| MeSH term | MeSH ID | Detail |
|---|---|---|
| Constipation | D003248 | 8 associated lipids |
| Community-Acquired Infections | D017714 | 8 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Hyperlipidemia, Familial Combined | D006950 | 9 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Coronary Restenosis | D023903 | 10 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Hyperpigmentation | D017495 | 11 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pilitsis JG et al. | Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observation. | 2002 | J. Neurosurg. | pmid:12186453 |
| Amtul Z et al. | Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids. | 2011 | J. Neurosci. Res. | pmid:21748777 |
| Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
| Parnas M et al. | Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. | 2009 | J. Neurosci. | pmid:19244513 |
| Field EJ and Joyce G | Duchenne muscular dystrophy: do both parents contribute genetically to the disease? | 1987 | J. Neurol. Sci. | pmid:3126270 |
| Cherayil GD | Sialic acid and fatty acid concentrations in lymphocytes, red blood cells and plasma from patients with multiple sclerosis. | 1984 | J. Neurol. Sci. | pmid:6699649 |
| Julu PO and Mutamba A | Comparison of short-term effects of insulin and essential fatty acids on the slowed nerve conduction of streptozotocin diabetes in rats. | 1991 | J. Neurol. Sci. | pmid:1663993 |
| BAKER RW et al. | SERUM CHOLESTEROL LINOLEATE LEVELS IN MULTIPLE SCLEROSIS. | 1965 | J. Neurol. Neurosurg. Psychiatr. | pmid:14347622 |
| Murphy MG | Studies of the regulation of basal adenylate cyclase activity by membrane polyunsaturated fatty acids in cultured neuroblastoma. | 1986 | J. Neurochem. | pmid:3011993 |
| Baba A et al. | Modulation by unsaturated fatty acids of norepinephrine- and adenosine-induced formation of cyclic AMP in brain slices. | 1984 | J. Neurochem. | pmid:6315886 |
| Vaughan PF et al. | Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y. | 1993 | J. Neurochem. | pmid:8455030 |
| Youyou A et al. | Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain. | 1986 | J. Neurochem. | pmid:3940283 |
| Fressinaud C et al. | Fatty acid composition of endoneurium and perineurium from adult rat sciatic nerve. | 1986 | J. Neurochem. | pmid:3958717 |
| Quik M | Evidence for an involvement of membrane lipids in the control of neuronal nicotinic receptor function using bungarotoxin II-S1. | 1987 | J. Neurochem. | pmid:3106571 |
| Aoshima H | Potentiation and inhibition of ionotropic neurotransmitter receptors expressed in Xenopus oocyte by linoleic acid and its hydroperoxide. | 1996 | J. Neurochem. | pmid:8769897 |
| Khanna S et al. | Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. | 2006 | J. Neurochem. | pmid:16923160 |
| Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
| Moore SA et al. | Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. | 1990 | J. Neurochem. | pmid:2115069 |
| McKinney M | Blockade of receptor-mediated cyclic GMP formation by hydroxyeicosatetraenoic acid. | 1987 | J. Neurochem. | pmid:3037024 |
| Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
| Spector R | Fatty acid transport through the blood-brain barrier. | 1988 | J. Neurochem. | pmid:3335863 |
| Dyer JR and Greenwood CE | Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios. | 1991 | J. Neurochem. | pmid:1673995 |
| Duffield-Lillico AJ et al. | Can selenium prevent colorectal cancer? A signpost from epidemiology. | 2004 | J. Natl. Cancer Inst. | pmid:15547171 |
| Ingkaninan K et al. | Interference of linoleic acid fraction in some receptor binding assays. | 1999 | J. Nat. Prod. | pmid:10395519 |
| Piacente S et al. | Yucca schidigera bark: phenolic constituents and antioxidant activity. | 2004 | J. Nat. Prod. | pmid:15165156 |
| Xie P et al. | Metabonomic Study of Biochemical Changes in Human Hair of Heroin Abusers by Liquid Chromatography Coupled with Ion Trap-Time of Flight Mass Spectrometry. | 2016 | J. Mol. Neurosci. | pmid:26445826 |
| Spector AA | Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478370 |
| Harada H et al. | Enhanced suppression of myocardial slow action potentials during hypoxia by free fatty acids. | 1984 | J. Mol. Cell. Cardiol. | pmid:6716492 |
| Gillilan RE et al. | Structural basis for activation of fatty acid-binding protein 4. | 2007 | J. Mol. Biol. | pmid:17761196 |
| Mizushina Y et al. | Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. | 2000 | J. Mol. Biol. | pmid:11090281 |
| Napal L et al. | An intronic peroxisome proliferator-activated receptor-binding sequence mediates fatty acid induction of the human carnitine palmitoyltransferase 1A. | 2005 | J. Mol. Biol. | pmid:16271724 |
| Kapich AN et al. | A rapid method to quantify pro-oxidant activity in cultures of wood-decaying white-rot fungi. | 2005 | J. Microbiol. Methods | pmid:15722153 |
| Luo H et al. | The In vitro antioxidant properties of chinese highland lichens. | 2010 | J. Microbiol. Biotechnol. | pmid:21124057 |
| Nam IS and Garnsworthy PC | Factors influencing biohydrogenation and conjugated linoleic acid production by mixed rumen fungi. | 2007 | J. Microbiol. | pmid:17618224 |
| Lee YJ and Jenkins TC | Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. | 2011 | J. Microbiol. | pmid:21887646 |
| Farrington M et al. | Resistance to desiccation and skin fatty acids in outbreak strains of methicillin-resistant Staphylococcus aureus. | 1992 | J. Med. Microbiol. | pmid:1731060 |
| Tamura K et al. | Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants. | 2003 | J. Med. Chem. | pmid:12825946 |
| Labadaridis I et al. | Linoleic and arachidonic acid in perinatal asphyxia and prematurity. | 2007 | J. Matern. Fetal. Neonatal. Med. | pmid:17674280 |
| Marincola FC et al. | A metabolomic study of preterm human and formula milk by high resolution NMR and GC/MS analysis: preliminary results. | 2012 | J. Matern. Fetal. Neonatal. Med. | pmid:23025771 |
| Feldstein AE et al. | Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. | 2010 | J. Lipid Res. | pmid:20631297 |
| Wang T et al. | Formation of monohydroxy derivatives of arachidonic acid, linoleic acid, and oleic acid during oxidation of low density lipoprotein by copper ions and endothelial cells. | 1992 | J. Lipid Res. | pmid:1527476 |
| Bouwstra JA et al. | Role of ceramide 1 in the molecular organization of the stratum corneum lipids. | 1998 | J. Lipid Res. | pmid:9469597 |
| Chen TC et al. | Modulation of 1,25-dihydroxyvitamin D3 receptor by phospholipids and fatty acids. | 1984 | J. Lipid Res. | pmid:6099395 |
| Gao F et al. | Quantifying conversion of linoleic to arachidonic and other n-6 polyunsaturated fatty acids in unanesthetized rats. | 2010 | J. Lipid Res. | pmid:20622136 |
| Cho Y and Ziboh VA | Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. | 1994 | J. Lipid Res. | pmid:8169529 |
| Bretillon L et al. | Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men. | 2001 | J. Lipid Res. | pmid:11369808 |
| Banni S et al. | Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. | 2001 | J. Lipid Res. | pmid:11441132 |
| Ohtani H et al. | Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. | 1990 | J. Lipid Res. | pmid:2280182 |
| Heydeck D et al. | Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions. | 2001 | J. Lipid Res. | pmid:11441135 |
| van Greevenbroek MM et al. | Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. | 1995 | J. Lipid Res. | pmid:7706938 |
| Bayon Y et al. | Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. | 1995 | J. Lipid Res. | pmid:7706947 |
| Matsubara T et al. | TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. | 2012 | J. Lipid Res. | pmid:23034213 |
| Mensink RP et al. | Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. | 1992 | J. Lipid Res. | pmid:1431574 |
| Shen W et al. | Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. | 2013 | J. Lipid Res. | pmid:23401602 |
| Meilhac O et al. | Lipid peroxides induce expression of catalase in cultured vascular cells. | 2000 | J. Lipid Res. | pmid:10946007 |
| Niisuke K et al. | Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. | 2009 | J. Lipid Res. | pmid:19244216 |
| Vecchini A et al. | Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells. | 2004 | J. Lipid Res. | pmid:14563831 |
| Lin YH and Salem N | Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat. | 2007 | J. Lipid Res. | pmid:17876057 |
| Kilsdonk EP et al. | Effect of phospholipid fatty acid composition of endothelial cells on cholesterol efflux rates. | 1992 | J. Lipid Res. | pmid:1402404 |
| Rodriguez A et al. | Delta6- and delta5-desaturase activities in the human fetal liver: kinetic aspects. | 1998 | J. Lipid Res. | pmid:9741695 |
| Bazinet RP et al. | Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3. | 2003 | J. Lipid Res. | pmid:12576513 |
| Toborek M et al. | Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells. | 1996 | J. Lipid Res. | pmid:8820108 |
| Valianpour F et al. | Linoleic acid supplementation of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment. | 2003 | J. Lipid Res. | pmid:12562862 |
| Lee JY et al. | Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. | 2003 | J. Lipid Res. | pmid:12562875 |
| Viola G et al. | Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. | 1993 | J. Lipid Res. | pmid:8263409 |
| Su HM et al. | Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon. | 1999 | J. Lipid Res. | pmid:10393215 |
| Andersson C et al. | Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism. | 2008 | J. Lipid Res. | pmid:18441018 |
| Hellemans K et al. | PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. | 2003 | J. Lipid Res. | pmid:12576510 |
| Ando H et al. | Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis. | 1999 | J. Lipid Res. | pmid:10393216 |
| Staprans I et al. | Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. | 1996 | J. Lipid Res. | pmid:9026539 |
| Nakashima Y et al. | Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. | 1993 | J. Lipid Res. | pmid:8094090 |
| Marcelo CL and Dunham WR | Fatty acid metabolism studies of human epidermal cell cultures. | 1993 | J. Lipid Res. | pmid:8301228 |
| Demmelmair H et al. | Metabolism of U13C-labeled linoleic acid in lactating women. | 1998 | J. Lipid Res. | pmid:9684741 |
| Penumetcha M et al. | Enhanced solubilization and intestinal absorption of cholesterol by oxidized linoleic acid. | 2002 | J. Lipid Res. | pmid:12032164 |
| Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
| Goyens PL et al. | Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. | 2005 | J. Lipid Res. | pmid:15834128 |
| Hrboticky N et al. | Effect of linoleic acid-rich infant formula feeding on brain synaptosomal lipid accretion and enzyme thermotropic behavior in the piglet. | 1989 | J. Lipid Res. | pmid:2769072 |
| Bretillon L et al. | Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver. | 1998 | J. Lipid Res. | pmid:9799809 |
| Cunnane SC et al. | Substantial carbon recycling from linoleate into products of de novo lipogenesis occurs in rat liver even under conditions of extreme dietary linoleate deficiency. | 1998 | J. Lipid Res. | pmid:9799813 |
| Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
| Hussein N et al. | Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. | 2005 | J. Lipid Res. | pmid:15576848 |
| Korotkova M et al. | Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet. | 2002 | J. Lipid Res. | pmid:12364559 |
| Denning GM et al. | Effect of fatty acid modification on prostaglandin production by cultured 3T3 cells. | 1982 | J. Lipid Res. | pmid:6808070 |
| Kang LT and Vanderhoek JY | Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. | 1998 | J. Lipid Res. | pmid:9684751 |
| Zock PL and Katan MB | Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. | 1992 | J. Lipid Res. | pmid:1569387 |
| Mustad VA et al. | Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs. | 1996 | J. Lipid Res. | pmid:8978483 |
| Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
| Lima ES et al. | Cholesteryl nitrolinoleate, a nitrated lipid present in human blood plasma and lipoproteins. | 2003 | J. Lipid Res. | pmid:12837858 |
| Nguyen SD and Sok DE | Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. | 2004 | J. Lipid Res. | pmid:15375178 |
| Newman JW et al. | The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. | 2002 | J. Lipid Res. | pmid:12235189 |
| Takajo T et al. | Feedback activation of ferrous 5-lipoxygenase during leukotriene synthesis by coexisting linoleic acid. | 2007 | J. Lipid Res. | pmid:17337722 |
| Toborek M et al. | Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. | 1997 | J. Lipid Res. | pmid:9374137 |
| Tokumura A et al. | Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase. | 2000 | J. Lipid Res. | pmid:10828088 |
| Turgeon D et al. | Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. | 2003 | J. Lipid Res. | pmid:12639971 |
| HITCHCOCK C and JAMES AT | OXIDATION OF UNSATURATED FATTY ACIDS BY LEAF TISSUE. | 1964 | J. Lipid Res. | pmid:14221105 |
| Takabe W et al. | Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death. | 2016 | J. Lipid Res. | pmid:27647838 |
| Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
| Gorjão R et al. | Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. | 2007 | J. Lipid Res. | pmid:17592174 |
| Hachey DL et al. | Human lactation: maternal transfer of dietary triglycerides labeled with stable isotopes. | 1987 | J. Lipid Res. | pmid:3681142 |
| Mize CE et al. | Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. | 1995 | J. Lipid Res. | pmid:7665996 |