. 2013 J. Dairy Sci. pmid:23684041
Raatz SK et al. Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. 2013 J Acad Nutr Diet pmid:23351633
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
Ramsden CE et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. 2013 BMJ pmid:23386268
Calder PC Old study sheds new light on the fatty acids and cardiovascular health debate. 2013 BMJ pmid:23386269
Benjamin S et al. Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model. 2013 J Zhejiang Univ Sci B pmid:23365010
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Chiou TY et al. Characteristics and antioxidative ability of defatted rice bran extracts obtained using several extractants under subcritical conditions. 2013 J Oleo Sci pmid:23357811
Fijlstra M et al. Reduced absorption of long-chain fatty acids during methotrexate-induced gastrointestinal mucositis in the rat. 2013 Clin Nutr pmid:23102689
Zlatanov MD et al. Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils. 2013 J. Sci. Food Agric. pmid:23174908
Toral PG et al. Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. 2013 J. Dairy Sci. pmid:23164228
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Ali Q et al. Ameliorating effects of exogenously applied proline on seed composition, seed oil quality and oil antioxidant activity of maize (Zea mays L.) under drought stress. 2013 Int J Mol Sci pmid:23344043
Jemia MB et al. Studies on the antioxidant activity of the essential oil and extract of Tunisian Tetraclinis articulata (Vahl) Mast. (Cupressaceae). 2013 Nat. Prod. Res. pmid:23082942
Ogata F et al. Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). 2013 J Oleo Sci pmid:23391535
Ghisolfi J et al. Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. 2013 Public Health Nutr pmid:23098567
Poon JF et al. In search of catalytic antioxidants--(alkyltelluro)phenols, (alkyltelluro)resorcinols, and bis(alkyltelluro)phenols. 2013 J. Org. Chem. pmid:23701313
Chodok P et al. Identification and functional characterization of two Δ12-fatty acid desaturases associated with essential linoleic acid biosynthesis in Physcomitrella patens. 2013 J. Ind. Microbiol. Biotechnol. pmid:23702573
Benjakul S et al. Antioxidant activity and inhibitory effects of lead (Leucaena leucocephala) seed extracts against lipid oxidation in model systems. 2013 Food Sci Technol Int pmid:23729420
Katan MB [Linoleic acid and heart infarct]. 2013 Ned Tijdschr Geneeskd pmid:23714298
Ndhlala AR et al. Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. 2013 Molecules pmid:23377133
Han L et al. Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. 2013 Food Chem. Toxicol. pmid:23959106
Aboshi T et al. Biosynthesis of linoleic acid in Tyrophagus mites (Acarina: Acaridae). 2013 Insect Biochem. Mol. Biol. pmid:23973745
Özcan T Accumulation patterns of some seed oil components from wild sources of Turkey. 2013 Nat. Prod. Res. pmid:22233192
Li KC et al. [A preliminary study of the inhibitive efficacy of iodized linoleic acid and its fluorodeoxyuridine ester in hepatocellular cancer]. 2013 Zhonghua Gan Zang Bing Za Zhi pmid:24025140
Stelzleni AM et al. Effects of feeding extruded full-fat cottonseed pellets in place of tallow as a fat source for finishing heifers on feedlot performance, carcass characteristics, sensory traits, display color, and fatty acid profiles. 2013 J. Anim. Sci. pmid:23893987
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Caligiuri SP et al. Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. 2013 J. Nutr. pmid:23902961
Kenny JG et al. Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. 2013 PLoS ONE pmid:23861785
Xie J et al. A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery. 2013 Biomed Res Int pmid:23862153
Smink W et al. Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. 2013 J Anim Physiol Anim Nutr (Berl) pmid:22463497
Benbrook CM et al. Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. 2013 PLoS ONE pmid:24349282
Green DP et al. Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. 2013 Pain pmid:23891895
Ruparel S et al. Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. 2013 Pain pmid:23867730
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Sisignano M et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. 2013 PLoS ONE pmid:24349046
Vukašinović EL et al. Diapause induces changes in the composition and biophysical properties of lipids in larvae of the European corn borer, Ostrinia nubilalis (Lepidoptera: Crambidae). 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23701990
Layek B and Singh J Cell penetrating peptide conjugated polymeric micelles as a high performance versatile nonviral gene carrier. 2013 Biomacromolecules pmid:24083483
Luo X et al. Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli. 2013 Mol. Biol. Rep. pmid:24062071
Yamagishi K et al. Plasma fatty acid composition and incident ischemic stroke in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. 2013 Cerebrovasc. Dis. pmid:23920478
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Alinezhad H et al. Biochemical activities of acetone extracts of Hyssopus angustifolius. 2012 Jul-Aug Acta Pol Pharm pmid:22876603
Moghaddam AH et al. Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. 2012 Jul-Aug Acta Pol Pharm pmid:22876611
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Chivandi E et al. Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. 2012 Jan-Feb In Vivo pmid:22210722
Matsubara T et al. TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. 2012 J. Lipid Res. pmid:23034213
Ruparel S et al. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. 2012 Pain pmid:22633978
Naqvi AZ et al. Dietary fatty acids and peripheral artery disease in adults. 2012 Atherosclerosis pmid:22552117
Perdriau S et al. Selective conversion of polyenes to monoenes by RuCl(3) -catalyzed transfer hydrogenation: the case of cashew nutshell liquid. 2012 ChemSusChem pmid:23060315
O'Donnell-Megaro AM et al. Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. 2012 J. Dairy Sci. pmid:23063161
Coimbra MC and Jorge N Fatty acids and bioactive compounds of the pulps and kernels of Brazilian palm species, guariroba (Syagrus oleraces), jerivá (Syagrus romanzoffiana) and macaúba (Acrocomia aculeata). 2012 J. Sci. Food Agric. pmid:21922463
Ruparel S et al. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 2012 Mol Pain pmid:23006841
Kanter JE et al. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. 2012 Biochim. Biophys. Acta pmid:22020260
Poompachee K and Chudapongse N Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. 2012 Med Princ Pract pmid:22024634
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Stachowska E et al. Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. 2012 Int J Food Sci Nutr pmid:21721848
Levitan EB et al. α-Linolenic acid, linoleic acid and heart failure in women. 2012 Br. J. Nutr. pmid:22172525
Taârit MB et al. Physiological changes, phenolic content and antioxidant activity of Salvia officinalis L. grown under saline conditions. 2012 J. Sci. Food Agric. pmid:22173568
Byun HJ et al. Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. 2012 J. Dermatol. Sci. pmid:22209282
Cheguru P et al. Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. 2012 Pflugers Arch. pmid:22218833
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
Beevi SS et al. Polyphenolics profile and antioxidant properties of Raphanus sativus L. 2012 Nat. Prod. Res. pmid:21714734
Zengin G et al. Composition of essential oil and antioxidant capacity of Centaurea drabifolia Sm. subsp. detonsa (Bornm.) Wagenitz, endemic to Turkey. 2012 Nat. Prod. Res. pmid:21714737
Kuipers RS et al. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425685
Li D et al. Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings. 2012 Int J Nanomedicine pmid:23269869
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Zened A et al. In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. 2012 Animal pmid:22436225
Marei WF et al. Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. 2012 Reprod. Fertil. Dev. pmid:22697118
Wu J et al. Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. 2012 Acta Biochim. Biophys. Sin. (Shanghai) pmid:22687573
Reynolds CM et al. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. 2012 Mol Nutr Food Res pmid:22700321
Ladeira MM et al. Lipids in the diet and the fatty acid profile in beef: a review and recent patents on the topic. 2012 Recent Pat Food Nutr Agric pmid:22702746
Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Yu T et al. Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. 2012 Pflugers Arch. pmid:22644615
Xie J et al. Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. 2012 Nat. Prod. Res. pmid:21707231