| MeSH term | MeSH ID | Detail |
|---|---|---|
| Constipation | D003248 | 8 associated lipids |
| Community-Acquired Infections | D017714 | 8 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Hyperlipidemia, Familial Combined | D006950 | 9 associated lipids |
| Coronary Restenosis | D023903 | 10 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Hyperpigmentation | D017495 | 11 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kageyama K et al. | Synergistic inhibition of DNA synthesis in Ehrlich ascites tumour cells by a combination of unsaturated fatty acids and hyperthermia. | 1989 | J Appl Toxicol | pmid:2926093 |
| Booker ML et al. | Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog. | 1989 | Gastroenterology | pmid:2507386 |
| Garcia Zevallos M and Farkas T | Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. | 1989 | Arch. Biochem. Biophys. | pmid:2786374 |
| Bates D | Lipids and multiple sclerosis. | 1989 | Biochem. Soc. Trans. | pmid:2546837 |
| Glatz JF et al. | Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. | 1989 | Am. J. Clin. Nutr. | pmid:2916448 |
| Bernbäck S et al. | Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. | 1989 | Biochim. Biophys. Acta | pmid:2917153 |
| Hubbard NE and Erickson KL | Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases. | 1989 | Cancer Lett. | pmid:2920371 |
| Balakrishnan A et al. | Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas. | 1989 | Cancer Res. | pmid:2643465 |
| Bourre JM et al. | The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. | 1989 | J. Nutr. | pmid:2576038 |
| Fairbank J et al. | Octadeca-9,11-dienoic acid in cervical intraepithelial neoplasia: a colposcopic study. | 1989 | Clin. Chim. Acta | pmid:2612010 |
| Park JH et al. | Effects of dietary linoleic acid on mucosal adaptation after small bowel resection. | 1989 | Digestion | pmid:2612750 |
| Meikle AW et al. | Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. | 1989 | Am. J. Physiol. | pmid:2558577 |
| Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
| Madison KC et al. | Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiation. | 1989 | J. Invest. Dermatol. | pmid:2473131 |
| Kurganov BI et al. | Kinetics of soybean lipoxygenase reaction in hydrated reversed micelles. | 1989 | Biochimie | pmid:2474334 |
| Grossi IM et al. | Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. | 1989 | Cancer Res. | pmid:2492204 |
| Gardner HW | Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. | 1989 | Biochim. Biophys. Acta | pmid:2492826 |
| Anderson GJ and Connor WE | On the demonstration of omega-3 essential-fatty-acid deficiency in humans. | 1989 | Am. J. Clin. Nutr. | pmid:2494878 |
| Byczkowski JZ and Kulkarni AP | Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2494999 |
| Kaduce TL et al. | Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells. | 1989 | J. Biol. Chem. | pmid:2496121 |
| Hamazaki S et al. | Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. | 1989 | Arch. Biochem. Biophys. | pmid:2500058 |
| Imaizumi K et al. | Effect of phosphatidylethanolamine and its constituent base on the metabolism of linoleic acid in rat liver. | 1989 | Biochim. Biophys. Acta | pmid:2508745 |
| Hansen O | Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. | 1989 | Biochim. Biophys. Acta | pmid:2554979 |
| Blond JP et al. | Effect of fenofibrate treatment on linoleic acid desaturation in liver of obese Zucker rats. | 1989 | Biochem. Pharmacol. | pmid:2764996 |
| Hrboticky N et al. | Effect of linoleic acid-rich infant formula feeding on brain synaptosomal lipid accretion and enzyme thermotropic behavior in the piglet. | 1989 | J. Lipid Res. | pmid:2769072 |
| Blanken R et al. | Effect of mineral oil and linoleic-acid-containing emulsions on the skin vapour loss of sodium-lauryl-sulphate-induced irritant skin reactions. | 1989 | Contact Derm. | pmid:2706971 |
| Zevenbergen JL and Houtsmuller UM | Effect of dietary fats on linoleic acid metabolism. A radiolabel study in rats. | 1989 | Biochim. Biophys. Acta | pmid:2713382 |
| Rose DP and Connolly JM | Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803300 |
| Mahfouz MM et al. | Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. | 1989 | Biochim. Biophys. Acta | pmid:2804072 |
| Furr HC et al. | The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. | 1989 | J. Nutr. | pmid:2703916 |
| Klein A et al. | The effect of fatty acids on the vulnerability of lymphocytes to cortisol. | 1989 | Metab. Clin. Exp. | pmid:2537454 |
| Christon R et al. | Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. | 1989 | Biochim. Biophys. Acta | pmid:2538158 |
| Shires SE et al. | Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. | 1989 | Biochim. Biophys. Acta | pmid:2493807 |
| Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
| Diehl AK et al. | Dietary intake and the prevalence of gallbladder disease in Mexican Americans. | 1989 | Gastroenterology | pmid:2583417 |
| Szamel M et al. | Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. | 1989 | J. Immunol. | pmid:2530278 |
| Brodersen R et al. | Multiple fatty acid binding to albumin in human blood plasma. | 1990 | Eur. J. Biochem. | pmid:2338079 |
| Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
| Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
| Teter BB et al. | Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. | 1990 | J. Nutr. | pmid:2380791 |
| DeLange RJ and Glazer AN | Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. | 1990 | Arch. Biochem. Biophys. | pmid:2297222 |
| Ha YL et al. | Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. | 1990 | Cancer Res. | pmid:2297758 |
| Kawahara J et al. | Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. | 1990 | Hypertension | pmid:2298478 |
| Borgeson CE et al. | Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. | 1990 | Biochim. Biophys. Acta | pmid:2248971 |
| Pal S and Davis PJ | N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2260969 |
| Shimizu T et al. | Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:2324889 |
| Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
| Hennig B et al. | Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. | 1990 | J. Nutr. | pmid:2329387 |
| Roe CR et al. | 2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation. | 1990 | J. Clin. Invest. | pmid:2332510 |
| Miyashita K et al. | Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. | 1990 | Biochim. Biophys. Acta | pmid:2386795 |
| Hamberg M and Hamberg G | Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). | 1990 | Arch. Biochem. Biophys. | pmid:2275553 |
| Ohtani H et al. | Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. | 1990 | J. Lipid Res. | pmid:2280182 |
| Lefkowith J et al. | Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. | 1990 | J. Exp. Med. | pmid:2307932 |
| Buckman DK et al. | Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. | 1990 | J. Nutr. | pmid:2313378 |
| Jakobsson A et al. | Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. | 1990 | Biochim. Biophys. Acta | pmid:2223867 |
| Buset M et al. | Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. | 1990 | Cancer Lett. | pmid:2322935 |
| Katzenellenbogen BS and Norman MJ | Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. | 1990 | Endocrinology | pmid:2404751 |
| Jensen MD et al. | Measurement of non-steady-state free fatty acid turnover. | 1990 | Am. J. Physiol. | pmid:2405695 |
| Medini L et al. | Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. | 1990 | Biochem. Pharmacol. | pmid:2105092 |
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| Lernhardt W | Fatty acid requirement of B lymphocytes activated in vitro. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302243 |
| Galaris D et al. | Ferrylmyoglobin-catalyzed linoleic acid peroxidation. | 1990 | Arch. Biochem. Biophys. | pmid:2383021 |
| Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
| Conquer J and Mahadevappa VG | Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2106881 |
| Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
| Lipids and multiple sclerosis. | 1990 | Lancet | pmid:1973215 | |
| Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
| Lester DS | In vitro linoleic acid activation of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2207179 |
| Buko VU | Beef fat prevents alcoholic liver disease in the rat. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2221295 |
| Opara EC et al. | Enhancement of endocrine pancreatic secretions by essential fatty acids. | 1990 | J. Surg. Res. | pmid:2187112 |
| Oliver MF | Linoleic acid, antioxidants and coronary heart disease. | 1990 | Biochem. Soc. Trans. | pmid:2088801 |
| Singer P et al. | A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. | 1990 | Atherosclerosis | pmid:2146966 |
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| Ando H et al. | Protein kinase C and linoleic acid-induced inhibition of melanogenesis. | 1990 | Pigment Cell Res. | pmid:2077533 |
| Kulkarni AP et al. | Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2105721 |
| Umeda F et al. | Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. | 1990 | Diabetes Res. Clin. Pract. | pmid:2106424 |
| Lasekan JB et al. | Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. | 1990 | Nutr Cancer | pmid:2106675 |
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| Moore SA et al. | Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. | 1990 | J. Neurochem. | pmid:2115069 |
| Nikolaev V et al. | Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2116790 |
| Mensink RP et al. | Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. | 1990 | Eur. J. Clin. Invest. | pmid:2121507 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
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| Stocker R et al. | Antioxidant activities of bile pigments: biliverdin and bilirubin. | 1990 | Meth. Enzymol. | pmid:2233302 |
| Glasgow WC and Eling TE | Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. | 1990 | Mol. Pharmacol. | pmid:2233691 |
| Abraham RD et al. | Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. | 1990 | Atherosclerosis | pmid:2112389 |
| Vaughan PF and Ball SG | The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. | 1990 | Biochem. Pharmacol. | pmid:1968340 |
| Field CJ et al. | Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. | 1990 | J. Biol. Chem. | pmid:2113530 |
| Kim D and Duff RA | Regulation of K+ channels in cardiac myocytes by free fatty acids. | 1990 | Circ. Res. | pmid:2119911 |
| Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |