Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Otitis Externa D010032 8 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Hypertension, Renal D006977 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Hyperpigmentation D017495 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
DeLange RJ and Glazer AN Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. 1990 Arch. Biochem. Biophys. pmid:2297222
Rustin P et al. Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mitochondria. 1983 Arch. Biochem. Biophys. pmid:6414377
Fuller MA et al. Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity. 2001 Arch. Biochem. Biophys. pmid:11361131
Tijet N et al. Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. 2001 Arch. Biochem. Biophys. pmid:11368353
Hamberg M and Hamberg G Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). 1990 Arch. Biochem. Biophys. pmid:2275553
Garcia Zevallos M and Farkas T Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. 1989 Arch. Biochem. Biophys. pmid:2786374
Guha SN et al. Free radical reductive degradation of vic-dibromoalkanes and reaction of bromine atoms with polyunsaturated fatty acids: possible involvement of Br(.) in the 1,2-dibromoethane-induced lipid peroxidation. 1993 Arch. Biochem. Biophys. pmid:8342946
Hamazaki S et al. Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. 1989 Arch. Biochem. Biophys. pmid:2500058
Palmieri-Thiers C et al. Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. 2011 Arch. Biochem. Biophys. pmid:21345329
Rossetto M et al. Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. 2002 Arch. Biochem. Biophys. pmid:12464277
Hörnsten L et al. Dexamethasone induces bisallylic hydroxylation of polyunsaturated fatty acids by rat liver microsomes. 1996 Arch. Biochem. Biophys. pmid:8806734
Sánchez J and Stumpf PK The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. 1984 Arch. Biochem. Biophys. pmid:6696430
Iwahashi H et al. Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. 1991 Arch. Biochem. Biophys. pmid:1846731
Wennman A et al. Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. 2014 Arch. Biochem. Biophys. pmid:24857825
KHAN NA Biological oxidation. I. The infrared studies on the lipoxidasecatalyzed oxidation of linoleic acid. 1953 Arch. Biochem. Biophys. pmid:13058378
Laidler P et al. Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? 2007 Arch. Biochem. Biophys. pmid:17466258
Berge RK et al. Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. 1987 Arch. Biochem. Biophys. pmid:2880562
Hamberg M Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. 1998 Arch. Biochem. Biophys. pmid:9448728
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Schwartz J et al. Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. 2009 Arch. Dis. Child. pmid:19193660
Ridsdill-Smith J et al. Induced responses in clover to an herbaceous mite. 2002 Arch. Insect Biochem. Physiol. pmid:12432518
Buckner JS and Hagen MM Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. 2003 Arch. Insect Biochem. Physiol. pmid:12761874
Laaksonen DE et al. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. 2005 Arch. Intern. Med. pmid:15668366
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Paraszkiewicz K et al. Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. 2010 Arch. Microbiol. pmid:20047047
Gustafsson MC et al. Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species. 2001 Arch. Microbiol. pmid:11734890
Rashid S et al. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. 2008 Arch. Ophthalmol. pmid:18268213
Seddon JM et al. Dietary fat and risk for advanced age-related macular degeneration. 2001 Arch. Ophthalmol. pmid:11483088
Huang CB et al. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. 2010 Arch. Oral Biol. pmid:20541177
Vukovic N et al. An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins. 2010 Arch. Pharm. Res. pmid:20191339
Gwak HS and Chun IK Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins. 2001 Arch. Pharm. Res. pmid:11794538
Canetti L et al. Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. 2014 Arch. Physiol. Biochem. pmid:24320056
Chen HW et al. Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 Arch. Toxicol. pmid:23288142
Bonanome A et al. Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. 1992 Arterioscler. Thromb. pmid:1558840
Reaven PD et al. Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. 1994 Arterioscler. Thromb. pmid:8148354
Ettinger WH et al. Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. 1994 Arterioscler. Thromb. pmid:8274481
Won JC et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965780
Belkner J et al. Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15681297
Nagelin MH et al. 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18635820
Tsimikas S et al. LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:9888874
Salomaa VV et al. Association of the fatty acid composition of serum phospholipids with hemostatic factors. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9157941
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Chancharme L et al. Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10073990
Augé N et al. Uptake of 13-hydroperoxylinoleic acid by cultured cells. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10195919
Gniwotta C et al. Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9409317
Rodríguez-Lee M et al. Fatty acids cause alterations of human arterial smooth muscle cell proteoglycans that increase the affinity for low-density lipoprotein. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16239593
Natarajan R and Nadler JL Lipid inflammatory mediators in diabetic vascular disease. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15166011
Loscalzo J et al. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. 1987 Sep-Oct Arteriosclerosis pmid:3675304
Hennig B et al. Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. 1984 Sep-Oct Arteriosclerosis pmid:6477300
Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee. 1982 Mar-Apr Arteriosclerosis pmid:7039581
Goodnight SH et al. Polyunsaturated fatty acids, hyperlipidemia, and thrombosis. 1982 Mar-Apr Arteriosclerosis pmid:7039582
Kaduce TL et al. Linoleic acid metabolism and prostaglandin production by cultured bovine pulmonary artery endothelial cells. 1982 Sep-Oct Arteriosclerosis pmid:6751307
Lucchi L et al. Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients. 2005 Artif Organs pmid:15854218
Canudas N et al. Photosensitizing properties of Actarit, an antirheumatic drug. 2008 Arzneimittelforschung pmid:18540480
Arutselvan N et al. Antioxidative activity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. 1999 Arzneimittelforschung pmid:10514898
French MA et al. Cholesterolaemic effect of palmitic acid in relation to other dietary fatty acids. 2002 Asia Pac J Clin Nutr pmid:12492626
Daud AZ et al. The trans fatty acid content in human milk and its association with maternal diet among lactating mothers in Malaysia. 2013 Asia Pac J Clin Nutr pmid:23945414
Liu Q et al. Dietary n-6:n-3 ratio and Vitamin E improve motility characteristics in association with membrane properties of boar spermatozoa. 2017 Mar-Apr Asian J. Androl. pmid:26763547
Turci F et al. Free-radical chemistry as a means to evaluate lunar dust health hazard in view of future missions to the moon. 2015 Astrobiology pmid:25946080
Rinker KD et al. Linoleic acid increases monocyte deformation and adhesion to endothelium. 2004 Atherosclerosis pmid:15530900
Tilvis RS et al. Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia. 1987 Atherosclerosis pmid:3619988
Sneddon AA et al. Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. 2003 Atherosclerosis pmid:14642406
Kromhout D et al. Long-term effects of a linoleic acid-enriched diet, changes in body weight and alcohol consumption on serum total and HDL-cholesterol. 1987 Atherosclerosis pmid:3632757
Berlin E et al. Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men. 1987 Atherosclerosis pmid:3632760
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Huang YS et al. Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). 1982 Atherosclerosis pmid:6279122
Garelnabi M et al. Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms. 2008 Atherosclerosis pmid:18243209
Solakivi T et al. Plasma apolipoprotein B in middle-aged Finnish men. Evidence for a regional gradient of apo B and lack of negative correlation between apo B and dietary linoleate in hyperapobetalipoproteinemia. 1988 Atherosclerosis pmid:3214459
Allman-Farinelli MA et al. Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. 1999 Atherosclerosis pmid:9920517
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
Ramasamy S et al. Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. 1996 Atherosclerosis pmid:8645361
Hornstra G and Kester AD Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model. 1997 Atherosclerosis pmid:9180241
de Waart FG et al. Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL. 1997 Atherosclerosis pmid:9298686
van Greevenbroek MM et al. Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. 1996 Atherosclerosis pmid:8678919
Wilson TA et al. Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: beyond linoleate. 1998 Atherosclerosis pmid:9733225
Jones PJ et al. High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. 2015 Atherosclerosis pmid:25528432
Porkkala-Sarataho E et al. Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. 1996 Atherosclerosis pmid:8800496
Benadé AJ et al. Plasma low density lipoprotein composition in relation to atherosclerosis in nutritionally defined Vervet monkeys. 1988 Atherosclerosis pmid:3145748
Waddington EI et al. Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. 2003 Atherosclerosis pmid:12618275
Weldon S et al. Conjugated linoleic acid and atherosclerosis: no effect on molecular markers of cholesterol homeostasis in THP-1 macrophages. 2004 Atherosclerosis pmid:15136056
Naqvi AZ et al. Dietary fatty acids and peripheral artery disease in adults. 2012 Atherosclerosis pmid:22552117
van Tol A et al. Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. 1995 Atherosclerosis pmid:7669083
Ohrvall M et al. Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. 1994 Atherosclerosis pmid:7980703
Lee KN et al. Conjugated linoleic acid and atherosclerosis in rabbits. 1994 Atherosclerosis pmid:7980704
Kurushima H et al. Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. 1995 Atherosclerosis pmid:7605390
Singer P et al. A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. 1990 Atherosclerosis pmid:2146966
Shiina T et al. Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. 1993 Atherosclerosis pmid:8141854
Liu SX et al. Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. 1998 Atherosclerosis pmid:9544730
Fuhrman B et al. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. 1994 Atherosclerosis pmid:7840815
Ramasamy S et al. Proteoglycans and endothelial barrier function: effect of linoleic acid exposure to porcine pulmonary artery endothelial cells. 1993 Atherosclerosis pmid:8292102
Lux CA et al. Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. 2009 Atherosclerosis pmid:19423111
Abraham RD et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. 1990 Atherosclerosis pmid:2112389
Hannah JS et al. High fat, high cholesterol diets alter low density lipoprotein size and binding affinity in monkeys. 1997 Atherosclerosis pmid:9247355
Fei J et al. ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. 2012 Atherosclerosis pmid:22464285
Litvinov D et al. Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. 2010 Atherosclerosis pmid:19880116
Artwohl M et al. Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. 2009 Atherosclerosis pmid:18597758
Singh SP et al. Absence of effect of prostaglandins on cholesteryl ester metabolism of 3T3 mouse fibroblasts grown in tissue culture. 1982 Atherosclerosis pmid:6952877
Koo SI and Ramlet JS Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high density lipoprotein cholesterol. 1984 Atherosclerosis pmid:6712766
Tavendale R et al. Adipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study. 1992 Atherosclerosis pmid:1632870
Lecerf J et al. Variations in the fatty acid composition of lipid classes from lipoproteins in elderly women. 1993 Atherosclerosis pmid:8457263