Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Aortic Diseases D001018 11 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Zamora-Rojas E et al. Prediction of fatty acids content in pig adipose tissue by near infrared spectroscopy: at-line versus in-situ analysis. 2013 Meat Sci. pmid:23793086
Dal Bosco A et al. Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. 2014 Meat Sci. pmid:24036258
Toomik P et al. The effect of tenderizing acids on linoleic acid oxidation during marination of pork. 2012 Meat Sci. pmid:22762994
Tume RK et al. Enriching M. sternomandibularis with alpha-tocopherol by dietary means does not protect against the lipid oxidation caused by high-pressure processing. 2010 Meat Sci. pmid:20374755
Berthelot V et al. Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. 2010 Meat Sci. pmid:20374762
Song S et al. Identification of pork flavour precursors from enzyme-treated lard using Maillard model system assessed by GC-MS and partial least squares regression. 2017 Meat Sci. pmid:27792915
Cannata S et al. Effect of visual marbling on sensory properties and quality traits of pork loin. 2010 Meat Sci. pmid:20416803
Jokela H et al. Fatty acid and cholesterol composition of the uterine artery intima in relation to menopausal status, age, and serum cholesterol. 2004 Maturitas pmid:14757270
Yang Z and Huffman SL Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. 2013 Matern Child Nutr pmid:23167585
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Lauritzen L and Carlson SE Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. 2011 Matern Child Nutr pmid:21366866
Brenna JT Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. 2011 Matern Child Nutr pmid:21366867
Briend A et al. Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. 2011 Matern Child Nutr pmid:21366873
Parra-Cabrera S et al. Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. 2011 Matern Child Nutr pmid:21410881
Marinho GS et al. Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. 2015 Mar Drugs pmid:26184241
Yoshiki Y et al. Chemiluminescence and reactive oxygen scavenging activities of the hydrogen peroxide/gallic acid/lactoperoxidase system. 2000 May-Jun Luminescence pmid:10862147
Rondanelli M et al. Effects of two-months balanced diet in metabolically healthy obesity: lipid correlations with gender and BMI-related differences. 2015 Lipids Health Dis pmid:26511930
Min JS et al. Monitoring the formation of cholesterol oxidation products in model systems using response surface methodology. 2015 Lipids Health Dis pmid:26201850
Song Y et al. Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members. 2013 Lipids Health Dis pmid:23879935
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Cedernaes J et al. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. 2013 Lipids Health Dis pmid:23298201
Tang KS Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. 2014 Lipids Health Dis pmid:25522984
Maruyama H et al. Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. 2014 Lipids Health Dis pmid:24885871
Dai J et al. Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. 2013 Lipids Health Dis pmid:23663688
Nasrollahzadeh J et al. The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. 2008 Lipids Health Dis pmid:19014610
Høstmark AT and Haug A Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. 2013 Lipids Health Dis pmid:23521743
Shen J et al. Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. 2012 Lipids Health Dis pmid:22781401
Bjørkkjaer T et al. Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease. 2006 Lipids Health Dis pmid:16549021
Muralikumar S et al. Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. 2017 Lipids Health Dis pmid:28109294
Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Karupaiah T et al. Comparing effects of soybean oil- and palm olein-based mayonnaise consumption on the plasma lipid and lipoprotein profiles in human subjects: a double-blind randomized controlled trial with cross-over design. 2016 Lipids Health Dis pmid:27535127
Lu X et al. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. 2010 Lipids Health Dis pmid:20868498
Khiaosa-ard R et al. Methods of emulsifying linoleic acid in biohydrogenation studies in vitro may bias the resulting fatty acid profiles. 2010 Lipids pmid:20582723
Pérez-Matute P et al. Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin. 2007 Lipids pmid:17647039
Petzinger C et al. Lipid metabolic dose response to dietary alpha-linolenic acid in monk parrot (Myiopsitta monachus). 2014 Lipids pmid:24293226
Wien M et al. Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. 2010 Lipids pmid:20496049
Stamey Lanier J et al. Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. 2013 Lipids pmid:23504269
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Bannenberg G et al. Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. 2009 Lipids pmid:18949503
Morita M and Tokita M Hydroxy radical, hexanal, and decadienal generation by autocatalysts in autoxidation of linoleate alone and with eleostearate. 2008 Lipids pmid:18493810
Boeglin WE et al. Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases. 2008 Lipids pmid:18795358
Koussoroplis AM et al. From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. 2008 Lipids pmid:18335265
Jouany JP et al. Dynamic features of the rumen metabolism of linoleic acid, linolenic acid and linseed oil measured in vitro. 2007 Lipids pmid:17406930
Xue C et al. Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. 2012 Lipids pmid:22120618
Jernerén F et al. Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. 2012 Lipids pmid:22048860
Spartano NL et al. Linoleic acid suppresses cholesterol efflux and ATP-binding cassette transporters in murine bone marrow-derived macrophages. 2014 Lipids pmid:24595513
Bin Q et al. The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. 2013 Lipids pmid:23065354
Trevizan L et al. Maintenance of arachidonic acid and evidence of Δ5 desaturation in cats fed γ-linolenic and linoleic acid enriched diets. 2012 Lipids pmid:22249937
Bowden JA et al. Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. 2011 Lipids pmid:21904795
Rodrigues HG et al. Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats. 2010 Lipids pmid:20730605
Ramirez AM et al. A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. 2013 Lipids pmid:23893337
Alvheim AR et al. Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. 2014 Lipids pmid:24081493
Rosenblat M et al. Nitro-Oleic Acid Reduces J774A.1 Macrophage Oxidative Status and Triglyceride Mass: Involvement of Paraoxonase2 and Triglyceride Metabolizing Enzymes. 2016 Lipids pmid:27344666
Yang Y et al. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. 2014 Lipids pmid:24777581
Ghezzi S et al. Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells. 2007 Lipids pmid:17551762
Li XP et al. Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. 2013 Lipids pmid:23341188
Hamberg M Stereochemistry of hydrogen removal during oxygenation of linoleic acid by singlet oxygen and synthesis of 11(S)-deuterium-labeled linoleic acid. 2011 Lipids pmid:21161604
Saija A et al. In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G. 2001 Life Sci. pmid:11388688
Sauer LA et al. Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction. 2001 Life Sci. pmid:11432449
Nomura T et al. A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway. 2001 Life Sci. pmid:11432454
Takeda M et al. Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test. 2001 Life Sci. pmid:11487096
Yao HT et al. The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. 2006 Life Sci. pmid:16978661
Sokmen M et al. In vitro antioxidant activity of polyphenol extracts with antiviral properties from Geranium sanguineum L. 2005 Life Sci. pmid:15820508
Montoudis A et al. Influence of a maternal cholesterol-enriched diet on [1-14C]-linoleic acid and L-[4, 5-3H]-leucine entry in plasma of rabbit offspring. 2004 Life Sci. pmid:14741733
Miyazawa D et al. Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. 2003 Life Sci. pmid:12899931
Tuei VC et al. Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. 2011 Life Sci. pmid:21396379
Cury-Boaventura MF et al. Comparative toxicity of oleic and linoleic acid on human lymphocytes. 2006 Life Sci. pmid:16236329
Gülçin I Antioxidant and antiradical activities of L-carnitine. 2006 Life Sci. pmid:16253281
Alba-Loureiro TC et al. Role of insulin on PGE2 generation during LPS-induced lung inflammation in rats. 2006 Life Sci. pmid:16143347
Kummerow FA et al. 27-Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients. 2006 Life Sci. pmid:16154158
Hudson JA et al. Hydration of oleic acid by a Selenomonas strain from the ovine rumen. 1996 Lett. Appl. Microbiol. pmid:8862016
Howard FA and Henderson C Hydrogenation of polyunsaturated fatty acids by human colonic bacteria. 1999 Lett. Appl. Microbiol. pmid:10530040
Bojar RA et al. The effect of lipids on the adherence of axillary aerobic coryneform bacteria. 2004 Lett. Appl. Microbiol. pmid:15130141
Van Nieuwenhove CP et al. Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk. 2007 Lett. Appl. Microbiol. pmid:17451511
Ruths M et al. Friction of fatty acids in nanometer-sized contacts of different adhesive strength. 2008 Langmuir pmid:18085802
Gage SH et al. Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. 2013 Langmuir pmid:23234434
Negrini R et al. Influence of electrostatic interactions on the release of charged molecules from lipid cubic phases. 2014 Langmuir pmid:24673189
Negrini R and Mezzenga R pH-responsive lyotropic liquid crystals for controlled drug delivery. 2011 Langmuir pmid:21452814
Wood MH et al. Comparative Adsorption of Saturated and Unsaturated Fatty Acids at the Iron Oxide/Oil Interface. 2016 Langmuir pmid:26707597
Roberts TL et al. trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. 1995 Lancet pmid:7837861
Lipids and multiple sclerosis. 1990 Lancet pmid:1973215
Groves BA Exit linoleic acid too? 1996 Lancet pmid:8531562
FULD H and HORWICH L Xanthomatous biliary cirrhosis treated with ethyl linoleate. 1959 Lancet pmid:13655619
Smith MT and Thompson S Free radicals and alcoholics. 1985 Lancet pmid:2864501
GUNNING BE et al. EFFECTS OF DIFFERENT DIETARY FATS ON PLASMA-LIPID LEVELS. 1964 Lancet pmid:14172332
Erskine KJ et al. An altered ratio of 18:2 (9,11) to 18:2 (9,12) linoleic acid in plasma phospholipids as a possible predictor of pre-eclampsia. 1985 Lancet pmid:2857904
Fink R et al. Increased free-radical activity in alcoholics. 1985 Lancet pmid:2862465
Wood DA et al. Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. 1984 Lancet pmid:6146032
Pruzanski W et al. Mitogenic effect of lipoproteins on human vascular smooth muscle cells: the impact of hydrolysis by gr II A phospholipase A(2). 2001 Lab. Invest. pmid:11351047
Kurinami S et al. Effects of polyunsaturated fatty acids and/or lecithin on the plasma concentrations of very low density lipoprotein-tryglyceride (VLDL) and ketone bodies in humans. 1988 Kurume Med J pmid:3193745
Ogborn MR et al. Dietary conjugated linoleic acid reduces PGE2 release and interstitial injury in rat polycystic kidney disease. 2003 Kidney Int. pmid:12969139
Lucchi L et al. Changes in conjugated linoleic acid and its metabolites in patients with chronic renal failure. 2000 Kidney Int. pmid:11012903
Heifets M et al. Effect of dietary lipids on renal function in rats with subtotal nephrectomy. 1987 Kidney Int. pmid:3669493
SUEYOSHI Y and NAGAO Y Studies on the linoleic acid contents in the phospholipids of the sarcoma. 1962 Keio J Med pmid:13918168
SUEYOSHI Y and NAGAO Y The influence of linoleic acid upon the growth of transplanted sarcoma. 1962 Keio J Med pmid:13979090
Saha SK et al. Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. 1997 Jpn. J. Physiol. pmid:9504135
IMAI Y and ARAMAKI Y LINOLEIC ACID COMPONENT IN THE HYPERLIPIDEMIA INDUCED BY TRITON. 1964 Jpn. J. Pharmacol. pmid:14215540
Siguel E Essential fatty acid status in patients. 1997 Jul-Aug JPEN J Parenter Enteral Nutr pmid:9252955
Lokesh B et al. Effect of different dietary triglycerides on liver fatty acids and prostaglandin synthesis by mouse peritoneal cells. 1992 Jul-Aug JPEN J Parenter Enteral Nutr pmid:1640628
Cabré E et al. Plasma polyunsaturated fatty acids in liver cirrhosis with or without chronic hepatic encephalopathy: a preliminary study. 1992 Jul-Aug JPEN J Parenter Enteral Nutr pmid:1386392