| MeSH term | MeSH ID | Detail |
|---|---|---|
| Constipation | D003248 | 8 associated lipids |
| Community-Acquired Infections | D017714 | 8 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Hyperlipidemia, Familial Combined | D006950 | 9 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Coronary Restenosis | D023903 | 10 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Hyperpigmentation | D017495 | 11 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Abushufa R et al. | Essential fatty acid status in patients on long-term home parenteral nutrition. | 1995 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:8523627 |
| Siguel E | Essential fatty acid status in patients. | 1997 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:9252955 |
| Cotter R et al. | Fatty acid profiles in response to soybean oil lipid emulsion infusions in essential fatty acid-deficient miniature swine. | 1988 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:3129587 |
| Ghisolfi J et al. | Metabolic utilization of linoleic acid from fat emulsion in infants during total parenteral nutrition. | 1988 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:3138449 |
| Lester LA et al. | Supplemental parenteral nutrition in cystic fibrosis. | 1986 May-Jun | JPEN J Parenter Enteral Nutr | pmid:3086588 |
| Lokesh B et al. | Effect of different dietary triglycerides on liver fatty acids and prostaglandin synthesis by mouse peritoneal cells. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1640628 |
| Clouva-Molyvdas P et al. | Short-term dietary lipid manipulation does not affect survival in two models of murine sepsis. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1640632 |
| Sakurai T et al. | Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas. | 2002 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:11871742 |
| Burton AF and Anderson FH | Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats. | 1985 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:3839859 |
| Diboune M et al. | Composition of phospholipid fatty acids in red blood cell membranes of patients in intensive care units: effects of different intakes of soybean oil, medium-chain triglycerides, and black-currant seed oil. | 1992 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:1556808 |
| Cabré E et al. | Plasma polyunsaturated fatty acids in liver cirrhosis with or without chronic hepatic encephalopathy: a preliminary study. | 1992 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:1386392 |
| Kim JY and Chung BH | Effects of combination dietary conjugated linoleic acid with vitamin A (retinol) and selenium on the response of the immunoglobulin production in mice. | 2003 | J. Vet. Sci. | pmid:12819373 |
| Craven J et al. | Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs? | 2002 | J. Vet. Pharmacol. Ther. | pmid:12423225 |
| Sato I et al. | Antioxidative and antigenotoxic effects of Japanese horse chestnut (Aesculus turbinata) seeds. | 2005 | J. Vet. Med. Sci. | pmid:16082125 |
| Masuda A et al. | Study of lipid in the ear canal in canine otitis externa with Malassezia pachydermatis. | 2000 | J. Vet. Med. Sci. | pmid:11129861 |
| Lai MC et al. | The natural PPAR agonist linoleic acid stimulated insulin release in the rat pancreas. | 2013 | J. Vet. Med. Sci. | pmid:23832628 |
| Sato I et al. | Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds. | 2007 | J. Vet. Med. Sci. | pmid:17675801 |
| Fukuda S et al. | Production of conjugated linoleic acid by intestinal bacteria in dogs and cats. | 2002 | J. Vet. Med. Sci. | pmid:12499682 |
| Tominaga K et al. | Effect of linoleic acid-albumin on post-thaw survival of in vitro-produced bovine embryos at the 16-cell stage. | 2000 | J. Vet. Med. Sci. | pmid:10823739 |
| Hochi S et al. | Nuclear transfer in cattle : effect of linoleic acid-albumin on freezing sensitivity of enucleated oocytes. | 2000 | J. Vet. Med. Sci. | pmid:11073086 |
| Hall JA et al. | Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. | 1997 Jul-Aug | J. Vet. Intern. Med. | pmid:9298479 |
| Hansen RA et al. | Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. | 2002 Jul-Aug | J. Vet. Intern. Med. | pmid:12141309 |
| Attar-Bashi NM et al. | Alpha-linolenic acid and the risk of prostate cancer. What is the evidence? | 2004 | J. Urol. | pmid:15017185 |
| Higashi-Okai K et al. | Antioxidant and prooxidant activities of B group vitamins in lipid peroxidation. | 2006 | J. UOEH | pmid:17209512 |
| Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activities of traditional Japanese cereal grains. | 2008 | J. UOEH | pmid:19086696 |
| Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activity of Chenpi--compensatory and cooperative actions of ascorbic acid and citric acid. | 2009 | J. UOEH | pmid:20000005 |
| Pyles LA et al. | Plasma antioxidant depletion after cardiopulmonary bypass in operations for congenital heart disease. | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609540 |
| Opara EC et al. | Enhancement of endocrine pancreatic secretions by essential fatty acids. | 1990 | J. Surg. Res. | pmid:2187112 |
| Garfinkel M et al. | Insulinotropic potency of lauric acid: a metabolic rationale for medium chain fatty acids (MCF) in TPN formulation. | 1992 | J. Surg. Res. | pmid:1593871 |
| Thibodeau PA et al. | In vitro pro- and antioxidant properties of estrogens. | 2002 | J. Steroid Biochem. Mol. Biol. | pmid:12163134 |
| Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
| Sabir A et al. | The fatty acid and tocopherol constituents of the seed oil extracted from 21 grape varieties (Vitis spp.). | 2012 | J. Sci. Food Agric. | pmid:22271548 |
| Corrêa RC et al. | Antioxidant and rheological properties of guava jam with added concentrated grape juice. | 2014 | J. Sci. Food Agric. | pmid:23696312 |
| Zlatanov MD et al. | Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils. | 2013 | J. Sci. Food Agric. | pmid:23174908 |
| Gámez-Meza N et al. | Chemical characterisation of kernels, kernel meals and oils from Jatropha cordata and Jatropha cardiophylla seeds. | 2013 | J. Sci. Food Agric. | pmid:23180465 |
| Baâtour O et al. | Salt effects on Origanum majorana fatty acid and essential oil composition. | 2011 | J. Sci. Food Agric. | pmid:21800320 |
| Coimbra MC and Jorge N | Fatty acids and bioactive compounds of the pulps and kernels of Brazilian palm species, guariroba (Syagrus oleraces), jerivá (Syagrus romanzoffiana) and macaúba (Acrocomia aculeata). | 2012 | J. Sci. Food Agric. | pmid:21922463 |
| Khadake R et al. | Functional and bioinformatic characterisation of sequence variants of Fad3 gene from flax. | 2011 | J. Sci. Food Agric. | pmid:21769878 |
| Bakır T et al. | Polar paradox revisited: analogous pairs of hydrophilic and lipophilic antioxidants in linoleic acid emulsion containing Cu(II). | 2013 | J. Sci. Food Agric. | pmid:23520052 |
| Guo HH et al. | XsFAD2 gene encodes the enzyme responsible for the high linoleic acid content in oil accumulated in Xanthoceras sorbifolia seeds. | 2014 | J. Sci. Food Agric. | pmid:23775588 |
| Taârit MB et al. | Physiological changes, phenolic content and antioxidant activity of Salvia officinalis L. grown under saline conditions. | 2012 | J. Sci. Food Agric. | pmid:22173568 |
| Pestana JM et al. | Effect of slaughter season and muscle type on the fatty acid composition, including conjugated linoleic acid isomers, and nutritional value of intramuscular fat in organic beef. | 2012 | J. Sci. Food Agric. | pmid:22473659 |
| Ngakegni-Limbili AC et al. | Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. | 2013 | J. Sci. Food Agric. | pmid:22692978 |
| Khan R et al. | Variation in oil content and fatty acid composition of the seed oil of Acacia species collected from the northwest zone of India. | 2012 | J. Sci. Food Agric. | pmid:22351513 |
| Surai PF et al. | Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken. | 2000 | J. Reprod. Fertil. | pmid:11058441 |
| Homa ST and Brown CA | Changes in linoleic acid during follicular development and inhibition of spontaneous breakdown of germinal vesicles in cumulus-free bovine oocytes. | 1992 | J. Reprod. Fertil. | pmid:1552477 |
| McEvoy TG et al. | Fatty acid composition of lipids in immature cattle, pig and sheep oocytes with intact zona pellucida. | 2000 | J. Reprod. Fertil. | pmid:10793638 |
| Nørskov NP et al. | Multicompartmental nontargeted LC-MS metabolomics: explorative study on the metabolic responses of rye fiber versus refined wheat fiber intake in plasma and urine of hypercholesterolemic pigs. | 2013 | J. Proteome Res. | pmid:23596967 |
| Hu ZP et al. | Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model. | 2012 | J. Proteome Res. | pmid:23078235 |
| Liu F et al. | Simultaneous silencing of GhFAD2-1 and GhFATB enhances the quality of cottonseed oil with high oleic acid. | 2017 | J. Plant Physiol. | pmid:28644971 |
| Liavonchanka A and Feussner I | Lipoxygenases: occurrence, functions and catalysis. | 2006 | J. Plant Physiol. | pmid:16386332 |
| Hall TD et al. | Changes during leaf expansion of ΦPSII temperature optima in Gossypium hirsutum are associated with the degree of fatty acid lipid saturation. | 2014 | J. Plant Physiol. | pmid:24594393 |
| Reiter RJ | Mechanisms of cancer inhibition by melatonin. | 2004 | J. Pineal Res. | pmid:15357667 |
| Mekhloufi J et al. | Antioxidant activity of melatonin and a pinoline derivative on linoleate model system. | 2005 | J. Pineal Res. | pmid:15978054 |
| Dauchy RT et al. | Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. | 2009 | J. Pineal Res. | pmid:19486272 |
| Gulcin I et al. | On the in vitro antioxidative properties of melatonin. | 2002 | J. Pineal Res. | pmid:12220332 |
| Zapolska-Downar D et al. | Trans fatty acids induce apoptosis in human endothelial cells. | 2005 | J. Physiol. Pharmacol. | pmid:16391418 |
| MORRIS B and SIMPSON-MORGAN MW | THE OXIDATION OF CONTINUOUSLY INFUSED CHYLOMICRON FATTY ACIDS BY UNANESTHETIZED RATS. | 1963 | J. Physiol. (Lond.) | pmid:14103556 |
| Matta JA et al. | TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. | 2007 | J. Physiol. (Lond.) | pmid:17038422 |
| Boscá F et al. | Involvement of type I and type II mechanisms in the linoleic acid peroxidation photosensitized by tiaprofenic acid. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:11195846 |
| Boscá F et al. | Evaluation of ketoprofen (R,S and R/S) phototoxicity by a battery of in vitro assays. | 1995 | J. Photochem. Photobiol. B, Biol. | pmid:8583281 |
| Valero M and Carrillo C | Effect of binary and ternary polyethyleneglycol and/or beta-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15157911 |
| Kubin A et al. | Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin. | 1996 | J. Photochem. Photobiol. B, Biol. | pmid:9002246 |
| Valero M and Esteban B | Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-beta-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15488720 |
| Bylund J et al. | Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435160 |
| Uotila P et al. | Relaxing effects of 15-lipoxygenase products of arachidonic acid on rat aorta. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3116200 |
| Obukowicz MG et al. | Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9765335 |
| Gerzer R et al. | Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6134818 |
| Harrell MD and Stimers JR | Differential effects of linoleic Acid metabolites on cardiac sodium current. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235270 |
| Tremblay-Mercier J et al. | Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20404010 |
| Hoelgaard A and Møllgaard B | Permeation of linoleic acid through skin in vitro. | 1982 | J. Pharm. Pharmacol. | pmid:6127396 |
| Ogata K et al. | Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. | 2008 | J. Pharm. Pharmacol. | pmid:18088500 |
| Kim T et al. | Pharmacokinetics of formulated tenoxicam transdermal delivery systems. | 2008 | J. Pharm. Pharmacol. | pmid:18088513 |
| Trommer H et al. | Further investigations on the role of ascorbic acid in stratum corneum lipid models after UV exposure. | 2005 | J. Pharm. Pharmacol. | pmid:16102251 |
| Lane ME et al. | Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. | 2005 | J. Pharm. Pharmacol. | pmid:15720779 |
| Chan BC et al. | Combating against methicillin-resistant Staphylococcus aureus - two fatty acids from Purslane (Portulaca oleracea L.) exhibit synergistic effects with erythromycin. | 2015 | J. Pharm. Pharmacol. | pmid:25212982 |
| Yamamoto A et al. | Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats. | 1994 | J. Pharm. Pharmacol. | pmid:7515417 |
| Hernández-Caselles T et al. | Stability of liposomes on long term storage. | 1990 | J. Pharm. Pharmacol. | pmid:1979618 |
| Kaufman MJ | Comparison of the free radical-scavenging ability of captopril and ascorbic acid in an in-vitro model of lipid oxidation. Implications for reperfusion injury and ACE inhibitor therapy. | 1994 | J. Pharm. Pharmacol. | pmid:8027931 |
| Yamashiro Y et al. | Effects of ursodeoxycholic acid treatment on essential fatty acid deficiency in patients with biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:8201513 |
| Andrassy RJ et al. | Linoleic acid enhances mitogen response and survival of septic weanling rats. | 1994 | J. Pediatr. Surg. | pmid:8201499 |
| Shimizu T et al. | Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:2324889 |
| Agostoni C et al. | Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:17204967 |
| Hsieh JC et al. | High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:25633498 |
| Fidler N et al. | Effects of human milk pasteurization and sterilization on available fat content and fatty acid composition. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9740204 |
| Walkowiak J et al. | Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:18030219 |
| Koletzko B et al. | Comparison of fatty acid composition of plasma lipid fractions in well-nourished Nigerian and German infants and toddlers. | 1986 Jul-Aug | J. Pediatr. Gastroenterol. Nutr. | pmid:3090220 |
| Hernell O et al. | Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids? | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8315552 |
| Leaf AA et al. | Factors affecting long-chain polyunsaturated fatty acid composition of plasma choline phosphoglycerides in preterm infants. | 1992 | J. Pediatr. Gastroenterol. Nutr. | pmid:1535657 |
| Deshpande GC et al. | Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial. | 2009 | J. Pediatr. Gastroenterol. Nutr. | pmid:19644398 |
| Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
| Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
| Cooke RJ et al. | Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 1. Effect on essential fatty acid status. | 1985 | J. Pediatr. Gastroenterol. Nutr. | pmid:3930688 |
| Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
| Hoffman DR et al. | Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540798 |
| Byrne WJ | Intralipid or Liposyn--comparable products? | 1982 | J. Pediatr. Gastroenterol. Nutr. | pmid:6310073 |
| Clark RM | Lack of correlation between changes in the concentrations of linoleate and arachidonate in human milk relative to total milk lipid. | 1988 Nov-Dec | J. Pediatr. Gastroenterol. Nutr. | pmid:3143822 |
| Lapillonne A et al. | Effects of liver transplantation on long-chain polyunsaturated fatty acid status in infants with biliary atresia. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10817283 |
| Decsi T et al. | Effect of type of early infant feeding on fatty acid composition of plasma lipid classes in full-term infants during the second 6 months of life. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10817286 |
| Ratnayake WM et al. | Essential fatty acids and their trans geometrical isomers in powdered and liquid infant formulas sold in Canada. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9327370 |