Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Otitis Externa D010032 8 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Aortic Diseases D001018 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Fu J et al. Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits. 2012 J. Food Sci. pmid:22747885
Wajid NA and Halpern BP Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids. 2012 Chem. Senses pmid:22459162
Ménard N et al. Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies. 2012 Pharm. Res. pmid:22451248
Bonacci G et al. Conjugated linoleic acid is a preferential substrate for fatty acid nitration. 2012 J. Biol. Chem. pmid:23144452
Gutla PV et al. Modulation of plant TPC channels by polyunsaturated fatty acids. 2012 J. Exp. Bot. pmid:23105130
Smith AN et al. Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators. 2012 J. Cell. Physiol. pmid:22105830
Shimomura K et al. Identification of the plant origin of propolis from Jeju Island, Korea, by observation of honeybee behavior and phytochemical analysis. 2012 Biosci. Biotechnol. Biochem. pmid:23132582
Cortie CH and Else PL Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications. 2012 Int J Mol Sci pmid:23203135
O'Donnell-Megaro AM et al. Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. 2012 J. Dairy Sci. pmid:23063161
Martorell P et al. Caenorhabditis elegans as a model to study the effectiveness and metabolic targets of dietary supplements used for obesity treatment: the specific case of a conjugated linoleic acid mixture (Tonalin). 2012 J. Agric. Food Chem. pmid:23072574
Hu ZP et al. Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model. 2012 J. Proteome Res. pmid:23078235
Heinze VM and Actis AB Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. 2012 Int J Food Sci Nutr pmid:21762028
Celia C et al. Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders. 2012 Biomed Microdevices pmid:21960035
Yumrutas O et al. Phenolic acid contents, essential oil compositions and antioxidant activities of two varieties of Salvia euphratica from Turkey. 2012 Nat. Prod. Res. pmid:21995274
Tyagi A et al. Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. 2012 Br. J. Nutr. pmid:22243775
Kurotani K et al. High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. 2012 Nutr Res pmid:23084639
Trevizan L et al. Maintenance of arachidonic acid and evidence of Δ5 desaturation in cats fed γ-linolenic and linoleic acid enriched diets. 2012 Lipids pmid:22249937
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Regensburger J et al. Fatty acids and vitamins generate singlet oxygen under UVB irradiation. 2012 Exp. Dermatol. pmid:22229443
Stachowska E et al. Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. 2012 Int J Food Sci Nutr pmid:21721848
Cheguru P et al. Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. 2012 Pflugers Arch. pmid:22218833
Mormile R et al. Linoleic acid and colorectal cancer cell growth suppression: is the deregulation of mitochondrial survivin the key factor? 2012 Int J Colorectal Dis pmid:22231621
Luévano-Martínez LA et al. A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. 2012 Biochem. J. pmid:22236206
Jorge AT et al. Schinus terebinthifolius Raddi extract and linoleic acid from Passiflora edulis synergistically decrease melanin synthesis in B16 cells and reconstituted epidermis. 2012 Int J Cosmet Sci pmid:22738140
Tao XM et al. Enhanced anticancer activity of gemcitabine coupling with conjugated linoleic acid against human breast cancer in vitro and in vivo. 2012 Eur J Pharm Biopharm pmid:22728546
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
Zengin G et al. Composition of essential oil and antioxidant capacity of Centaurea drabifolia Sm. subsp. detonsa (Bornm.) Wagenitz, endemic to Turkey. 2012 Nat. Prod. Res. pmid:21714737
Park EY et al. Effects of peptide fractions with different isoelectric points from wheat gluten hydrolysates on lipid oxidation in pork meat patties. 2012 J. Agric. Food Chem. pmid:22747172
Pestana JM et al. Effect of slaughter season and muscle type on the fatty acid composition, including conjugated linoleic acid isomers, and nutritional value of intramuscular fat in organic beef. 2012 J. Sci. Food Agric. pmid:22473659
Martínez Marín AL et al. Effects of feeding increasing dietary levels of high oleic or regular sunflower or linseed oil on fatty acid profile of goat milk. 2012 J. Dairy Sci. pmid:22459841
Maqbool A et al. Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22699835
da Silva Acosta D et al. Fullerene and omega-3 and omega-6 fatty acids on fish brain antioxidant status. 2012 Fish Physiol. Biochem. pmid:22451341
Li D et al. Antitumor efficacy of a novel CLA-PTX microemulsion against brain tumors: in vitro and in vivo findings. 2012 Int J Nanomedicine pmid:23269869
Zened A et al. In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. 2012 Animal pmid:22436225
Cerretani L et al. DSC evaluation of extra virgin olive oil stability under accelerated oxidative test: effect of fatty acid composition and phenol contents. 2012 J Oleo Sci pmid:22687775
Reynolds CM et al. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. 2012 Mol Nutr Food Res pmid:22700321
Ladeira MM et al. Lipids in the diet and the fatty acid profile in beef: a review and recent patents on the topic. 2012 Recent Pat Food Nutr Agric pmid:22702746
Kamitani S et al. Differences between group X and group V secretory phospholipase A(2) in lipolytic modification of lipoproteins. 2012 Cell. Mol. Biol. Lett. pmid:22706677
Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Yu T et al. Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. 2012 Pflugers Arch. pmid:22644615
de Sousa Ferreira Soares G et al. Spectroscopic and thermooxidative analysis of organic okra oil and seeds from Abelmoschus esculentus. 2012 ScientificWorldJournal pmid:22645459
Wiebe MG et al. Lipid production in batch and fed-batch cultures of Rhodosporidium toruloides from 5 and 6 carbon carbohydrates. 2012 BMC Biotechnol. pmid:22646156
Itakura H et al. The change in low-density lipoprotein cholesterol concentration is positively related to plasma docosahexaenoic acid but not eicosapentaenoic acid. 2012 J. Atheroscler. Thromb. pmid:22653220
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Chivandi E et al. Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. 2012 Jan-Feb In Vivo pmid:22210722
Alinezhad H et al. Biochemical activities of acetone extracts of Hyssopus angustifolius. 2012 Jul-Aug Acta Pol Pharm pmid:22876603
Moghaddam AH et al. Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. 2012 Jul-Aug Acta Pol Pharm pmid:22876611
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Kim SY et al. S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. 2013 Mol. Cells pmid:24046187
Nakashima R et al. Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. 2013 Toxicology pmid:23619606
Huang X et al. Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia. 2013 Clin. Cancer Res. pmid:23493348
McGowan MM et al. A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue. 2013 Breast Cancer Res. Treat. pmid:23417336
Mabalirajan U et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. 2013 Sci Rep pmid:23443229
Tokede OA et al. Plasma phospholipid trans fatty acids and risk of heart failure. 2013 Am. J. Clin. Nutr. pmid:23446892
Kirpich IA et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. 2013 Alcohol pmid:23453163
Emery JA et al. Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. 2013 PLoS ONE pmid:23460861
Bartók T et al. ESI-MS and MS/MS identification of the first ceramide analogues of fumonisin B₁ mycotoxin from a Fusarium verticillioides culture following RP-HPLC separation. 2013 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:23837460
Okada Y et al. Wing (Ib) cells in frog taste discs detect dietary unsaturated fatty acids. 2013 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:23872318
Van Ba H et al. Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. 2013 Meat Sci. pmid:23632107
Saín J et al. Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. 2013 Ann. Nutr. Metab. pmid:23594856
Nørskov NP et al. Multicompartmental nontargeted LC-MS metabolomics: explorative study on the metabolic responses of rye fiber versus refined wheat fiber intake in plasma and urine of hypercholesterolemic pigs. 2013 J. Proteome Res. pmid:23596967
Jung CH et al. The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. 2013 Metab. Clin. Exp. pmid:23639572
Carro M et al. Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. 2013 Theriogenology pmid:23273433
Li A et al. Thermally induced isomerization of linoleic acid in soybean oil. 2013 Chem. Phys. Lipids pmid:23261796
Mena J et al. Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. 2013 Vet. Immunol. Immunopathol. pmid:23267746
Li L et al. A novel galanin receptor 1a gene in zebrafish: tissue distribution, developmental expression roles in nutrition regulation. 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23268327
Soto-Guzman A et al. Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23332799
Poudyal H et al. Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23333092
Khan AA et al. Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. 2013 Nanomedicine (Lond) pmid:23311988
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Guo J et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. 2013 Animal pmid:23031491
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
D'Angeli S et al. Cold perception and gene expression differ in Olea europaea seed coat and embryo during drupe cold acclimation. 2013 New Phytol. pmid:23078289
Loizzo MR et al. Phenolics, aroma profile, and in vitro antioxidant activity of Italian dessert passito wine from Saracena (Italy). 2013 J. Food Sci. pmid:23574495
Brouwer IA et al. Trans fatty acids and cardiovascular health: research completed? 2013 Eur J Clin Nutr pmid:23531781
Mujtaba SF et al. Singlet oxygen mediated apoptosis by anthrone involving lysosomes and mitochondria at ambient UV exposure. 2013 J. Hazard. Mater. pmid:23542321
Wardhani DH et al. Inhibition kinetics of lipid oxidation of model foods by using antioxidant extract of fermented soybeans. 2013 Food Chem pmid:23561179
Garofalo JM et al. Mouse mammary gland is refractory to the effects of ethanol after natural lactation. 2013 Comp. Med. pmid:23561936
Høstmark AT and Haug A Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. 2013 Lipids Health Dis pmid:23521743
Franco-Pons N et al. Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. 2013 Ann. Surg. pmid:22964727
Al-Bishri WM Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. 2013 J Oleo Sci pmid:24005015
Luo C et al. Vegetable oil thermosets reinforced by tannin-lipid formulations. 2013 Acta Biomater pmid:22975626
Ramirez AM et al. A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. 2013 Lipids pmid:23893337
Daud AZ et al. The trans fatty acid content in human milk and its association with maternal diet among lactating mothers in Malaysia. 2013 Asia Pac J Clin Nutr pmid:23945414
Kummerow FA et al. Effects of trans fats on prostacyclin production. 2013 Scand. Cardiovasc. J. pmid:24228623
Satoh K Linoleic acid. A novel mechanism of endothelial cell dysfunction. 2013 Circ. J. pmid:24077059
Hashim A et al. Antioxidant and α -amylase inhibitory property of phyllanthus virgatus L.: an in vitro and molecular interaction study. 2013 Biomed Res Int pmid:23957001
Risé P et al. Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23910046
Xia Q et al. Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. 2013 Food Chem. Toxicol. pmid:23867545
Le Maux S et al. Complexes between linoleate and native or aggregated β-lactoglobulin: interaction parameters and in vitro cytotoxic effect. 2013 Food Chem pmid:23870962
Aladedunye F and Przybylski R Frying stability of high oleic sunflower oils as affected by composition of tocopherol isomers and linoleic acid content. 2013 Food Chem pmid:23870970
Chen HW et al. Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 Arch. Toxicol. pmid:23288142
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
Ngakegni-Limbili AC et al. Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. 2013 J. Sci. Food Agric. pmid:22692978
De Weirdt R et al. A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. 2013 Benef Microbes pmid:24311313
Li XP et al. Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. 2013 Lipids pmid:23341188
Okada Y et al. Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. 2013 Clin. Exp. Immunol. pmid:24028683
Peters BD et al. Polyunsaturated fatty acid concentration predicts myelin integrity in early-phase psychosis. 2013 Schizophr Bull pmid:22927668